LOINC
Version 2.72

85532-0Influenza virus A whole genome [Nucleotide sequence] in Isolate by SequencingActive

Term Description

The Influenza A virus genome is contained on eight RNA segments.
Segments 1-3 encode RNA polymerase subunits (segment 1 - PB2, segment 2 - PB1 and the PB1-F2 protein and segment 3 - PA).
Segment 4 encodes for hemagglutinin (HA). HA is a determinant in the severity of a viral infection.
Segment 5 encodes a nucleoprotein (NP)
Segment 6 encodes neuraminidase (NA)
Segment 7 encodes two matrix proteins (M1 and M2)
Segment 8 encodes two distinct non-structural proteins (NS1 and NEP)
Segments that encode multiple proteins due so by using different reading frames from the same RNA segment.
[PMID: 19230160The result of this test is the raw amino acid sequence of the virus.
Source: Regenstrief LOINC

Part Descriptions

LP248016-0   Influenza virus A whole genome
The influenza A and B virus genomes comprise eight segmented viral RNAs (vRNAs). Each RNA segment encodes 1 or 2 nonstructural proteins. Segmentation of the vRNAs allows viruses to exchange vRNAs with other strains. Although research has shown consistency of the packaging mechanism between viruses, it is more variable than previously thought which is relevant in understanding how infectious and noninfectious virions coordinate to produce infection. [PMID:27601575] Source: Regenstrief LOINC

LP150045-5   Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977.[PMID:271968] Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost.[PMID:18576944] Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template.[PMID:20858600] Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A whole genome
Property
Seq
Time
Pt
System
Isolate
Scale
Nom
Method
Sequencing

Additional Names

Short Name
FLUAV whole genome Islt-Seq
Display Name
FLUAV whole genome sequence Nom (Isol)
Consumer Name Alpha
Influenza A Whole Genome

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.61
Order vs. Observation
Observation

Member of these Groups

LG32757-3 Influenza virus

Language Variants Get Info

zh-CNChinese (China)
流感病毒 A 型全基因组:序列:时间点:分离株:名义型:序列测定
nl-NLDutch (Netherlands)
Influenzavirus A volledig genoom:nucleotidevolgorde:moment:isolaat:nominaal:sequencing
fr-FRFrench (France)
Influenza virus A génome complet:Séquence nucléotidique:Ponctuel:Isolat:Résultat nominal:Séquençage
it-ITItalian (Italy)
Influenza virus A, intero genoma:Seq:Pt:Isolato:Nom:Sequenziamento
es-MXSpanish (Mexico)
Virus de la influenza Un genoma completo:Secuencia de nucleótidos:Punto temporal:Aislado:Nominal:Secuenciación
es-ESSpanish (Spain)
genoma completo virus Influenza A:Secuencia de nucleótidos:Punto temporal:Aislado:Nom:Secuenciación

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85532-0