Version 2.78

Part Description

LP249101-9   Bacterial colistin resistance mcr-1 gene
The mobilized colistin resistance genes (mcr-1 to mcr-5, and variants) are located on a plasmid within bacterial cells and affect the ability of antibiotics, including polymyxins and colistin, to bind to the bacteria. The mode of action of the antibiotics is to bind to the outer membrane of the phosphate group of lipid A lipopolysaccharide and to intercalate into the inner membrane forming pores that result in bacterial lysis. The polymyxins & colistin are the last line of defense used to treat multidrug resistant gram-negative bacteria so the emergence of the mcr genes in Enterobacteriaceae, including Klebsiella pneumoniae, is onerous and challenging to public health. PMID: 27893854 PMID: 29439754 Source: Regenstrief LOINC

Fully-Specified Name

Component
Bacterial colistin resistance mcr-1 gene
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
Colistin res mcr-1 Islt/Spm Ql
Display Name
Colistin resistance mcr-1 gene Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Colistin resistance mcr-1 gene

Example Answer List: LL956-4

Source: Regenstrief LOINC
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8
EquivocalCopyright http://snomed.info/sct ID:42425007 Equivocal (qualifier value) LA11885-3
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value) LA9663-1

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.65
Change Reason
Updated System from "XXX" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
104991-5 Bacterial resistance panel
85762-3 Blood pathogens panel by NAA with non-probe detection in Positive blood culture
93698-9 Gram negative bacterial resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Bakterielle Colistin-Resistenz mcr-1-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) gen bacteriano mcr-1 resistente a colistina:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Gen mcr-1 de resistencia a la colistina bacteriana:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR French (France) Résistance bactérienne à la colistine mcr-1 gène:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Gene mrc-1 di resistenza batterica alla colistina:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) bacteriële colistineresistentie mcr-1-gen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: bacterieel colistine resistentie mcr-1 gen isolaat/specimen molgen
zh-CN Chinese (China) 细菌粘菌素耐药 mcr-1 基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: Ⅰ I 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 受检物 多粘菌素 E;抗敌素;粘杆菌素;肠杆菌素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 细菌性 细菌的 细菌粘菌素（多粘菌素 E、抗敌素、粘杆菌素、肠杆菌素）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） mcr-1 基因 耐性 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86221-9