6524-3
Rabies virus neutralizing antibody [Units/volume] in Serum by Neutralization test
Active
Part Descriptions
LP16737-6 Rabies virus
Rabies virus (RV), is an enveloped, single-stranded, negative sense RNA virus and a member of the Rhabdoviridae family. It is transmitted when an animal infected with RV bites an individual or the saliva from an infected animal comes into contact with an open wound. Once RV penetrates the muscle or connective tissue it begins to replicate and then infiltrates the peripheral nerves through the neuromuscular junction. From there, RV spreads to the central nervous system (CNS) in the endoneurium of the Schwann cells. If bitten by an animal that may have RV infection, rabies immune globulin and rabies vaccine should be administered. Otherwise, there is no treatment for infection by RV other than supportive care, and acute infection of the CNS is almost always fatal. In countries where preventative care is not practiced, RV is still widespread. In Asia, 30,000 people die annually from RV infection. Diagnosis of RV is done on two tissue specimens from the brain that are analyzed by direct fluorescent antibody (DFA), mouse inoculation, tissue culture and polymerase chain reaction.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307483/]
Source: Regenstrief LOINC
LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method.
Source: Regenstrief LOINC
LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Rabies virus Ab.Neut
- Property
- ACnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
- Neut
Additional Names
- Short Name
- RABV NAb Ser Nt-aCnc
- Display Name
- Rabies virus neut ab Neut test Qn (S)
- Consumer Name Alpha Get Info
- Rabies virus neutralizing antibody, Blood
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 1.0g
- Last Updated
- Version 2.73
- Change Reason
- Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 8424
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG32755-7 | Rabies virus |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: Rabiesvirus AK NT |
| de-DE | German (Germany) | Rabies-Virus Ak.neutralisierend: Synonyms: Rabies lyssavirus |
| es-AR | Spanish (Argentina) | [anticuerpo anti - ] virus de la rabia [Ac]: |
| es-ES | Spanish (Spain) | Virus de la Rabia Anticuerpos antineutrófilos: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Virus de la rabia Ab: |
| fr-FR | French (France) | Rage virus Ac neutralisant: |
| fr-CA | French (Canada) | Virus de la rage Ac.neut: |
| it-IT | Italian (Italy) | Rabbia, virus Ab.Neut: Synonyms: anticorpo Concentrazione Arbitraria Microbiologia Punto nel tempo (episodio) Siero Test di neutralizzazione Virus della rabbia |
| ko-KR | Korean (Korea, Republic Of) | 미친개병 바이러스 항체: |
| nl-NL | Dutch (Netherlands) | rabiësvirus As.neutraliserend: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Wirus wścieklizny Ab.Neutralizujące: Synonyms: Przeciwciała do wirusa wścieklizny Przeciwciała neutralizujące do wirusa wścieklizny |
| pt-BR | Portuguese (Brazil) | Raiva vírus Ac: Synonyms: ; |
| uk-UA | Ukrainian (Ukraine) | Вірус сказу Антитіла.Нейтралізуючі: Synonyms: ABS; |
| zh-CN | Chinese (China) | 狂犬病病毒 抗体.中和: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=6524-3
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