89372-7

Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation [Presence] by Molecular method

Trial

Status Information

Status: TRIAL

Part Description

LP267160-2 Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation:PrThr:Pt:Isolate/Specimen:Ord:Molgen
Long Common Name: Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation [Presence] by Molecular method
Short Name: MTB rpoB RIF resist mut Islt/Spm Ql
Display Name: M. tuberculosis complex rpoB gene rifAMPin resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation

Part Model Get Info

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
LP267160-2
- Analyte
  Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
  LP267160-2
  - Component Numerator
    Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
    LP267160-2
    - Component Numerator Core
      Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
      LP267160-2
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Isolate/Specimen
LP266970-5
- System Core
  Isolate/Specimen
  LP266970-5
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Molgen
LP6404-0

Example Answer List: LL744-4

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 7128

Member of these Panels

LOINC	Long Common Name
89371-9	MTB complex DNA and rpoB RIF resistance mutation panel [Presence]
89876-7	MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Mycobacterium tuberculosis complex gen rpoB rezistence na rifampicin mutace:Přítomnost nebo práh:Časový bod:Izolát/vzorek:Ordinální:Molekulární genetika
de-DE	German (Germany)	Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicin-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
el-GR	Greek (Greece)	Μετάλλαξη ανθεκτικότητας του γονιδίου rpoB του συμπλέγματος του Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) στη ριφαμπικίνη:PrThr:Pt:Απομονωθέν στέλεχος/Δείγμα:Ord:Μοριακή γενετική Synonyms: ABXBACT Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Ord PrThr Pt Απομονωθέν στέλεχος/Δείγμα Απομονωμένο στέλεχος Γονίδιο Δείγμα Μετάλλαξη ανθεκτικότητας του γονιδίου rpoB του συμπλέγματος του Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) στη ριφαμπικίνη Μοριακή γενετική Ριφαμπικίνη Σύμπλεγμα Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης)
es-ES	Spanish (Spain)	Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis complex rpoB gen mutación de resistencia a rifAMPin:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR	French (France)	Mycobacterium complexe tuberculosis mutation du gène de résistance à la rifampicine rpoB:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
fr-CA	French (Canada)	Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
it-IT	Italian (Italy)	Mycobacterium tuberculosis complex, gene rpoB rifampina resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen Synonyms: Complesso di micobatteri della tubercolosi Gene rpoB di complesso di micobatteri della tuberc Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek Synonyms: isolaat/specimen molgen
pl-PL	Polish (Poland)	Mycobacterium tuberculosis kompleks rpoB gen oporności na ryfampicynę:granica wykrywalności:punkt w czasie:szczep/izolat lub próbka:uporządkowany:genetyka molekularna Synonyms: diagnostyka molekularna Gen rpoB warunkujący oporność Mycobacterium tuberculosis complex na ryfampicynę Prątek gruźlicy
zh-CN	Chinese (China)	结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法 Synonyms: AFB RIF;甲哌力复霉素供检查用的材料;待检物;待试验物;样品;样本;试料;试样依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应分支杆菌分支杆菌属分枝杆菌属分离株/标本（样本、样品、试样）分离物;分离菌;分离菌株;隔离种群劳瘵受检物复合体存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）抗力抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类抗耐性抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌抵抗力抵抗性时刻;随机;随意;瞬间样品样本电阻痨痨病结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌复合菌群（复合群、复合菌、复合体、复合物）;结核分支杆菌复合体;结核分支杆菌复合群;结核分支杆菌复合菌群;结核分枝杆菌复合体;结核分枝杆菌复合物;结核分枝杆菌结核菌群;结核杆菌复合菌群结核分枝杆菌复合菌群（结核分支杆菌复合体、结核分支杆菌复合群、结核分支杆菌复合菌群、结核分枝杆菌复合体、结核分枝杆菌复合物、结核分枝杆菌结核菌群、结核杆菌复合菌群）基因利福平（甲哌力复霉素、利福霉素、立复霉素、立放平）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变结核病耐性肺结核试样遗传基因;遗传因子;吉恩;生物基因阻力

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.