56451-8

Chymopapain IgG4 Ab [Mass/volume] in Serum

Active

Part Descriptions

LP15503-3 Chymopapain
A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6. Source: National Library of Medicine, MeSH 2006

LP15503-3 Chymopapain
Chymopapain is a proteolytic enzyme with a molecular weight of 27 kDa. It is extracted from a fraction of non-crystallised latex from a tropical tree, Carica papaya. Since 1965 it has been used to treat herniated disks through chemonucleolysis. Chemonucleolysis is a medical procedure that involves the dissolving of the gelatinous cushioning material in an intervertebral disk by the injection of an enzyme such as Chymopapain. A typical product for chemonucleolysis is Chymodiactin.

Chymopapain is the major active component of Papain. Because they have the same antigenic determinants, Papain and Chymopapain exhibit cross-reactivity. Chymopapain is more soluble and has greater proteolytic activity than Papain.

Chymopapain may commonly induce symptoms of allergy, including anaphylaxis and anaphylactoid reactions, in sensitised individuals undergoing chemonucleolysis. Although it has not been clinically investigated, there is a possibility of subsequent allergy to foods containing Chymopapain or closely related Papain. Copyright Copyright © 2006 Phadia AB. Source: ImmunoCap, ImmunoCap

LP32397-9 Ab.IgG4
IgG4 is the least common subtype of IgG, and it has a variety of functions. In the context of allergic disease it is thought to have an immune-inhibitory role in preventing anaphylaxis and is commonly known as a "blocking" antibody. IgG4 binding to an allergen can compete with IgE-mediated binding, thereby inhibiting the activation of mast cells and basophils and IgE-mediated presentation to T-cells. Measuring IgG4 and its ratio to IgE has a role in monitoring allergen specific immunotherapy PMID: 26023323. IgG4 is also thought to have a role in autoimmunity and be involved in a less defined entity known as IgG4-Related Disease, a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses .https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/igg4-related-disease/igg4-related-disease Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Chymopapain Ab.IgG4:MCnc:Pt:Ser:Qn:
Long Common Name: Chymopapain IgG4 Ab [Mass/volume] in Serum
Short Name: Chymopapain IgG4-mCnc
Display Name: Chymopapain IgG4 (S) [Mass/Vol]
Consumer Name Alpha Get Info: Chymopapain IgG4 antibody

Part Model Get Info

Component
Chymopapain Ab.IgG4
LP228028-9
- Analyte
  Chymopapain Ab.IgG4
  LP228028-9
  - Component Numerator
    Chymopapain Ab.IgG4
    LP228028-9
    - Component Numerator Core
      Chymopapain
      LP15503-3
    - Component Numerator Core Suffix
      Ab.IgG4
      LP32397-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: ALLERGY
Type: Laboratory
First Released: Version 2.29
Last Updated: Version 2.70 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Chymopapain Ab.IgG4:Hmotnostní koncentrace:Časový bod:Sérum:Kvantitativní:
el-GR	Greek (Greece)	Χυμοπαπαΐνη Ab.IgG4:MCnc:Pt:Ορός:Qn: Synonyms: Ab.IgG4 ALLERGY MCnc Pt Qn Αντίσωμα Ορός Χυμοπαπαΐνη
es-ES	Spanish (Spain)	Quimopapaina IgG4:Concentración de masa:Punto temporal:Suero:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Quimopapaína Ab.IgG4:Concentración de masa:Punto temporal:Suero:Cuantitativo:
et-EE	Estonian (Estonia)	Kümopapaiin antikehad.IgG4:MCnc:Pt:S:Qn: Synonyms: Juhuslik Kvantitatiivne Seerum
fr-CA	French (Canada)	Chymopapaïne, IgG4:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
fr-FR	French (France)	Chymopapaïne Ac IgG4:Masse/Volume:Ponctuel:Sérum:Numérique:
fr-BE	French (Belgium)	Chymopapaïne Anticorps. IgG4:Concentration de masse:Temps ponctuel:Sérum:Quantitatif: Synonyms: Anticorps
it-IT	Italian (Italy)	Chimopapaina Ab.IgG4:MCnc:Pt:Siero:Qn: Synonyms: Anticorpi IgG4 anticorpo Concentrazione di Massa Punto nel tempo (episodio) Risposta agli antigeni Siero
nl-NL	Dutch (Netherlands)	chymopapaïne As.IgG4:massa/volume:moment:serum:kwantitatief: Synonyms: antistof; antilichaam
pt-BR	Portuguese (Brazil)	Chymopapain Ac.IgG4:#N/A:Pt:Soro:Qn: Synonyms: Chymodiactin; c003; c3; Rc209; c209; Mass concentration; Level; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; ALLERGY TESTING; Allergens; Allergen
ru-RU	Russian (Russian Federation)	Химопапаин Ат.IgG4:МассКонц:ТчкВрм:Сыв:Колич: Synonyms: Антитело Количественный Массовая концентрация Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Kimopapain Ab.IgG4:KütlKons:Zmlı:Ser:Kant: Synonyms: Ak Ak.IgG4
zh-CN	Chinese (China)	木瓜凝乳蛋白酶抗体.IgG4:质量浓度:时间点:血清:定量型: Synonyms: Ab.IgG4;IgG4;抗体 IgG4 Ab;自身抗体可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间水平;浓度;质量浓度(单位体积) 糜木瓜酶

Example Units

Unit	Source
ug/mL	Example UCUM Units

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