Version 2.78

Term Description

This term was created for the HepaScore liver fibrosis test, which is a marker of liver fibrosis in patients with hepatitis C infection. The score ranges from 0 to 1 and is calculated based on four lab tests (GGT, bilirubin, alpha-2-macroglobulin, and hyaluronic acid) plus the patient's age and gender. The HepaScore is reported with a central cut-off of 0.50, with a value ≥ 0.50 indicating that significant liver fibrosis is present (positive predictive value 88%) and a value < 0.50 indicating that advanced fibrosis is absent (negative predictive value 95%) for patients with hepatitis C infection. The HepaScore logistic regression model is as follows: y = exp[-4.185818 - (0.0249 x age) + (0.7464 x sex) + (1.0039 x α2-macroglobulin) + (0.0302 x hyaluronic acid) + (0.0691 x bilirubin) - (0.0012 x GGT)]
with age provided in years, male sex = 1, female sex = 0, α2-macroglobulin in g/L, hyaluronate in μg/L, bilirubin in μmol/L, and GGT in U/L. The score itself is calculated as y/(1 +y). PMID: 16055434
Source: Regenstrief LOINC

Part Description

LP193274-0   Liver fibrosis score
A liver fibrosis score is a noninvasive method used to determine the presence and degree of liver fibrosis in a patient based on a variety of different parameters (e.g., lab tests, age, and gender) depending on the method used. PMID: 21254180. Different methods used to calculate a patient's liver fibrosis score include the Enhanced Liver Fibrosis (ELF) test, nonalcoholic fatty liver disease (NAFLD) fibrosis score, HepaScore, FibroMeter, and FibroSURE. Source: Regenstrief LOINC

Fully-Specified Name

Component
Liver fibrosis score
Property
Score
Time
Pt
System
Ser/Plas
Scale
Qn
Method
Calculated.HepaScore

Additional Names

Short Name
Liver fibr score SerPl Calc HepaScore
Display Name
Liver fibrosis score Calculated by HepaScore [Score]
Consumer Name Alpha Get Info
Liver fibrosis score, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54
Order vs. Observation
Both

Formula (Readable)

HepaScore = y/(1+y), where y = exp[-4.185818 - (0.0249 x age) + (0.7464 x sex) + (1.0039 x α2-macroglobulin) + (0.0302 x hyaluronic acid) + (0.0691 x bilirubin) - (0.0012 x GGT)]

Member of these Panels

LOINC Long Common Name
78698-8 Liver fibrosis score panel - Serum or Plasma Calculated by HepaScore

Member of these Groups Get Info

LOINC Group Group Name
LG19496-5 Liver fibrosis score|Score|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Puntuación fibrosis hepática:Puntuación:Punto temporal:Suero o Plasma:Qn:Calculado por HepaScore
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Puntuación de fibrosis hepática:Puntaje:Punto temporal:Suero o Plasma:Cuantitativo:Calculado por HepaScore
fr-FR French (France) Score de fibrose hépatique:Score:Ponctuel:Sérum/Plasma:Numérique:Calcul par Hepascore
it-IT Italian (Italy) Fibrosi epatica, punteggio:Punteggio:Pt:Siero/Plasma:Qn:Calcolato.HepaScore
Synonyms: Calcolato mediante HepaScore Chimica Plasma Punteggio di fibrosi Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 肝纤维化评分:评分:时间点:血清/血浆:定量型:计算法.HepaScore
Synonyms: 分值;分数;得分 分值;得分;分数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 纤维化分值;纤维化得分;纤维变性评分（分值、得分、分数）;纤维化评分 肝 肝纤维化（肝脏纤维化、肝纤维症）评分（分值、得分、分数） 血清或血浆 计算;计算型方法

Example Units

Unit Source
{score} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78894-3