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Part Description

LP16650-1   Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Histoplasma capsulatum DNA:PrThr:Pt:Tiss:Ord:Probe.amp.tar
Long Common Name
Histoplasma capsulatum DNA [Presence] in Tissue by NAA with probe detection
Short Name
H capsul DNA Tiss Ql NAA+probe
Display Name
H. capsulatum DNA NAA+probe Ql (Tiss)
Consumer Name Alpha Get Info
Histoplasma capsulatum, Tissue

Part Model Get Info

  • Component
    Histoplasma capsulatum DNA
    LP38410-4
    • Analyte
      Histoplasma capsulatum DNA
      LP38410-4
      • Component Numerator
        Histoplasma capsulatum DNA
        LP38410-4
        • Component Numerator Core
          Histoplasma capsulatum
          LP16650-1
        • Component Numerator Core Suffix
          DNA
          LP32416-7
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Probe.amp.tar
    LP6464-4

Example Answer List: LL744-4

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
DetectedLA11882-0
Not detectedLA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64 (ADD)
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
95918-9Fungal pathogens panel - Tissue by NAA with probe detection

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Histoplasma capsulatum DNA:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
el-GRGreek (Greece)Histoplasma capsulatum (Ιστόπλασμα) DNA:PrThr:Pt:Ιστός:Ord:Ανιχνευτής.ενίσχυση.στόχου
Synonyms: DNA Histoplasma capsulatum (Ιστόπλασμα) MICRO Ord PrThr Pt Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Ιστός
es-ESSpanish (Spain)Histoplasma capsulatum ADN:PrThr:Punto temporal:Tejido:Ord:Sonda con amplificación dirigida
es-MXSpanish (Mexico)ADN de Histoplasma capsulatum:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-CAFrench (Canada)Histoplasma capsulatum, ADN:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Sonde avec amplification de la cible
fr-BEFrench (Belgium)Histoplasma capsulatum ADN:PrThr:Temps ponctuel:Tissu:Ordinal:Sonde avec amplification de la cible
fr-FRFrench (France)Histoplasma capsulatum ADN:Présence/Seuil:Ponctuel:Tissu:Qualitatif:PCR amplification de cible
it-ITItalian (Italy)Histoplasma capsulatum DNA:PrThr:Pt:Tessuto:Ord:Sonda.amp.tar
Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Tessuto & Strisci
nl-NLDutch (Netherlands)Histoplasma capsulatum DNA:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:probe-detectie
Synonyms: probe.amp.tar
ru-RURussian (Russian Federation)Histoplasma capsulatum ДНК:PrThr:ТчкВрм:Тк:Пор:Проба.усил.миш
Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Ткань и мазки Точка во времени;Момент
tr-TRTurkish (Turkey)Histoplazma Kapsulatum DNA:MevcEşik:Zmlı:Doku:Srl:Prob.amf.hdf
Synonyms: Mevcut
zh-CNChinese (China)荚膜组织胞浆菌 DNA:存在情况或阈值:时间点:组织与涂片:序数型:探针法.基因扩增.靶向
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 皮疽组织胞浆菌 DNA 皮疽组织胞浆菌;美洲型组织胞浆菌;鼻疽性组织浆菌 组织胞浆菌属 组织胞浆菌病 经过扩增的 美洲型组织胞浆菌 DNA 脱氧核糖核酸探针 鼻疽性组织浆菌 DNA

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88926-1