76546-1
Breast cancer 10-year risk of distant recurrence panel by Prosigna
Active
76397-9 Lymph node involvement
Term Description
Patients are allocated into two risk groups based on lymph node involvement; the risk group for node-negative patients, and the risk group for node-positive (1-3) patients. This term was created for, but not limited in use to, the Prosigna Breast Cancer Prognostic Gene Signature assay, which is based on the reported 50-gene classifier algorithm originally named PAM50.
Fully-Specified Name
- Component
- Lymph node involvement
- Property
- Find
- Time
- Pt
- System
- Lymph node
- Scale
- Ord
- Method
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 16471
Example Answer List LL3177-4
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Lymph node negative | LA21989-1 | ||
| Lymph node positive (1-3 positive nodes) | LA21990-9 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 76546-1 | Breast cancer 10-year risk of distant recurrence panel by Prosigna |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Συμμετοχή λεμφαδένων: Synonyms: Εύρεση Συμμετοχή λεμφαδένων |
| es-MX | Spanish (Mexico) | Compromiso de los ganglios linfáticos: |
| es-ES | Spanish (Spain) | Afectación de ganglios linfáticos: |
| fr-FR | French (France) | Ganglion lymphatique infiltration: |
| it-IT | Italian (Italy) | Interessamento del linfonodo: Synonyms: Coinvolgimento del linfonodo Osservazione Patologia Punto nel tempo (episodio) |
| zh-CN | Chinese (China) | 淋巴结累及: Synonyms: 依次型; |
21889-1 Size Tumor
Term Description
Part of the 10-digit EOD [779]. Detailed site-specific codes for anatomic EOD used by SEER for tumors diagnosed from 1988 forward. This field is included in the COC dataset, separate from EOD. Codes were revised effective January 1, 1998, to reflect changes in the AJCC Cancer Staging Manual, Fifth Edition.
Site-specific EOD codes provide extensive detail describing disease extent. The EOD codes can be grouped into different stage categories for analysis (e.g., historical summary stage categories consistent with those used in published SEER data since 1973, or more recently, AJCC stage groupings). The codes are updated as needed, but updates are usually backward compatible with old categories. See Comparative Staging Guide for Cancer.. NAACCR Data Standards and Data Dictionary Version 11
Fully-Specified Name
- Component
- Size
- Property
- Len
- Time
- Pt
- System
- Tumor
- Scale
- Qn
- Method
Basic Attributes
- Class
- TUMRRGT
- Type
- Clinical
- First Released
- Version 1.0m
- Last Updated
- Version 2.73 (MIN)
- Common Test Rank Get Info
- 19582
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 95556-7 | Adrenal cancer risk assessment and urine steroid fractions panel |
| 76546-1 | Breast cancer 10-year risk of distant recurrence panel by Prosigna |
| 85904-1 | Cancer pathology panel - Breast cancer specimen by CAP cancer protocols |
| 81186-9 | Gastric cancer pathology panel |
| 49083-9 | North American Association of Central Cancer Registries, Inc (NAACCR, Inc) version 11 panel |
| 59852-4 | North American Association of Central Cancer Registries, Inc (NAACCR, Inc) version 12 panel |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Μέγεθος: Synonyms: Len |
| es-AR | Spanish (Argentina) | tamaño: |
| es-MX | Spanish (Mexico) | Tamaño: |
| es-ES | Spanish (Spain) | Tamaño: Synonyms: Cuantitativo |
| it-IT | Italian (Italy) | Dimensione: Synonyms: Lunghezza Neoplasia Punto nel tempo (episodio) Registro tumori |
| nl-NL | Dutch (Netherlands) | afmeting: Synonyms: lengte |
| pt-BR | Portuguese (Brazil) | Tamanho: Synonyms: Length; |
| ru-RU | Russian (Russian Federation) | Размер: Synonyms: Длина Количественный Точка во времени; |
| tr-TR | Turkish (Turkey) | Büyüklük: Synonyms: Süre |
| zh-CN | Chinese (China) | 大小: Synonyms: NAACCR 肿瘤登记; |
Example Units
| Unit | Source |
|---|---|
| mm | Example UCUM Units |
76544-6 Breast cancer 10-year risk of distant recurrence score Calculated by Prosigna
Term Description
The 10-year breast cancer distant recurrence risk score (also referred to as ROR Score or Risk of Recurrence Score) is a numerical score on a scale of 0 -100 that is calculated using a statistical model that includes: 1) the results from a 50-gene expression assay performed on formalin fixed paraffin embedded breast tumor tissue previously diagnosed as invasive carcinoma; 2) proliferation score; and 3) gross tumor size. The calculated score and information about lymph node status are used together to classify the patient into a risk category for distant breast cancer recurrence at 10 years. This term was created for the Prosigna™ Breast Cancer Prognostic Gene Signature assay, which is intended for use in postmenopausal women with node-negative (Stage I or II) or node-positive (Stage II), hormone receptor-positive (HR+) breast cancer who have undergone surgery and are to be treated with adjuvant endocrine therapy alone.
Fully-Specified Name
- Component
- Breast cancer 10Y risk of distant recurrence score
- Property
- Score
- Time
- Pt
- System
- ^Patient
- Scale
- Qn
- Method
- Calculated.Prosigna
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- Order_Obs: changed from 'observation' to 'both' to reflect that the LOINC code can also be used as an order code.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 17578
Formula (Readable)
Calculated using a Cox model that includes coefficients for the gene expression assay results, proliferation score, and gross tumor size.
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 76546-1 | Breast cancer 10-year risk of distant recurrence panel by Prosigna |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Κίνδυνος απομακρυσμένης υποτροπής του καρκίνου του μαστού σε 10 έτη: Synonyms: Βαθμολογία Καρκίνος Κίνδυνος απομακρυσμένης υποτροπής του καρκίνου του μαστού σε 10 έτη |
| es-MX | Spanish (Mexico) | Puntuación de riesgo de recidiva a distancia de 10 años de cáncer de mama: |
| es-ES | Spanish (Spain) | Ratio del riesgo de recurrencia a 10 años en el cáncer de mama: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cancer du sein score des risques de récidive sur 10 ans: |
| it-IT | Italian (Italy) | Tumore della mammella, rischio 10 anni di recidive tumorali, punteggio: Synonyms: Calcolato mediante Prosigna Patologia molecolare paziente Punto nel tempo (episodio) |
| zh-CN | Chinese (China) | 乳腺癌远处转移 10 年风险评分: Synonyms: Prosigna 法 乳腺癌远处转移（远程转移） 10 年风险（危险性、 |
Example Units
| Unit | Source |
|---|---|
| {score} | Example UCUM Units |
76545-3 Breast cancer 10-year risk of distant recurrence classification [Interpretation] Qualitative by Prosigna
Term Description
The risk classification is an ordinal risk category (low, intermediate, high) that indicates a patient's risk of recurrence of breast cancer at 10 years. The classification is based on the 10-year risk of distant recurrence score and lymph node status. Low risk is associated with a 3% chance (confidence interval 2-6%), intermediate risk is associated with a 10% chance (confidence interval 7-14%), and high risk with a 16% chance (confidence interval 11-22%) of distant breast cancer recurrence at 10 years, respectively. PMID: 24347518 This term was created for the Prosigna™ Breast Cancer Prognostic Gene Signature assay, which is intended for use in postmenopausal women with node-negative (Stage I or II) or node-positive (Stage II), hormone receptor-positive (HR+) breast cancer who have undergone surgery and are to be treated with adjuvant endocrine therapy alone.
Fully-Specified Name
- Component
- Breast cancer 10Y risk of distant recurrence classification
- Property
- Imp
- Time
- Pt
- System
- ^Patient
- Scale
- Ord
- Method
- Prosigna
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 18127
Normative Answer List LL3198-0
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| High risk | LA19541-4 | ||
| Intermediate risk | LA22380-2 | ||
| Low risk | LA19542-2 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 76546-1 | Breast cancer 10-year risk of distant recurrence panel by Prosigna |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Κατηγοριοποίηση κινδύνου απομακρυσμένης υποτροπής του καρκίνου του μαστού σε 10 έτη: Synonyms: Imp Καρκίνος Κατηγοριοποίηση κινδύνου απομακρυσμένης υποτροπής του καρκίνου του μαστού σε 10 έτη |
| es-MX | Spanish (Mexico) | Clasificación de riesgo de recidiva distante 10 años del cáncer de mama: |
| es-ES | Spanish (Spain) | Clasificación del riesgo de recurrencia a 10 años en el cáncer de mama: |
| fr-FR | French (France) | Cancer du sein classification des risques de récidive sur 10 ans: |
| it-IT | Italian (Italy) | Tumore della mammella, rischio 10 anni di recidive tumorali, classificazione: Synonyms: Impressione/interpretazione di studio Patologia molecolare paziente Punto nel tempo (episodio) |
| zh-CN | Chinese (China) | 乳腺癌远处转移 10 年风险分类: Synonyms: Prosigna 法 乳腺癌远处转移（远程转移） 10 年风险（危险性、 |