Version 2.80

Part Description

LP412092-1   Acetaminophen-cysteine adduct
Acetaminophen-cysteine adduct (APAP-CYS) levels are measured in serum or plasma for the determination of liver injury due to acetaminophen-induced hepatotoxicity. PMID: 27641661 The reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI), is detoxified by glutathione at therapeutic doses. However, when glutathione is depleted, the metabolite covalently binds to cysteine groups on proteins and forms a acetaminophen-cysteine conjugate (3-(cystein-S-yl)-acetaminophen, APAP-CYS), which is thought to lead to hepatotoxicity. PMID: 11901099 Source: LOINC , An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Fully-Specified Name

Component
Acetaminophen-cysteine adduct
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
LC/MS/MS

Additional Names

Long Common Name
Acetaminophen-cysteine adduct [Moles/volume] in Serum or Plasma by LC/MS/MS
Short Name
APAP-Cysteine SerPl LC/MS/MS-sCnc
Display Name
Acetaminophen-cysteine adduct LC/MS/MS [Moles/Vol]
Consumer Name Alpha Get Info
Acetaminophen-cysteine adduct, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51381-8 Acetaminophen-cysteine adduct|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Προϊόν προσθήκης ακεταμινοφαίνης-κυστεΐνης:SCnc:Pt:Ορός/Πλάσμα:Qn:LC/MS/MS
Synonyms: SCnc Ακεταμινοφαίνη Κυστεΐνη Προϊόν προσθήκης ακεταμινοφαίνης-κυστεΐνης
es-ES Spanish (Spain) Aducto de acetaminofeno-cisteína:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:LC/MS/MS
Synonyms: Cuantitativo
fr-FR French (France) Acétaminophène-cystéine adduit:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:LC/MS/MS
it-IT Italian (Italy) Acetaminofene-cisteina, addotto:SCnc:Pt:Siero/Plasma:Qn:LC/MS/MS
Synonyms: Addotto di acetaminofene-cisteina Concentrazione di Sostanza Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 对乙酰氨基酚-半胱氨酸加合物:物质的量浓度:时间点:血清/血浆:定量型:LC/MS/MS
Synonyms: Cys;巯基丙氨酸 Tandem Mass Spectrometry;MS/MS;串联质谱分析;串联质谱法;mass spectrometer;MS;质谱法;质谱分析;liquid chromatography;LC;液相色谱分析;Liquid Chromatography-Tandem Mass Spectrometry;liquid chromatography-MS/MS;LC-MS/MS;液相色谱分析-串联质谱分析法;液相色谱-串联质谱检测方法;液相色谱质谱联用技术;串联质谱快速分析 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 对乙酰氨基酚（扑热息痛、退热净、醋氨酚、醋胺酚）-半胱氨酸（Cys、巯基丙氨酸）加合物（加成物） 扑热息痛;退热净;退热净( 一种替代阿司匹林的解热镇痛药);醋氨酚;醋氨酚晶体化合物;醋胺酚 时刻;随机;随意;瞬间 毒品 毒品类 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
nmol/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=99409-5