81281-8
Heparin dose response panel - Blood
Active
81639-7 Heparin dose response slope in Blood by Coagulation assay
Term Description
The heparin dose response slope is a measure of the increase in the clotting time of fresh whole blood as the heparin concentration is raised to a known value. The slope is measured in seconds of increase/unit of heparin/mL of blood volume.
Observation Required in Panel
Optional
Fully-Specified Name
- Component
- Heparin dose response slope
- Property
- Arb
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- Coag
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.56 (ADD)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 81281-8 | Heparin dose response panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Sklon křivky odpovědi na dávku heparinu: |
| el-GR | Greek (Greece) | Κλίση απόκρισης σε δόση ηπαρίνης: Synonyms: Arb Coag Pt Qn Αίμα Ηπαρίνη Κλίση Κλίση απόκρισης σε δόση ηπαρίνης |
| es-ES | Spanish (Spain) | Pendiente de la respuesta a la dosis de heparina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Pendiente de respuesta a la dosis de heparina: |
| fr-FR | French (France) | Cinétique augmentation dose héparine: |
| it-IT | Italian (Italy) | Curva di risposta alla dose di eparina: Synonyms: Arbitrario Punto nel tempo (episodio) Sangue Studio di coagulazione Test di coagulazione |
| pl-PL | Polish (Poland) | Nachylenie krzywej odpowiedzi na dawkę heparyny: |
| zh-CN | Chinese (China) | 肝素剂量反应斜率: Synonyms: 一剂物质 一剂药物 任意; |
Example Units
| Unit | Source |
|---|---|
| s/U/mL | Example UCUM Units |
80659-6 Activated clotting time (ACT) of Blood induced by Kaolin
Term Description
The activated clotting time (ACT) of blood is a measure of the amount of time for a fibrin clot to form in the presence of a known amount of kaolin activator.
Part Descriptions
LP207644-8 Activated clotting time
The activated clotting time (ACT) measures the time to clot formation after addition of an activator, and is used primarily to monitor a patient's coagulation status during surgery, especially procedures during which patients are on cardiopulmonary bypass. The activator may stimulate the intrinsic and/or extrinsic coagulation pathway, and commonly used activators include kaolin, Celite and glass beads. Various anticoagulant drugs can be used to prevent clot formation and consumption of platelets during surgery. The most common is unfractionated heparin because it has a short half-life and is easily reversed. Baseline ACT and subsequent ACT measurements during and after the procedure help determine the initial heparin dose and titration parameters to achieve a stable level of anticoagulation during surgery, as well as appropriate reversal of anticoagulation after surgery. The ACT can be affected by platelet count, platelet function, temperature of the blood, and acquired or inherited hematologic conditions. The ACT is a point of care test used to monitor patients receiving high doses of heparin in an acute setting, while partial thromboplastin time (PTT) is used to monitor patients who are on lower, long-term therapeutic doses of heparin.
Source: Regenstrief LOINC, Lab Tests Online: Activated Clotting Time
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Activated clotting time
- Property
- Time
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- Coag.kaolin induced
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.82 (NAM)
- Change Reason
- Release 2.69: METHOD_TYP: Make model consistent with new Microviscometry terms.; COMPONENT: Make model consistent with new Microviscometry terms.;
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 14245
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 81281-8 | Heparin dose response panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Aktivovaný koagulační čas (ACT).kaolinem indukovaný: |
| el-GR | Greek (Greece) | Ενεργοποιημένος χρόνος πήξης.προκληθείς από καολίνη: Synonyms: Coag Pt Qn Time Αίμα Ενεργοποιημένος χρόνος πήξης Ενεργοποιημένος χρόνος πήξης.προκληθείς από καολίνη Χρόνος πήξης |
| es-ES | Spanish (Spain) | Tiempo de activación del coágulo: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Tiempo de coagulación activado inducido por caolín: |
| fr-CA | French (Canada) | Temps de la coagulation activée: |
| fr-FR | French (France) | Temps de coagulation activé induit par le kaolin: |
| it-IT | Italian (Italy) | Tempo di coagulazione attivato: Synonyms: Coagulazione indotta da caolino Punto nel tempo (episodio) Sangue Studio di coagulazione Tempo (e.g. secondi) Test di coagulazione |
| nl-NL | Dutch (Netherlands) | geactiveerde stollingstijd: Synonyms: ACT; |
| pl-PL | Polish (Poland) | Aktywowany czas krzepnięcia.indukowany kaolinem: Synonyms: Aktywowany czas krzepnięcia indukowany kaolinem |
| zh-CN | Chinese (China) | 活化凝血时间: Synonyms: ACT; |
Example Units
| Unit | Source |
|---|---|
| s | Example UCUM Units |
80893-1 Projected heparin concentration to reach target ACT [Units/volume] in Blood by calculation
Term Description
The projected heparin concentration is the amount of heparin required to increase the patient's ACT to the clinician specified target value and is based the target ACT and the slope of the patient's response to known amounts of heparin. This term was created for, but is not limited in use to, the submitter's Medtronic Heparin Dose Response test kit.
Part Descriptions
LP206571-4 Projected heparin concentration to reach target ACT
The projected heparin dose response test is a point-of-care test performed on fresh whole blood (no citrate added) to assess patient's individual response to heparin. The test measures the baseline (no heparin) activated clotting time, and the activated clotting times on the same blood to which 2 different concentrations of unfractionated heparin is added. From these measurements a projected dose response is calculated. This test is used in the cardiac operating room where patients are anticoagulated with high (3 to 5 units heparin/mL of blood) levels of unfractionated heparin. The effect of this level of heparin anticoagulation is measured every 20 to 30 minutes while the patient is on cardiopulmonary bypass. The heparin dose response is used to determine the appropriate amount of heparin needed to increase the patient's activated clotting time to the target level used by the hospital. The heparin dose response test is typically performed once at the beginning of the surgical procedure before the patient is placed on bypass. Once the patient is heparinized and placed on bypass the activated clotting time and the heparin concentration (whole blood heparin assay) are determined in the operating room every 20 to 30 minutes during the procedure. Heparin administered to patients in the cardiac OR is unfractionated, not low molecular weight. The amount given greatly exceeds the amount that could be monitored by the APTT. In this setting the most important concern is that the patient receive the appropriate amount in order to reach and maintain the required anticoagulant (thrombin inhibiting) protection.
Source: Regenstrief LOINC
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Projected heparin concentration to reach target ACT
- Property
- ACnc
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- Calculated
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.68 (MIN)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 81281-8 | Heparin dose response panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Heparin předpokládaná koncentrace k dosažení cílové ACT: |
| el-GR | Greek (Greece) | Προβλεπόμενη συγκέντρωση ηπαρίνης για την επίτευξη του ενεργοποιημένου χρόνου πήξης-στόχου: Synonyms: ACnc COAG Pt Qn Αίμα Ηπαρίνη Προβλεπόμενη συγκέντρωση ηπαρίνης για την επίτευξη του ενεργοποιημένου χρόνου πήξης-στόχου Υπολογιζόμενο |
| es-ES | Spanish (Spain) | Concentración de heparina prevista para alcanzar el objetivo ACT: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Concentración de heparina proyectada para alcanzar el ACT objetivo: |
| fr-FR | French (France) | Héparine concentration pour TCA cible: |
| fr-CA | French (Canada) | Héparine concentration pour TCA cible: |
| it-IT | Italian (Italy) | Concentrazione di eparina prevista per raggiungere il target ACT: Synonyms: Concentrazione Arbitraria Punto nel tempo (episodio) Sangue Studio di coagulazione |
| zh-CN | Chinese (China) | 达到活化凝血时间的预计肝素浓度: Synonyms: 任意型浓度(单位体积); |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |