87410-7
Thymidine synthase activity interpretation in Blood or Tissue Qualitative
Active
Part Description
LP248780-1 Thymidine synthase activity interpretation
Thymidine synthase is the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) using the methyl donor 5,10-methylenetetrahydrofolate (CH2THF) as a cofactor. dTMP is critical for DNA repair and replication. Thymidine synthase has become the target for drugs used in the treatment of some cancers including the drug 5-fluorouracil (5-FU). The active metabolite of 5-FU combines with the nucleotide binding site of TS which prevents dUMP from being able to bind with TS. The decreased amount of dUMP leads to decreased cell replication. Studies have shown that the gene amplification of TS in the tumor cells correlate to resistance to 5-FU. http://www.nature.com/nrc/journal/v3/n5/fig_tab/nrc1074_F2.html
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Thymidine synthase activity interpretation
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
Additional Names
- Short Name
- TS act interp Bld/T-Imp
- Display Name
- Thymidine synthase activity interpretation Ql (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- Thymidine synthase activity interpretation, Blood or tissue specimen
Example Answer List: LL4462-9
Source: Regenstrief LOINC| Answer | Code | Score | Answer ID |
|---|---|---|---|
| High | LA9193-9 | ||
| NormalCopyright http://snomed.info/sct ID:17621005 Normal (qualifier value) | LA6626-1 |
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.63
- Last Updated
- Version 2.63
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Actividad timidina sintetasa, interpretación: |
| es-MX | Spanish (Mexico) | Interpretación de la actividad de la timidina sintasa: |
| fr-FR | French (France) | Thymidine synthase activité interprétation: |
| it-IT | Italian (Italy) | Timidina, interpretazione dell'attività di sintesi: Synonyms: Farmacogenomica Impressione/interpretazione di studio Interpretazione dell''attività di sintesi della tim Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| zh-CN | Chinese (China) | 胸苷合成酶活性解释: Synonyms: 依次型; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=87410-7
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright