Version 2.77

Term Description

This term was created for, but is not limited in use to, the Vysis MYC Break Apart FISH Probe Kit, which is intended for use in identifying MYC gene rearrangements.
Source: Regenstrief LOINC

Part Descriptions

LP19780-3   MYC gene rearrangements
The MYC gene (v-myc avian myelocytomatosis viral oncogene homolog) [HGNC Gene ID:7553] is located on chromosome 8q24.21. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:4609] Source: National Center for Biotechnology Information (NCBI) Gene

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
MYC gene rearrangements
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
FISH

Additional Names

Short Name
MYC gene Rear Bld/T Ql FISH
Display Name
MYC gene rearrangements FISH Ql (Bld/Tiss)
Consumer Name Alpha Get Info
MYC gene rearrangements, Blood or tissue specimen

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
6873

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Reordenamientos del gen MYC:PrThr:Punto temporal:Sangre o tejido:Ord:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Reordenamientos del gen MYC:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Hibridación fluorescente in situ (FISH)
et-EE Estonian (Estonia) MYC geeni muudatused:PrThr:Pt:B/Tis:Ord:FISH
Synonyms: Järgarvuline Juhuslik Kude Veri Veri või koematerjal
fr-FR French (France) MYC gène réarrangements:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:FISH
it-IT Italian (Italy) MYC, riarrangiamenti gene:PrThr:Pt:Sangue/Tess:Ord:FISH
Synonyms: Gene MYC Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Riarrangiamenti gene MYC Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) MYC genherschikking:aanwezigheid:moment:bloed of weefsel:ordinaal:FISH
Synonyms: MYC gen MYC gentranslocatie
tr-TR Turkish (Turkey) MYC geni yeniden düzenlemeler:MevcEşik:Zmlı:Kan/Dk:Srl:FISH
Synonyms: Mevcut
zh-CN Chinese (China) MYC 基因重排:存在情况或阈值:时间点:全血/组织:序数型:FISH
Synonyms: Burkitt 淋巴瘤 Burkitts 淋巴瘤 c-MYC Fluorescent in situ hybridization;荧光原位杂交 MYC 原癌基因 MYC 基因重排(重组) v-myc myelocytomatosis viral oncogene homolog (avian);MYC;MRTL;bHLHe39;c-Myc;avian myelocytomatosis viral oncogene homolog;class E basic helix-loop-helix protein 39;myc proto-oncogene protein;myc-related translation/localization regulatory factor;proto-on v-myc 骨髓细胞瘤病毒原癌基因同源基因 v-myc 骨髓细胞瘤病毒原癌基因同源基因(v-myc myelocytomatosis viral oncogene homolog) v-myc 髓细胞瘤病毒原癌基因同源基因 v-myc 髓细胞组织增生病毒原癌基因同源基因 v-myc 髓细胞组织增生症病毒原癌基因同源基因 与骨髓细胞瘤病毒同源的原癌基因 与骨髓细胞瘤病毒同源的原癌基因(Protooncogene homologous to myelocytomatosis virus) 与髓细胞瘤病毒同源的原癌基因 与髓细胞组织增生病毒同源的原癌基因 与髓细胞组织增生症病毒同源的原癌基因 伯基特氏淋巴瘤 伯基特淋巴瘤 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排 分子病理学;分子病理学试验 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因 骨髓细胞瘤病毒同源原癌基因 髓细胞瘤病毒同源原癌基因 髓细胞组织增生病毒同源原癌基因 髓细胞组织增生症病毒同源原癌基因

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