Version 2.78

Part Description

LP14853-3   Varicella zoster virus
Varicella zoster virus (VZV) is a double-stranded alphaherpesvirus that causes seasonal outbreaks of chickenpox and shingles in non-immunized populations. VZV is highly infectious and is transmitted by contact with the ruptured fluid filled blisters and respiratory secretions of infected individuals. Immunity post infection is usually lifelong though the latent virus inhabits the sensory nerve ganglia where it can reactivate causing shingles when immunity declines with aging.[http://jvi.asm.org/content/88/24/13936.full] In the over fifty strains of VZV that have been sequenced it has been found that a single nucleotide polymorphism occurs about every 100 bases. The patterns of polymorphisms in VZV correlate with different geographical regions of infection and is the basis for the classification of viral clades.[https://grose.lab.uiowa.edu/vzv-genomes-and-evolution] Breuer proposed the nomenclature for the VZV clades as 1-5 with the suspected clades VI and VII to be confirmed later. The geographical regions associated with the seven clades are as follows:
Clades 1 and 3-represent the dominant clades of the circulating VZV in Europe and the Americas
Clades 4 and 5-found in Africa
Clade VI found in France, Italy
Clade VII exclusively isolated in the US
Clade 2-Asia from Korea, Japan, China not found in India, Nepal and Bangladesh where clades 4 and 5 were dominant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054591/ Source: Regenstrief LOINC

Fully-Specified Name

Component
Varicella zoster virus DNA
Property
PrThr
Time
Pt
System
Respiratory system specimen.lower
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
VZV DNA Lower resp Ql NAA+probe
Display Name
VZV DNA NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info
Varicella zoster virus (VZV; Chickenpox), Lower respiratory

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.77
Change Reason
Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
94393-6 Respiratory pathogens DNA and RNA panel - Lower respiratory specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG32750-8 Varicella zoster virus
LG50851-1 Varicella zoster virus DNA|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Varicella-Zoster-Virus DNA:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.unterer:Ordinal:Zielfragmentamplifikation mit Sondendetektion
Synonyms: Human alphaherpesvirus 3; VZV
es-MX Spanish (Mexico) ADN del virus de la varicela zóster:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ES Spanish (Spain) Virus Varicella zoster ADN:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Sonda con amplificación dirigida
Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
fr-FR French (France) Varicelle zona virus ADN:Présence/Seuil:Ponctuel:Voies respiratoires inférieures:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Varicella zoster, virus DNA:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Sonda.amp.tar
Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus della varicella zoster
nl-NL Dutch (Netherlands) varicella-zostervirus DNA:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie
Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel Varicella zoster virus

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88565-7