Version 2.77

Part Description

LP220247-3   Daclatasvir
Daclatasvir (also called DCV, formerly called BMS-790052, tradename Daklinza) is a first-generation, direct-acting antiviral (DAA) is a zinc-binding and proline-rich hydrophilic phosphoprotein that plays a key role in hepatitis C virus RNA replication. Daclatasvir is used along with other medications, such as sofosbuvir (tradename Solvadi), to treat certain types of chronic hepatitis C. Treatment stops the virus from multiplying and in turn prevents secondary diseases of hepatitis C, including cirrhosis and liver cancer. Patients who have no detectable virus in the blood for a longer a period following treatment may be at lower risk of such secondary diseases. Six different forms of hepatitis C viruses are now known, referred to as genotypes 1 to 6. In clinical studies, the baseline NS5A polymorphism Y93H resulted in reduced rates of sustained virologic response in patients with HCV genotype 3 who were treated for 12 weeks with daclatasvir (plus sofosbuvir), especially in those patients with cirrhosis. In addition, the high mutation rate of the HCV genome, combined with selective pressure from ongoing therapy, can lead to selection of additional HCV variants that are resistant to NS5A inhibitors. PMID: 24659881 Source: Regenstrief LOINC

Fully-Specified Name

Component
Daclatasvir
Property
Susc
Time
Pt
System
Isolate
Scale
Ord
Method
Genotyping

Additional Names

Short Name
Daclatasvir Islt Genotyp
Display Name
Daclatasvir Genotyping [Susc]
Consumer Name Alpha Get Info
Susceptibility to Daclatasvir

Example Answer List: LL4039-5

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
Resistance predicted LA26373-3
Resistance not predicted LA26374-1

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
8433

Member of these Panels

LOINC Long Common Name
82525-7 Hepatitis C virus genotype and drug resistance panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Dataclasvir:Susceptibilidad:Punto temporal:Aislado:Ord:Susceptibilidad al genotipo viral
es-MX Spanish (Mexico) Daclatasvir:Susceptibilidad (microorganismos):Punto temporal:Aislado:Ordinal:Susceptibilidad del genotipo viral
fr-FR French (France) Daclatasvir:Sensibilité:Ponctuel:Isolat:Qualitatif:Génotypage
it-IT Italian (Italy) Daclatasvir:Susc:Pt:Isolato:Ord:Genotipizzazione
Synonyms: Punto nel tempo (episodio) Sensibilità (microrganismi) Suscettibilità agli antibiotici Suscettibilità al genotipo virale
nl-NL Dutch (Netherlands) daclatasvir:gevoeligheid:moment:isolaat:ordinaal:genotypering
zh-CN Chinese (China) 达卡他韦:抗生素敏感性:时间点:分离株:序数型:基因分型
Synonyms: N,N''-[[1,1''-联苯]-4,4''-二基双[1H-咪唑-5,2-二基-(2S)-2,1-吡咯烷二基 [(1S)-1-(1-甲基乙基)-2-氧代-2,1-乙烷二基]]]双氨基甲酸 C,C''-二甲酯;CAS 1009119-64-5 (1214735-16-6);BMS 790052;EBP 883;Daklinza;N,N''-[[1,1''-Biphenyl]-4,4''-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)- 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分离物;分离菌;分离菌株;隔离种群 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 抗生素敏感性(微生物);敏感性;某种抗微生物制剂对于某个分离株的影响;药物敏感性;药物敏感性(微生物) 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82379-9