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Part Description

LP248780-1   Thymidine synthase activity interpretation
Thymidine synthase is the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) using the methyl donor 5,10-methylenetetrahydrofolate (CH2THF) as a cofactor. dTMP is critical for DNA repair and replication. Thymidine synthase has become the target for drugs used in the treatment of some cancers including the drug 5-fluorouracil (5-FU). The active metabolite of 5-FU combines with the nucleotide binding site of TS which prevents dUMP from being able to bind with TS. The decreased amount of dUMP leads to decreased cell replication. Studies have shown that the gene amplification of TS in the tumor cells correlate to resistance to 5-FU. http://www.nature.com/nrc/journal/v3/n5/fig_tab/nrc1074_F2.html Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Thymidine synthase activity interpretation:Imp:Pt:Bld/Tiss:Ord:
Long Common Name
Thymidine synthase activity interpretation in Blood or Tissue Qualitative
Short Name
TS act interp Bld/T-Imp
Display Name
Thymidine synthase activity interpretation Ql (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info
Thymidine synthase activity interpretation, Blood or tissue specimen

Part Model Get Info

  • Component
    Thymidine synthase activity interpretation
    LP248780-1
    • Analyte
      Thymidine synthase activity interpretation
      LP248780-1
      • Component Numerator
        Thymidine synthase activity interpretation
        LP248780-1
        • Component Numerator Core
          Thymidine synthase activity interpretation
          LP248780-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Example Answer List: LL4462-9

Source: Regenstrief LOINC
AnswerCodeScoreAnswer ID
HighLA9193-9
NormalCopyright http://snomed.info/sct ID:17621005 Normal (qualifier value)LA6626-1

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Thymidinsyntáza interpretace aktivity:Interpretace:Časový bod:Krev/tkáň:Ordinální:
el-GRGreek (Greece)Ερμηνεία δραστηριότητας της συνθάσης της θυμιδίνης:Imp:Pt:Αίμα/Ιστός:Ord:
Synonyms: Imp MOLPATH MOLPATH.PHARMG Ord Pt Αίμα Αίμα/Ιστός Δραστηριότητα Ερμηνεία Ερμηνεία δραστηριότητας της συνθάσης της θυμιδίνης Θυμιδίνη Ιστός
es-ESSpanish (Spain)Actividad timidina sintetasa, interpretación:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Ord:
es-MXSpanish (Mexico)Interpretación de la actividad de la timidina sintasa:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Ordinal:
fr-FRFrench (France)Thymidine synthase activité interprétation:Interprétation:Ponctuel:Sang/Tissu:Qualitatif:
it-ITItalian (Italy)Timidina, interpretazione dell'attività di sintesi:Imp:Pt:Sangue/Tess:Ord:
Synonyms: Farmacogenomica Impressione/interpretazione di studio Interpretazione dell''attività di sintesi della tim Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
zh-CNChinese (China)胸苷合成酶活性解释:印象:时间点:全血/组织:序数型:
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 判读;解释说明;说明;释义;阐明 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 活动 胸腺嘧啶核苷;胸腺定;胸苷;脱氧胸苷 胸苷（胸腺嘧啶脱氧核苷）合成酶（合酶）活性解释（说明） 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87410-7