Version 2.78

Status Information

Status
TRIAL

Part Description

LP267160-2   Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
MTB rpoB RIF resist mut Islt/Spm Ql
Display Name
M. tuberculosis complex rpoB gene rifAMPin resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
7128

Member of these Panels

LOINC Long Common Name
89371-9 MTB complex DNA and rpoB RIF resistance mutation panel [Presence]
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicin-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mycobacterium tuberculosis complex rpoB gen mutación de resistencia a rifAMPin:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR French (France) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
fr-CA French (Canada) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
Synonyms: #REF!
it-IT Italian (Italy) Mycobacterium tuberculosis complex, gene rpoB rifampina resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Complesso di micobatteri della tubercolosi Gene rpoB di complesso di micobatteri della tuberc Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB RIF;甲哌力复霉素 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 受检物 复合体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌复合菌群（复合群、复合菌、复合体、复合物）;结核分支杆菌复合体;结核分支杆菌复合群;结核分支杆菌复合菌群;结核分枝杆菌复合体;结核分枝杆菌复合物;结核分枝杆菌结核菌群;结核杆菌复合菌群 结核分枝杆菌复合菌群（结核分支杆菌复合体、结核分支杆菌复合群、结核分支杆菌复合菌群、结核分枝杆菌复合体、结核分枝杆菌复合物、结核分枝杆菌结核菌群、结核杆菌复合菌群）基因利福平（甲哌力复霉素、利福霉素、立复霉素、立放平）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89372-7