LOINC
Version 2.72

100026-4MET gene mutations found [Identifier] in Blood or Tissue by Molecular genetics method NominalActive

Part Description

LP265710-6   MET gene
The MET gene (MET proto-oncogene, receptor tyrosine kinase) [HGNC Gene ID:7029] is located on chromosome 7q31.2. This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] [NCBI Gene ID:4233] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
MET gene targeted mutation analysis
Property
Prid
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Short Name
MET gene Mut Anl Bld/T
Display Name
MET gene targeted mutation analysis Molgen Nom (Bld/Tiss)
Consumer Name Alpha
MET gene variant analysis, Blood or tissue specimen

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72
Order vs. Observation
Both

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=100026-4