78218-5BCL2 gene rearrangements [Presence] in Blood or Tissue by FISHActive
Term Description
This term was created for, but is not limited in use to, the Vysis BCL2 Break Apart FISH Probe Kit, which is intended to detect chromosomal rearrangements at the BCL2 locus on chromosome region 18q21.
Source: Regenstrief LOINC
Part Descriptions
LP19775-3 BCL2 gene rearrangements
The BCL2 gene (B-cell CLL/lymphoma 2) [HGNC Gene ID:990] is located on chromosome 18q21.3. This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008] [NCBI Gene ID:596]
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Source: National Center for Biotechnology Information (NCBI) Gene, FISH
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, FISH
Fully-Specified Name
- Component
- BCL2 gene rearrangements
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- FISH
Additional Names
- Short Name
- BCL2 gene Rear Bld/T Ql FISH
- Display Name
- BCL2 rearrangements FISH Ql (Bld/Tiss)
- Consumer Name Alpha
- BCL2 rearrangements, Blood or tissue specimen
Example Answer List LL744-4
Source: Regenstrief Institute
Answer | Code | Score | Answer ID |
---|---|---|---|
Detected | LA11882-0 | ||
Not detected | LA11883-8 |
Basic Attributes
- Class
- MOLPATH.REARRANGE
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.61
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
- zh-CNChinese (China)
- BCL2 基因重排:
存在情况或阈值: 时间点: 全血/组织: 序数型: FISH - nl-NLDutch (Netherlands)
- BCL2-gentranslocaties:
aanwezigheid: moment: bloed of weefsel: ordinaal: FISH - et-EEEstonian (Estonia)
- BCL2 geeni muudatused:
PrThr: Pt: B/Tis: Ord: FISH - fr-FRFrench (France)
- BCL2 gène réarrangements:
Présence/Seuil: Ponctuel: Sang/Tissu: Qualitatif: FISH - it-ITItalian (Italy)
- BCL2, riarrangiamenti gene:
PrThr: Pt: Sangue/Tess: Ord: FISH - es-MXSpanish (Mexico)
- Reordenamientos del gen BCL2:
Presencia o umbral: Punto temporal: Sangre o tejido: Ordinal: Hibridación fluorescente in situ (FISH) - es-ESSpanish (Spain)
- Reordenamientos del gen BCL2:
PrThr: Punto temporal: Sangre o tejido: Ord: Hibridación in situ fluoresente (FISH) - tr-TRTurkish (Turkey)
- BCL2 geni yeniden düzenlenmeler:
MevcEşik: Zmlı: Kan/Dk: Srl: FISH
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78218-5
LOINC Copyright
Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright