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Part Descriptions

LP150045-5   Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LP263474-1   Rotavirus A VP4 gene
Rotaviruses are non-enveloped, multilayered, icosahedral viruses composed of an outer layer, an inner layer, and a core. After the immature, double-layered virus is assembled in the host cell cytoplasm, they bud across the endoplasmic reticulum (ER) and acquire a temporary membrane that has on its surface the ER resident viral glycoproteins NSP4, VP4 and VP7. The virus loses its temporary membrane and the NSP4 glycoprotein as it moves toward the center of the ER cisternae. The VP4 and VP7 proteins are pushed to the outermost membrane layer and become the mature triple-layered rotavirus. The outer capsid glycoprotein VP7 is believed to be important for the attachment to and entry in the host cell. After it enters the host cell, the VP7 glycoprotein is lost. [UniProt: Q89865]When the host cell lyses, the mature virus are released. There are groups of rotavirus, A through H. Groups A, B, C, and H are associated with an acute gastroenteritis and are found in humans and animals. Groups D, E, F, and G are found only in animals. Rotavirus A (RVA) cause an acute gastroenteritis in children and animals. RVA is the most common infectious organism to cause severe gastroenteritis in children less than 3 years of age. It is estimated that 95% of children between the ages of 3 and 5 will become infected with RVA. Approximately 8000 children under 5 years of age in Latin America and the Caribbean die of acute enteritis caused by RVA. PMID: 2556635http://www.sciencedirect.com/science/article/pii/S004268220700400X?via%3Dihub PMID: 27462899The four serotypes of rotavirus that infect swine include A, B, C and E.https://vetmed.iastate.edu/vdpam/FSVD/swine/index-diseases/rotaviral-enteritis Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Rotavirus A VP4 gene:Seq:Pt:Isolate:Nom:Sequencing
Long Common Name
Rotavirus A VP4 gene [Nucleotide sequence] in Isolate by Sequencing
Short Name
RVA VP4 Islt-Seq
Display Name
Rotavirus A VP4 gene sequence Nom (Isol)
Consumer Name Alpha Get Info
Rotavirus A VP4 gene

Part Model Get Info

  • Component
    Rotavirus A VP4 gene
    LP263474-1
    • Analyte
      Rotavirus A VP4 gene
      LP263474-1
      • Component Numerator
        Rotavirus A VP4 gene
        LP263474-1
        • Component Numerator Core
          Rotavirus A VP4 gene
          LP263474-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Seq
    LP62164-6
  • Time
    Pt
    LP6960-1
  • System
    Isolate
    LP7370-2
    • System Core
      Isolate
      LP7370-2
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Sequencing
    LP150045-5

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.64 (MIN)
Change Reason
Abbreviated "Rotavirus A" to "RVA" in the Shortname for consistency across terms.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Rotavirus A gen VP4:Nukleotidová sekvence:Časový bod:Izolát:Nominální:Sekvenace
de-DEGerman (Germany)Rotavirus A VP4-Gen:Sequenz:Zeitpunkt:Isolat:Nominal:Sequenzierung
el-GRGreek (Greece)Γονίδιο ροταϊού A VP4:Seq:Pt:Απομονωμένο στέλεχος:Nom:Αλληλούχιση
Synonyms: A MICRO Nom Pt Seq Αλληλούχιση Απομονωμένο στέλεχος Γονίδιο Γονίδιο ροταϊού A VP4 Ροταϊός Ροταϊός Α
es-ESSpanish (Spain)Gen VP4 rotavirus A:Secuencia de nucleótidos:Punto temporal:Aislado:Nom:Secuenciación
es-MXSpanish (Mexico)Gen VP4 del rotavirus A:Secuencia de nucleótidos:Punto temporal:Aislado:Nominal:Secuenciación
fr-FRFrench (France)Rotavirus A gène VP4:Séquence nucléotidique:Ponctuel:Isolat:Résultat nominal:Séquençage
it-ITItalian (Italy)Rotavirus A, gene VP4:Seq:Pt:Isolato:Nom:Sequenziamento
Synonyms: Microbiologia Punto nel tempo (episodio) Sequenza nucleotidica
nl-NLDutch (Netherlands)Rotavirus A VP4-gen:nucleotidevolgorde:moment:isolaat:nominaal:sequencing
pl-PLPolish (Poland)Rotawirus A gen VP4:sekwencja nukleotydów:punkt w czasie:izolat:skala nominalna:sekwencjonowanie
Synonyms: GenVP4 Rootawirusa A wynik kategorialny
zh-CNChinese (China)轮状病毒 A VP4 基因:序列:时间点:分离株:名义型:序列测定
Synonyms: A 型 ROTAV;RV 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 序列分析;测序 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 核苷酸序列 轮状病毒（ROTAV、RV） A VP4 基因 轮状病毒（ROTAV、RV） A 组;A 组轮状病毒 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87713-4