LOINC
Version 2.72

78203-7BCL6 gene rearrangements [Presence] in Blood or Tissue by FISHActive

Term Description

This term was created for, but is not limited in use to, the LSI BCL6 (ABR) Dual Color, Break Apart Rearrangement Probe, which is intended to detect rearrangements in the BCL6 gene in the 3q27 chromosome region.
Source: Regenstrief LOINC

Part Descriptions

LP19776-1   BCL6 gene rearrangements
The protein encoded by the BCL6 gene arrangements is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. Source: National Center for Biotechnology Information (NCBI) Gene, BCL6 gene rearrangements

LP19776-1   BCL6 gene rearrangements
The BCL6 gene (B-cell CLL/lymphoma 6) [HGNC Gene ID:1001] is located on chromosome 3q27. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] [NCBI Gene ID:604] Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Source: National Center for Biotechnology Information (NCBI) Gene, Link to OMIM

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
BCL6 gene rearrangements
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
FISH

Additional Names

Short Name
BCL6 gene Rear Bld/T Ql FISH
Display Name
BCL6 rearrangements FISH Ql (Bld/Tiss)
Consumer Name Alpha
BCL6 rearrangements, Blood or tissue specimen

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.61
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
BCL6 基因重排:存在情况或阈值:时间点:全血/组织:序数型:FISH
nl-NLDutch (Netherlands)
BCL6-gentranslocaties:aanwezigheid:moment:bloed of weefsel:ordinaal:FISH
et-EEEstonian (Estonia)
BCL6 geeni muudatused:PrThr:Pt:B/Tis:Ord:FISH
fr-FRFrench (France)
BCL6 gène réarrangements:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:FISH
it-ITItalian (Italy)
BCL6, riarrangiamenti gene:PrThr:Pt:Sangue/Tess:Ord:FISH
es-MXSpanish (Mexico)
Reordenamientos del gen BCL6:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Hibridación fluorescente in situ (FISH)
es-ESSpanish (Spain)
Reordenamientos del gen BCL6:PrThr:Punto temporal:Sangre o tejido:Ord:Hibridación in situ fluoresente (FISH)
tr-TRTurkish (Turkey)
BCL6 geni yeniden düzenlenmeler:MevcEşik:Zmlı:Kan/Dk:Srl:FISH

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78203-7