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Term Description

Identifying monoclonal gammopathy isotypes using 24H urine specimens.

Part Descriptions

LP186074-3   MS.MALDI-TOF
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373 Source: Regenstrief LOINC, PMID: 23824373

LP269335-8   Protein.monoclonal isotype
A monoclonal band (M-spike, monoclonal protein isotype) is often found in patients with monoclonal gammopathies. Following protein electrophoresis, immunofixation is used to identify the immunoglobulin heavy chain and/or light chain. Monoclonal peaks greater than 3 g/dL and IgG or IgA are seen in patients with Multiple Myeloma (MM). A monoclonal peak greater than 3 g/dL and IgM is seen in patients with macroglobulinemia. An alternate methodology for identifying the monoclonal protein isotype is MALDI-TOF, in which known information regarding the unique mass of each isotype is used to determine and quantify the isotype present in the patient sample based on the mass spectra generated from the sample. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Protein.monoclonal isotype:Prid:24H:Urine:Nom:MS.MALDI-TOF
Long Common Name
Protein.monoclonal isotype [Identifier] in 24 hour Urine by MS.MALDI-TOF
Short Name
M Protein isotype 24h Ur MS.MALDI-TOF
Display Name
Protein.monoclonal isotype MS.MALDI-TOF Nom (24H U)
Consumer Name Alpha Get Info
Protein.monoclonal isotype, Urine

Part Model Get Info

  • Component
    Protein.monoclonal isotype
    LP269335-8
    • Analyte
      Protein.monoclonal isotype
      LP269335-8
      • Component Numerator
        Protein.monoclonal isotype
        LP269335-8
        • Component Numerator Core
          Protein.monoclonal isotype
          LP269335-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    24H
    LP6924-7
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    MS.MALDI-TOF
    LP186074-3

Example Answer List: LL5149-1

Source: NCBI PubMed
AnswerCodeScoreAnswer ID
No monoclonal protein detectedLA29537-0
Monoclonal IgA lambdaLA29536-2
Monoclonal IgG kappaLA29538-8
Monoclonal IgM kappaLA29539-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75 (ADD)
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
101665-8Protein electrophoresis and M protein isotype panel - 24 hour Urine

Member of these Groups Get Info

LOINC GroupGroup Name
LG51451-9Protein.monoclonal isotype|Prid|Urine

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Protein.monoklonální izotyp:Přítomnost nebo identita:24 hodin:Moč:Nominální:Hmotnostní spektrometrie.MALDI-TOF
el-GRGreek (Greece)Πρωτεΐνη.μονοκλωνικός ισότυπος:Prid:24H:Ούρα:Nom:MS.MALDI-TOF
Synonyms: 24H CHEM MS.MALDI-TOF Nom Prid Ούρα Πρωτεΐνη Πρωτεΐνη.μονοκλωνική Πρωτεΐνη.μονοκλωνικός ισότυπος
es-ESSpanish (Spain)Isotipo de proteína monoclonal:Presencia o identidad:24 horas:Orina:Nom:MS.MALDI-TOF
fr-FRFrench (France)Protéine monoclonale isotype:Identification:24H:Urine:Résultat nominal:Spectrométrie MALDI-TOF
it-ITItalian (Italy)Proteina.isotipo monoclonale:Prid:24h:Urine:Nom:MS.MALDI-TOF
Synonyms: 24 Ore Chimica Presenza o Identità
nl-NLDutch (Netherlands)eiwit.monoklonaal isotype:identificator:24 uur:urine:nominaal:MALDI-TOF
Synonyms: 24U massaspectometrie; Malditof
pl-PLPolish (Poland)Izotyp białka monoklonalnego:obecność lub identyfikacja:24h:mocz:skala nominalna:spektrometria mas.MALDI-TOF
Synonyms: 24 godziny wynik kategorialny
zh-CNChinese (China)蛋白质.单克隆同种型:存在与否或特征标识:24小时:尿液:名义型:MS.MALDI-TOF
Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 M 区带;M 峰;M 带;M 蛋白;副蛋白;单克隆区带;单克隆型蛋白质;单克隆型蛋白质区带;单克隆峰;单克隆性蛋白质;单克隆性蛋白质区带;单克隆蛋白质区带;异常蛋白;病变蛋白;蛋白质.单克隆 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 基质辅助激光解吸/电离飞行时间质谱;基质辅助激光解吸电离飞行时间质谱;基质辅助激光解吸飞行时间质谱;基质辅助激光解析电离飞行时间质谱;Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry;MALDI-TOF-MS;Matrix-assisted laser desorption ionization-time of flight 存在;存在与否;特征标识;身份;身份标识 尿;小便;下泉 蛋白质（蛋白）.单克隆同种型;单克隆同种型蛋白质（蛋白）

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101666-6