16128-1 Hepatitis C virus Ab [Presence] in Serum

Part Descriptions

LP14400-3   Hepatitis C virus
Hepatitis C virus (HCV) is a small (50 nm in size), enveloped, single-stranded, positive sense RNA virus in the genus hepacivirus, which is in the Flaviviridae family. More than 170 million people worldwide are affected by hepatitis C, and the majority of patients with acute hepatitis C develop chronic HCV infection, which can result in liver cirrhosis, hepatic failure or hepatocellular carcinoma. The HCV core protein is a highly basic, RNA-binding protein that forms the viral capsid. The E1 and E2 envelope glycoproteins are necessary for viral entry and fusion. Non-structural proteins include NS2, NS3, NS4A and 4B, and NS5A and 5B. The NS2-NS3 complex functions as a protease, and NS3 also has a helicase/NTPase domain. NS4A is a cofactor of NS3 protease activity. NS3-NS4A protease is one target of anti-HCV drugs. NS4B is a membrane anchor for the replication complex, and NS5A plays a role in regulating viral replication. NS5B is an RNA-dependent RNA polymerase. [NCBI Books: NBK1630] Source: Regenstrief LOINC, NCBI Books: NBK1630

Fully-Specified Name

Component

Hepatitis C virus Ab

Property

PrThr

Time

Pt

System

Ser

Scale

Ord

Method

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 1.0l

Last Updated

Version 2.73 (MIN)

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

259

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• HCV
• HCVAB
• Hep
• Hep C
• Hepatis
• Hepatit
• Hepatology
• ID
• Infectious Disease
• InfectiousDisease
• Liver
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Serum
• SR
• UniversalLabOrders

56888-1 HIV 1+2 Ab+HIV1 p24 Ag [Presence] in Serum or Plasma by Immunoassay

Part Descriptions

LP96332-9   HIV 1+2 Ab+HIV1 p24
This test detects HIV-1 core protein, p24, antigen and/or HIV-1 groups M and O Ab and/or HIV-2 Ab in serum or plasma as one combined positive or negative result based on a signal to cut-off (S/CO) value of 1.00. The p24 antigen can be detected in HIV infected persons before seroconversion, thus reducing the window of non-detectability in early infection. Viral transmembrane proteins (TMP) are among the first to appear at seroconversion and remain strong throughout the asymptomatic and symptomatic stages of HIV infection. They are the principle target of HIV antibody tests. Source: Regenstrief Help

Reference Information

Fully-Specified Name

Component

HIV 1+2 Ab+HIV1 p24 Ag

Property

PrThr

Time

Pt

System

Ser/Plas

Scale

Ord

Method

IA

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.29

Last Updated

Version 2.73 (MIN)

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

224

Member of these Panels

Language Variants Get Info

Related Names

• AIDS
• Antigen
• Antigens
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• HIV 1 & 2
• HIV 1 and 2 Ab
• HIV 1+2 Ab+HIV1p24
• HIV type 1
• HIV type I
• HIV1
• HIV1+2
• HIV1+2 Ab+HIV1p24Ag
• Human immunodeficiency virus
• i
• IAA
• ID
• II
• Infectious Disease
• InfectiousDisease
• MEIA
• Microbiology
• Ordinal
• Pl
• Plasma
• Plsm
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• SUDS

24110-9 Treponema pallidum Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP14042-3   Treponema pallidum
Treponema pallidum is a spirochaete bacterium. Pathogenic treponemes are classified based upon their clinical manifestations in humans: venereal syphilis, yaws, endemic syphilis and pinta. Nonpathogenic treponemes are often part of the normal flora of the genital tract, oral cavity or intestinal tract. Treponemal infections exhibit diverse clinical manifestations which are characterized by distinct clinical stages. Multiplication of the bacterium at the entry point causes the primary stage. Dissemination of treponemes to other tissues produces the second stage. After a latency period (up to 20 to 30 years), the tertiary stage develops. T. palladum subsp pallidum (venereal syphilis) is the most destructive subspecies and produces lesions in many bodily tissues including the central nervous system. Congenital syphilis may result in birth defects or fetal death. Venereal syphilis is sexually acquired except for congenital syphilis, which is transmitted to the fetus during the later stages of pregnancy. The other treponemes are acquired by close nonvenereal contact. Control of both venereal and nonvenereal disease is based upon surveillance and antibiotic treatment of contacts. [NCBI Books:NBK7716] Source: Regenstrief LOINC

Fully-Specified Name

Component

Treponema pallidum Ab

Property

PrThr

Time

Pt

System

Ser

Scale

Ord

Method

IA

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 1.0o

Last Updated

Version 2.82 (MIN)

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

2036

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• IAA
• ID
• Infectious Disease
• InfectiousDisease
• MEIA
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Serum
• SR
• SUDS
• Syphilis
• T palldm
• T pallidum
• Treponemal
• UniversalLabOrders