Version 2.78

Term Description

This term was created for, but is not limited in use to, Nanosphere's Verigene Enteric Pathogens Nucleic Acid Test, which is intended for the detection and identification of common pathogenic enteric bacteria, viruses, and genetic virulence markers in stool specimens from individuals with signs and symptoms of gastrointestinal infection.
Source: Regenstrief LOINC

Part Description

LP262487-4   Escherichia coli Stx1 toxin stx1 gene
The Stx1 toxin A subunit is encoded by the stx1 gene [www.uniprot.org/uniprot/ ?query=stx1+escherichia+coli&sort=score] and the Stx2 toxin A subunit is encoded by the stx2 gene.[UniProt: K0JD26] Stx1a and Stx2a are produced by some serogroups of Escherichia coli (also known as Vero toxins and previously referred to as Shiga-like toxins) are two cytotoxins that cause hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The two toxins produce similar symptoms, but are immunologically unique. Both toxins are composed of a single copy of subunit A and five copies of subunit B. Stx1a and Stx1b induce host cell apoptosis by removing an adenine residue from the 28S rRNA of the 60S ribosome, with RNA-N-glycosidase activity provided by subunit A. The five B subunits bind to the host cell receptor present on endothelial cells. PMID: 25530917 Shigella toxin-producing Escherichia coli (STEC) has become a serious food-borne pathogen. Outbreaks of STEC have been associated with the consumption of pork products resulting in HC and HUS. STEC in swine has been demonstrated to cause edema disease. Epidemiological studies throughout the world have proven that STEC can be harbored and shed by domestic swine. PMID: 24397985 Source: Regenstrief LOINC

Fully-Specified Name

Component
Escherichia coli Stx1 toxin stx1 gene
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
EC stx1 gene Stl Ql NAA+probe
Display Name
E. coli stx1 gene NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Escherichia coli stx1 toxin stx1 gene, Stool

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Change Reason
Changed Component from "Bacterial shiga-like toxin 1 (stx1) gene" to "Escherichia coli shiga-like toxin 1 (stx1) gene" since stx1 is only produced by E.coli.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Component from "Escherichia coli shiga-like toxin 1 (stx1) gene" based on the current E. coli nomenclature and LOINC model.
Order vs. Observation
Observation
Common Test Rank Get Info
4123

Member of these Panels

LOINC Long Common Name
81659-5 Escherichia coli Stx1 and Stx2 toxin stx1 and stx2 genes panel - Stool by NAA with probe detection
79381-0 Gastrointestinal pathogens panel - Stool by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Escherichia coli Stx1 Toxin stx1-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Stuhl:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-ES Spanish (Spain) Gen stx1 Escherichia coli:PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Escherichia coli Toxina Stx1 Gen stx1:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Escherichia coli toxine stx1 gène:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Escherichia coli tossina Stx1, gene stx1:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Escherichia coli Stx1-toxine stx1-gen:aanwezigheid:moment:feces:ordinaal:probe-detectie
Synonyms: ontlasting; feces probe.amp.tar
zh-CN Chinese (China) 大肠埃希菌 Stx1 毒素 stx1 基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: E coli;大肠埃希氏杆菌;大肠埃希氏菌;大肠杆菌 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 大肠埃希菌（E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌） Stx1 毒素 stx1 基因;大肠埃希菌 stx1 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79386-9