82390-6
Centromere protein A Ab [Units/volume] in Serum by Line blot
Active
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Part Descriptions
LP157213-2 Centromere protein A Ab
Centromere protein A, also known as Histone H3-like centromeric protein A (CENP-A), replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. It is required for recruitment and assembly of kinetochore proteins, progression of mitosis and segregation of chromosomes. [UniProt: P49450] Anti-CENP-A antibodies are a marker of systemic sclerosis (SSc), a multisystem autoimmune connective tissue disorder that is characterized by vascular abnormalities, excessive collagen synthesis, and autoantibodies to nuclear and nucleolar proteins. Approximately 20-40% of patients with SSc are positive for anti-CENP-A or-B antibodies, and these patients are at higher risk of developing pulmonary arterial hypertension, but a lower risk of early interstitial lung disease, at least early in the disease course. PMID: 26455561
Source: Regenstrief LOINC,
PMID: 26455561
LP157222-3 Centromere protein A
Centromere protein A (CENP-A) is an essential centromere protein encoded by the CENPA gene. Overexpression of CENP-A causes chromosomal aberrations, and depletion of CENP-A promotes apoptosis and induces cell cycle arrest. Overexpression of CENP-A has been associated with high grade cancers and is a prognostic factor for patients with estrogen receptor (ER)-positive breast cancer. Antibodies to CENP-A are associated with scleroderma, systemic sclerosis, CREST syndrome, and other rheumatologic diseases.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Centromere protein A Ab:
ACnc: Pt: Ser: Qn: Line blot - Long Common Name
- Centromere protein A Ab [Units/volume] in Serum by Line blot
- Short Name
- CENP A Ab Ser Line blot-aCnc
- Display Name
- Centromere protein A Ab Line blot Qn (S)
- Consumer Name Alpha Get Info
- Centromere Protein A antibody, Blood
Part Model Get Info
- Component
- Centromere protein A Ab
LP157213-2
- Analyte
- Centromere protein A Ab
LP157213-2
- Component Numerator
- Centromere protein A Ab
LP157213-2
- Component Numerator Core
- Centromere protein A
LP157222-3
- Component Numerator Core Suffix
- Ab
LP20667-9
- Component Denominator
- NULL
- Component Denominator Core
- NULL
- Component Denominator Core Suffix
- NULL
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- ACnc
LP6773-8
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- Ser
LP7567-3
- System Core
- Ser
LP7567-3
- Super System
- NULL
- Scale
- Qn
LP7753-9
- Method
- Line blot
LP266806-1
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 19130
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 88702-6 | Systemic sclerosis Ab panel - Serum by Immunoassay |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Centromera protein A Ab: |
| el-GR | Greek (Greece) | Πρωτεΐνη κεντρομερούς Α Αντίσωμα: Synonyms: A ACnc Pt Qn SERO Αντίσωμα Γραμμή κηλίδωσης Κεντρομερίδιο Ορός Πρωτεΐνη Πρωτεΐνη κεντρομερούς Α |
| es-ES | Spanish (Spain) | Proteína A del centrómero (CENP-A) Anticuerpos: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Centrómero de proteína A Ab: |
| fr-FR | French (France) | Centromère protéine A Ac: |
| it-IT | Italian (Italy) | Centromero, proteina A Ab: Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | centromeereiwit A As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Białko centromerowe A Ab: Synonyms: CENP-A Przeciwciała do białka centromerowego A |
| zh-CN | Chinese (China) | 着丝粒蛋白 A 抗体: Synonyms: A 型 A 型抗体 Ab; |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://