Version 2.78

3969-3 Phenytoin Free [Mass/volume] in Serum or Plasma

Part Descriptions

LP14731-1   Phenytoin.free
Phenytoin-free levels detect the level of non-protein-bound phenytoin in the blood. It is used to measure therapeutic and toxic levels of the drug. Source: Regenstrief Institute

LP207910-3   free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity. Source: Regenstrief LOINC

Observation Required in Panel

Required

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component
Phenytoin.free
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Phenytoin Free SerPl-mCnc
Display Name
Phenytoin Free [Mass/Vol]
Consumer Name Alpha Get Info
Free phenytoin, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Change Reason
Changed Order_Obs from 'Observation Only' to fit the current order use cases.
Order vs. Observation
Both
Common Test Rank Get Info
1466

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets
34540-5 Phenytoin free and total panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG47569-5 Phenytoin.free|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Phenytoin.frei:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
es-ES Spanish (Spain) Fenitoína libre:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-AR Spanish (Argentina) fenitoína.libre:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MX Spanish (Mexico) Phenytoin.libre:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Fenütoiin.vaba:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Phénytoïne.libre:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-BE French (Belgium) Phénytoïne.libre:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Diphénylhydantoïne libre:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Fenitoina.libera:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Fenitoina Libera Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 유리페니토인:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) fenytoïne.vrij:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Fenitoína.livre:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Diphenylhydantoin; Dilantin; DPH; Dilj; DI-HYDAN; Epanutin; Fenantoin; Lehydan; Phenhydan; Sinergina; Zentropil; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; FR; Non-protein bound; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Фенитоин.свободный:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Fenitoin.serb:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 苯妥英.游离型:质量浓度:时间点:血清/血浆:定量型:
Synonyms: C15H12N2O2;二苯乙内酰脲;苯妥营;二苯基乙内酰脲;二苯尿囊素 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 游离 游离型苯妥英;游离苯妥英;苯妥英.游离;苯妥英（二苯乙内酰脲、二苯基乙内酰脲、二苯尿囊素、苯妥营）.游离型 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
ug/mL Example UCUM Units
mcg/mL REGENSTRIEF

3968-5 Phenytoin [Mass/volume] in Serum or Plasma

Part Descriptions

LP14732-9   Phenytoin
An anticonvulsant that is used to treat a wide variety of seizure disorders. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its side effects and interactions with other drugs. [MeSH 2014: Phenytoin] Source: National Library of Medicine, MeSH 2006, MeSH: Phenytoin

Observation Required in Panel

Required

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component
Phenytoin
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Phenytoin SerPl-mCnc
Display Name
Phenytoin [Mass/Vol]
Consumer Name Alpha Get Info
Phenytoin, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
874

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets
104596-2 Phenytoin and Phenobarbital panel - Serum
34540-5 Phenytoin free and total panel - Serum or Plasma
55427-9 Seizure disorder tracking panel

Member of these Groups Get Info

LOINC Group Group Name
LG49335-9 Phenytoin|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Phenytoin
de-DE German (Germany) Phenytoin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
el-GR Greek (Greece) Φαινυντοΐνη:Συγκέντρωση μάζας:Χρονική στιγμή:Ορός/Πλάσμα:Ποσοτική:
es-MX Spanish (Mexico) Fenitoína:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-AR Spanish (Argentina) fenitoína:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Fenitoína:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Fenütoiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Phénytoïne:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-BE French (Belgium) Phénytoïne:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Diphénylhydantoïne:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Fenitoina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 페니토인:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) fenytoïne:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Fenitoína:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Diphenylhydantoin; Dilantin; DPH; Dilj; DI-HYDAN; Epanutin; Fenantoin; Lehydan; Phenhydan; Sinergina; Zentropil; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Фенитоин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Fenitoin:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 苯妥英:质量浓度:时间点:血清/血浆:定量型:
Synonyms: C15H12N2O2;二苯乙内酰脲;苯妥营;二苯基乙内酰脲;二苯尿囊素 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units
mcg/mL REGENSTRIEF