85788-8

Carbapenem resistance blaKPC gene [Presence] by NAA with non-probe detection in Positive blood culture

Discouraged

Status Information

Status: DISCOURAGED
Comment: Recommend using the term with System Isolate/Specimen and Method Molgen that aligns with the new LOINC model for molecular resistance testing that was approved by Laboratory LOINC Committee in June 2018

Map-To	Long Common Name	Mapping Guidance
49617-4	Carbapenem resistance blaKPC gene [Presence] by Molecular method

Term Description

Qualitative detection of the nucleic acid sequences in the bacterial carbapenemase resistance blaKPC gene in positive blood culture specimens by target amplification and non-probe detection methods, such as melt curve analysis. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Blood Culture Identification panel v2.

Part Descriptions

LP64707-0 Bacterial carbapenem resistance blaKPC gene
Non-susceptibility to carbapenems in gram-negative bacilli by means of the enzyme KPC (Klebsiella pneumoniae carbapenemase) is becoming more common. The gene beta-lactamase KPC (bla(KPC)) encodes KPC enzyme production, which in turn hydrolyzes and inactivates carbapenem antibiotics. KPC enzymes are a class A beta lactamases with several variants (KPC-2, KPC-3, etc) known. Various methods are used to detect specific portions of genes encoding KPC production. Carbapenemases can also be detected by other methods, including the modified Hodge test to detect carbapenemase production in isolates and minimum inhibitory concentration (MIC) to determine level of resistance. Source: Regenstrief LOINC

LP265773-4 Bacterial ABXBACT probe.amp.tar
PCR-based Methods for bacterial susceptibility are similar to genotyping for viral susceptibility, in that resistance or susceptibility is inferred based on the presence or absence of specific genetic information that is known to encode resistance to a specific antibiotic or group of antibiotics. For bacteria, resistance is often conferred by genes that are carried on plasmids, which can be transferred from one species to another. These genes encode proteins that specifically inhibit certain antibiotics, such as carbapenems or aminoglycosides. Source: Regenstrief LOINC

LP265774-2 Bacterial ABXBACT non-probe.amp.tar
PCR-based Methods for bacterial susceptibility are similar to genotyping for viral susceptibility, in that resistance or susceptibility is inferred based on the presence or absence of specific genetic information that is known to encode resistance to a specific antibiotic or group of antibiotics. For bacteria, resistance is often conferred by genes that are carried on plasmids, which can be transferred from one species to another. These genes encode proteins that specifically inhibit certain antibiotics, such as carbapenems or aminoglycosides. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Bacterial carbapenem resistance blaKPC gene:PrThr:Pt:Bld.pos growth:Ord:Non-probe.amp.tar
Long Common Name: Carbapenem resistance blaKPC gene [Presence] by NAA with non-probe detection in Positive blood culture
Short Name: blaKPC Bld Pos Ql NAA+n-prb
Display Name: Carbapenem resistance blaKPC gene NAA+non-probe Ql (Pos bld culture)
Consumer Name Alpha Get Info: Carbapenem resistance blaKPC gene, Infected blood

Part Model Get Info

Component
Bacterial carbapenem resistance blaKPC gene
LP64707-0
- Analyte
  Bacterial carbapenem resistance blaKPC gene
  LP64707-0
  - Component Numerator
    Bacterial carbapenem resistance blaKPC gene
    LP64707-0
    - Component Numerator Core
      Bacterial carbapenem resistance blaKPC gene
      LP64707-0
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld.pos growth
LP183539-8
- System Core
  Bld.pos growth
  LP183539-8
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Non-probe.amp.tar
LP208998-7

Example Answer List: LL4046-0

Source: BioFire Diagnostics LLC

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8
N/A			LA4543-0

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.82 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Gen blaKPC bakteriální rezistence na karbapenemy:Přítomnost nebo práh:Časový bod:Krev pozitivní kultivace:Ordinální:Amplifikace nukleových kyselin s detekcí bez sondy
de-DE	German (Germany)	Bakterielle Carbapenem-Resistenz blaKPC-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Blut.positives Wachstum:Ordinal:Zielfragmentamplifikation mit Detektion ohne Sonde
el-GR	Greek (Greece)	Γονίδιο blaKPC βακτηριακής ανθεκτικότητας στις καρβαπενέμες:PrThr:Pt:Αίμα.θετική ανάπτυξη:Ord:Χωρίς ανιχνευτή.ενίσχυση.στόχου Synonyms: ABXBACT Ord PrThr Pt Αίμα Αίμα.θετική ανάπτυξη Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Γονίδιο Γονίδιο blaKPC βακτηριακής ανθεκτικότητας στις καρβαπενέμες Καρβαπενέμη Χωρίς ανιχνευτή.ενίσχυση.στόχου
es-ES	Spanish (Spain)	Gen bla(KPC):PrThr:Punto temporal:Sangre crecimiento positivo:Ord:Amplificación del objetivo no basado en sonda
es-MX	Spanish (Mexico)	Gen blaKPC de resistencia a carbapenémicos bacterianos:Presencia o umbral:Punto temporal:Hemocultivo positivo:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-FR	French (France)	Résistance bactérienne aux carbapénèmases gène blaKPC:Présence/Seuil:Ponctuel:Hémoculture positive:Qualitatif:Non-PCR amplification de cible
it-IT	Italian (Italy)	Resistenza batterica ai carbapenemici, gene blaKPC:PrThr:Pt:Emocolture positive:Ord:Non-sonda.amp.tar Synonyms: Amplificazione target non basata su sonda Gene blaKPC di resistenza batterica ai carbapenemici Presenza o Soglia Punto nel tempo (episodio) Sangue Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Suscettibilità agli antibiotici
pl-PL	Polish (Poland)	Oporność bakterii na karbapenemy blaKPC gen:granica wykrywalności:punkt w czasie:krew.dodatni posiew:uporządkowany:bez sondy.amplifikacja.cel Synonyms: amplifikacja kwasu nukleinowego z detekcją bez użycia sondy amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy Antybiotyk karbapenemowy dodatni posiew krwi Gen blaKPC oporności bakterii na karbapenemy;Gen blaKPC warunkujący oporność bakterii na karbapenemy
zh-CN	Chinese (China)	细菌碳青霉烯类耐药 blaKPC 基因:存在情况或阈值:时间点:血液.生长阳性:序数型:非探针法.基因扩增.靶向 Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）扩增型扩增性抗力抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类抗耐性抵抗力抵抗性时刻;随机;随意;瞬间电阻碳青霉烯类;碳青霉烯类抗生素细菌性细菌的细菌碳青霉烯类（碳青霉烯类抗生素、碳青霉烯）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） blaKPC 基因;细菌碳青霉烯酶（碳青黴烯酶、碳青霉烯水解酶）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）blaKPC 基因经过扩增的耐性脱氧核糖核酸探针血;血液血液.阳性生长;血培养阳性;阳性血培养;阳性血液培养;全血.生长阳性遗传基因;遗传因子;吉恩;生物基因阻力

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.