Version 2.78

Part Description

LP212216-8   Microsatellite instability marker D5S346
Microsatellite instability (MSI) is a change in the number of repeats of a specific DNA marker in cancer cells compared to the number of repeats present in non-cancerous cells of the same patient. Different tumor types are associated with different MSI markers, and both the presence of MSI in specific markers as well as the the number of distinct markers demonstrating MSI is important. Tumor cells are classified as being stable, having high instability (MSI-H), or having low instability (MSI-L) based on the number of markers demonstrating MSI. MSI analysis may help guide therapy and be a prognostic indicator. Specific MSI markers include BAT25, BAT26, D2S123, D5S346, D17S2720, NR21, NR24 and MONO27. MSI has been most studied in colorectal cancer, and colorectal tumors that are MSI-H are more likely to be carcinomas than adenomas. MSI has also been studied in other types of cancer, including gastric cancer, breast cancer, lung cancer and Wilms tumor. Source: Regenstrief LOINC

Fully-Specified Name

Component
Microsatellite instability marker D5S346
Property
Find
Time
Pt
System
Cancer specimen
Scale
Ord
Method

Additional Names

Short Name
MSI mark D5S346 Ca spec Ql
Display Name
Microsatellite instability marker D5S346 Ql (Cancer specimen)
Consumer Name Alpha Get Info
Microsatellite Instability Marker D5S346, Cancer specimen

Example Answer List: LL1057-0

Source: Regenstrief LOINC
Answer Code Score Answer ID
Stable LA14122-8
Unstable LA14123-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.61
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because MSI testing is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85905-8 Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols
81711-4 Microsatellite instability marker panel - Cancer specimen

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Marcador D5S346 de inestabilidad de microsatélites:Hallazgo:Punto temporal:Muestra de cancer:Ord:
es-MX Spanish (Mexico) Marcador de inestabilidad de microsatélites D5S346:Hallazgo:Punto temporal:Espécimen de cáncer:Ordinal:
it-IT Italian (Italy) Marcatore D5S346 di instabilità dei microsatelliti:Osservazione:Pt:Campione tumore:Ord:
Synonyms: Campione di tumore Instabilità dei microsatelliti Neoplasia maligna Osservazione Patologia Punto nel tempo (episodio)
zh-CN Chinese (China) 微卫星不稳定性标记 D5S346:发现:时间点:癌标本:序数型:
Synonyms: MSI 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 受检物 微卫星不稳定性（MSI）标记（标记物、标志、标志物） D5S346 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81703-1