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Term Description

Rheumatoid arthritis disease activity score is based on the measurements of 12 serum proteins. An algorithm is applied to these concentrations to calculate a quantitative disease activity score ranging from 1 to 100. Test results are intended to aid in the assessment of disease activity in RA patients when used in conjunction with a standard clinical assessment. The test is not intended or validated to diagnose RA. This term is based on Crescendo BioScience's Vectra DA blood test for rheumatoid arthritis disease activity.

Part Description

LP185753-3   Rheumatoid arthritis disease activity score
The RA disease activity score is determined by a multi-biomarker disease activity (MBDA) algorithm, which was developed in a series of studies and clinically validated using the DAS28-CRP as a standard. The MBDA algorithm is as follows:

PTJC = Prediction of Tender Joint Count = −26.72+3.243 × [YKL-40]1/10 − 11.97 × [EGF]1/10 + 15.72 × [IL-6]1/10 + 0.4594 × [Leptin]1/10 + 3.881 × [SAA]1/10 + 0.7388 × [TNF-RI]1/10 − 0.2557 × [VCAM-1]1/10 + 0.7003 × [VEGF-A]1/10

PSJC = Prediction of Swollen Joint Count = −26.63 + 3.232 × [YKL-40]1/10 − 11.93 × [EGF]1/10 + 15.67 × [IL-6]1/10 + 0.4578 × [Leptin]1/10 + 3.868 × [SAA]1/10 + 0.7363 × [TNF-RI]1/10 − 0.2548 × [VCAM-1]1/10 + 0.6979 × [VEGF-A]1/10

PPGS = Prediction of Patient Global Score = -13.489 + 5.474 × [IL-6]1/10 + 0.486 × [SAA]1/10 + 2.246 × [MMP-1]1/10 + 1.684 × [Leptin]1/10 + 4.14 × [TNF-RI]1/10 + 2.292 × [VEGF-A]1/10 − 1.898 × [EGF]1/10 + 0.028 × [MMP-3]1/10 − 2.892 × [VCAM-1]1/10 − 0.506 × [Resistin]1/10

MBDA score = round(max(min((0.56 × sqrt(max(PTJC,0)) + 0.28 × sqrt(max(PSJC,0)) + 0.14 × PPGS + 0.36 × log(CRP/106 + 1)) × 10.53 + 1, 100),1))

The biomarker concentrations in the above formulas are expressed in pg/mL. All concentration values (except CRP) are transformed to the power 1/10 prior to use in the algorithm. MBDA scores are integers from 1 to 100 where 1 to 29 are considered low disease activity, 30 to 44 are moderate disease activity, and 45 to 100 are high disease activity. PMID: 22749821 Source: NCBI PubMed, PMID: 22749821

LOINC Names Get Info

Fully-Specified Name
Rheumatoid arthritis disease activity score:Score:Pt:Ser/Plas:SemiQn:Calculated.VectraDA
Long Common Name
Rheumatoid arthritis disease activity score Calculated by VectraDA
Short Name
RA DAS Score Calc VectraDA
Display Name
Rheumatoid arthritis disease activity score Calculated by VectraDA [Score]
Consumer Name Alpha Get Info
Rheumatoid arthritis disease activity score, Blood

Part Model Get Info

  • Component
    Rheumatoid arthritis disease activity score
    LP185753-3
    • Analyte
      Rheumatoid arthritis disease activity score
      LP185753-3
      • Component Numerator
        Rheumatoid arthritis disease activity score
        LP185753-3
        • Component Numerator Core
          Rheumatoid arthritis disease activity score
          LP185753-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Score
    LP185820-0
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Calculated.VectraDA
    LP189709-1

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.75 (MAJ)
Order vs. Observation
Observation
Common Test Rank Get Info
8457

Formula (Readable)

MBDA Score = round (max (min ((0.56 * sqrt (PTJC) + 0.28 * sqrt (PSJC) + 0.14 * PGH + 0.36 * log (CRP/10^6 + 1)) * 10.53 + 1, 100), 1))

Member of these Panels

LOINCLong Common Name
75635-3Rheumatoid arthritis disease activity panel - Serum or Plasma by VectraDA

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Revmatoidní artritida aktivita skóre:Skóre:Časový bod:Sérum/plazma:Semikvantitativní:Vypočteno pomocí testu VectraDA
el-GRGreek (Greece)Βαθμολογία ενεργότητας της νόσου της ρευματοειδούς αρθρίτιδας:Βαθμολογία:Pt:Ορός/Πλάσμα:Ημιποσοτική:Υπολογιζόμενο.VectraDA
Synonyms: CHEM Pt VectraDA Βαθμολογία Βαθμολογία ενεργότητας της νόσου της ρευματοειδούς αρθρίτιδας Δραστηριότητα Δραστηριότητα της ρευματοειδούς αρθρίτιδας Ημιποσοτική Ορός Ορός/Πλάσμα Πλάσμα Υπολογιζόμενο Υπολογιζόμενο.VectraDA
es-ESSpanish (Spain)Puntuación de actividad de la enfermedad artritis reumatoide:Puntuación:Punto temporal:Suero o Plasma:Semicuantitativo:Calculado por VectraDA
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Puntuación de actividad de la enfermedad de artritis reumatoide:Puntaje:Punto temporal:Suero o Plasma:Cuantitativo:Calculado por VectraDA
fr-FRFrench (France)Score d'activité de la polyarthrite rhumatoïde:Score:Ponctuel:Sérum/Plasma:Semi-Quantitatif:Test Vectra DA calcul
it-ITItalian (Italy)Artrite reumatoide, punteggio attività:Punteggio:Pt:Siero/Plasma:SemiQn:Calcolato.VectraDA
Synonyms: Calcolato mediante VectraDA Chimica Plasma Punteggio attività dell''artrite reumatoide Punto nel tempo (episodio) Siero Siero o Plasma
zh-CNChinese (China)类风湿性关节炎疾病活动度评分:评分:时间点:血清/血浆:半定量型:计算法.VectraDA
Synonyms: Crescendo BioScience Vectra DA 类风湿性关节炎病情活动血液检验项目;Crescendo BioScience''s Vectra DA blood test for rheumatoid arthritis disease activity RA 分值;分数;得分 分值;得分;分数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 时刻;随机;随意;瞬间 活动 疾 病 症 类风湿性关节炎（Rheumatoid arthritis，RA） 类风湿性关节炎（类风湿关节炎、RA）疾病活动度（活动）评分（分值、分数、得分）;类风湿性关节炎疾病活动指数;类风湿性关节炎 DAS;RA-DAS;DAS-RA 血清或血浆 计算;计算型方法

Example Units

UnitSource
{score}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75633-8