57702-3 Infectious diseases newborn screen interpretation

Observation Required in Panel

Required

Fully-Specified Name

Component

Infectious diseases

Property

Imp

Time

Pt

System

Bld.dot

Scale

Nom

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.29

Last Updated

Version 2.56 (MIN)

Change Reason

Changed answer list from "Normative" to "Preferred" to fit the current LOINC model.

Order vs. Observation

Observation

Preferred Answer List LL833-5

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Language Variants Get Info

Related Names

• Blood
• Chemistry
• DBS
• Dried blood spot
• Filter paper
• FP
• Impression
• Impression/interpretation of study
• Impressions
• Interp
• Interpretation
• Nominal
• Point in time
• Random
• WB
• Whole blood

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.

57701-5 Infectious diseases newborn screening comment-discussion

Observation Required in Panel

Conditional

Fully-Specified Name

Component

Infectious diseases newborn screening comment-discussion

Property

Txt

Time

Pt

System

Bld.dot

Scale

Nar

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.29

Last Updated

Version 2.42 (MIN)

Order vs. Observation

Observation

Member of these Panels

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Related Names

• Asympt
• Asymptomatic
• Blood
• Chemistry
• cmmt
• cmnt
• Com
• Comm
• Comments
• Commt
• DBS
• Dried blood spot
• Filter paper
• FP
• ID NBS comment
• Narrative
• NBS comment
• New born
• Point in time
• Random
• Remarks
• Report
• Scn
• Text
• WB
• Whole blood

54086-4 HIV 1+2 IgG Ab [Presence] in DBS

Part Descriptions

LP16715-2   HIV 1+2
Two types of human immunodeficiency viruses (HIV) have been characterized: HIV-1 and HIV-2. HIV-1 was initially discovered in the early 1980s and thought to be the sole causative agent of HIV infections and ultimately AIDS. In 1986, HIV-2 was isolated and also found to cause AIDs. HIV-1 is more virulent and the predominant cause of the HIV infections worldwide. HIV-2 is poorly transmitted and is primarily concentrated in West Africa.

Presently (2012), HIV-1 strains are divided into four groups, including group M (major) with subtypes A through K, group O (outlier), group N (non-M or O), and group P. HIV-2 is divided into subtypes A through E. Occasionally, two viruses of different subtypes can "cross react" and blend their genetic material to create a new hybrid HIV virus. However, many of these new strains do not survive for long. Studies have also shown that the core proteins of HIV-1 and HIV-2 display frequent cross-reactivity whereas the envelope proteins are more type-specific. Source: Regenstrief LOINC

Observation Required in Panel

Conditional

Fully-Specified Name

Component

HIV 1+2 Ab.IgG

Property

PrThr

Time

Pt

System

Bld.dot

Scale

Ord

Method

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.26

Last Updated

Version 2.61 (MIN)

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

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Related Names

• ABS
• Aby
• AIDS
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• Blood
• DBS
• Dried blood spot
• Filter paper
• FP
• HIV 1 & 2
• HIV 1 and 2 Ab
• HIV type 1
• HIV type I
• HIV1
• HIV1+2
• Human immunodeficiency virus
• i
• ID
• II
• Immune globulin G
• Immunoglobulin G
• Infectious Disease
• InfectiousDisease
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• WB
• Whole blood

54087-2 Toxoplasma gondii IgG Ab [Presence] in DBS

Part Descriptions

LP14252-8   Toxoplasma gondii
Toxoplasma gondii is an intestinal coccidium that multiplies within cats as definitive hosts as well as within many other mammals and birds as intermediate hosts. T. gondii reproduces sexually only in cats. It infects the intestinal epithelium and produces oocysts which are shed in the feces. Humans acquire infections most often by consumption of undercooked meat containing tissue cysts or food contaminated by cat feces. Less than 0.1 percent of human cases are acquired congenitally. Toxoplasmosis is minor and self-limiting in immunocompetent individuals who may be asymptomatic or present with fever, lymphadenopathy, muscle aches and headache. Toxoplasma may manifest as encephalitis in immunosuppressed individuals including patients with acquired immune deficiency syndrome (AIDS) and may lead to coma or death. T. gondii often infects the brain and retina in congenitally infected children. Mild symptoms include slightly diminished vision while severely diseased children exhibit a pattern of retinochoroiditis, hydrocephalus, convulsions and intracerebral calcifications. Ocular disease may also occur. Toxoplasma is diagnosed through serology and upon histologic examination of tissues. Prevention includes thorough cooking of meat and proper management of cats. Sulfadiazine and pyrimethamine can be used to treat acute cases. [NCBI Books:NBK7627] Source: Regenstrief LOINC

Observation Required in Panel

Conditional

Fully-Specified Name

Component

Toxoplasma gondii Ab.IgG

Property

PrThr

Time

Pt

System

Bld.dot

Scale

Ord

Method

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.26

Last Updated

Version 2.61 (MIN)

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Member of these Panels

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• Blood
• DBS
• Dried blood spot
• Filter paper
• FP
• ID
• Immune globulin G
• Immunoglobulin G
• Infectious Disease
• InfectiousDisease
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• T gondii
• Toxo
• Toxoplasmosis
• WB
• Whole blood

54088-0 Toxoplasma gondii IgM Ab [Presence] in DBS

Part Descriptions

LP14252-8   Toxoplasma gondii
Toxoplasma gondii is an intestinal coccidium that multiplies within cats as definitive hosts as well as within many other mammals and birds as intermediate hosts. T. gondii reproduces sexually only in cats. It infects the intestinal epithelium and produces oocysts which are shed in the feces. Humans acquire infections most often by consumption of undercooked meat containing tissue cysts or food contaminated by cat feces. Less than 0.1 percent of human cases are acquired congenitally. Toxoplasmosis is minor and self-limiting in immunocompetent individuals who may be asymptomatic or present with fever, lymphadenopathy, muscle aches and headache. Toxoplasma may manifest as encephalitis in immunosuppressed individuals including patients with acquired immune deficiency syndrome (AIDS) and may lead to coma or death. T. gondii often infects the brain and retina in congenitally infected children. Mild symptoms include slightly diminished vision while severely diseased children exhibit a pattern of retinochoroiditis, hydrocephalus, convulsions and intracerebral calcifications. Ocular disease may also occur. Toxoplasma is diagnosed through serology and upon histologic examination of tissues. Prevention includes thorough cooking of meat and proper management of cats. Sulfadiazine and pyrimethamine can be used to treat acute cases. [NCBI Books:NBK7627] Source: Regenstrief LOINC

Observation Required in Panel

Conditional

Fully-Specified Name

Component

Toxoplasma gondii Ab.IgM

Property

PrThr

Time

Pt

System

Bld.dot

Scale

Ord

Method

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.26

Last Updated

Version 2.61 (MIN)

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Member of these Panels

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• Blood
• DBS
• Dried blood spot
• Filter paper
• FP
• ID
• Immune globulin M
• Immunoglobulin M
• Infectious Disease
• InfectiousDisease
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• T gondii
• Toxo
• Toxoplasmosis
• WB
• Whole blood

88535-0 Cytomegalovirus DNA [Presence] in DBS by NAA with probe detection

Term Description

Cytomegalovirus (CMV) DNA in dried blood spots can be used for retrospective diagnosis of congenital CMV, for example, in patients with unexplained childhood-onset hearing loss. Utility of the test in newborn screening for CMV infection has not been established. PMID: 25889596 Dried blood spot testing may also be used to monitor immunocompromised patients, such as those who have undergone organ transplant. PMID: 24483296

Part Descriptions

LP14255-1   Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.https://www.cdc.gov/cmv/overview.html Source: Regenstrief LOINC

Fully-Specified Name

Component

Cytomegalovirus DNA

Property

PrThr

Time

Pt

System

Bld.dot

Scale

Ord

Method

Probe.amp.tar

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.64

Last Updated

Version 2.64 (ADD)

Order vs. Observation

Both

Example Answer List LL7604-3

Member of these Panels

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• Blood
• CMV
• Cytomegalo virus
• Cytomgal
• DBS
• Deoxyribonucleic acid
• DNA NUCLEIC ACID PROBE
• DNA probe
• Dried blood spot
• Filter paper
• FP
• HHV-5
• Human Herpesvirus-5
• ID
• Infectious Disease
• InfectiousDisease
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Microbiology
• NAA+probe
• NAAT
• NASBA
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Screen
• SDA
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification
• WB
• Whole blood

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.