Version 2.80

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Descriptions

LP157213-2   Centromere protein A Ab
Centromere protein A, also known as Histone H3-like centromeric protein A (CENP-A), replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. It is required for recruitment and assembly of kinetochore proteins, progression of mitosis and segregation of chromosomes. [UniProt: P49450] Anti-CENP-A antibodies are a marker of systemic sclerosis (SSc), a multisystem autoimmune connective tissue disorder that is characterized by vascular abnormalities, excessive collagen synthesis, and autoantibodies to nuclear and nucleolar proteins. Approximately 20-40% of patients with SSc are positive for anti-CENP-A or-B antibodies, and these patients are at higher risk of developing pulmonary arterial hypertension, but a lower risk of early interstitial lung disease, at least early in the disease course. PMID: 26455561 Source: Regenstrief LOINC , PMID: 26455561

LP157222-3   Centromere protein A
Centromere protein A (CENP-A) is an essential centromere protein encoded by the CENPA gene. Overexpression of CENP-A causes chromosomal aberrations, and depletion of CENP-A promotes apoptosis and induces cell cycle arrest. Overexpression of CENP-A has been associated with high grade cancers and is a prognostic factor for patients with estrogen receptor (ER)-positive breast cancer. Antibodies to CENP-A are associated with scleroderma, systemic sclerosis, CREST syndrome, and other rheumatologic diseases. Source: Regenstrief LOINC

Fully-Specified Name

Component
Centromere protein A Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Long Common Name
Centromere protein A Ab [Units/volume] in Serum by Line blot
Short Name
CENP A Ab Ser Line blot-aCnc
Display Name
Centromere protein A Ab Line blot Qn (S)
Consumer Name Alpha Get Info
Centromere Protein A antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both
Common Test Rank Get Info
19130

Member of these Panels

LOINC Long Common Name
88702-6 Systemic sclerosis panel - Serum by Immunoassay

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Πρωτεΐνη κεντρομερούς Α Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης
Synonyms: A ACnc Κεντρομερίδιο Πρωτεΐνη Πρωτεΐνη κεντρομερούς Α
es-ES Spanish (Spain) Proteína A del centrómero (CENP-A) Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Centrómero de proteína A Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FR French (France) Centromère protéine A anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) Centromero, proteina A Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) centromeereiwit A As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 着丝粒蛋白 A 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: A 型 A 型抗体 Ab;自身抗体 CRST 综合征;着丝粒;动粒 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 着丝点蛋白 A;centromere protein A;CENP-A;CENPA 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82390-6