89516-9

Ganglioside GT1b IgG+IgM Ab [Presence] in Serum by Line blot

Active

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.

Part Descriptions

LP99341-7   Ganglioside GT1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name

Ganglioside GT1b Ab.IgG+IgM:PrThr:Pt:Ser:Ord:Line blot

Long Common Name

Ganglioside GT1b IgG+IgM Ab [Presence] in Serum by Line blot

Short Name

GT1b Ganlg IgG+IgM Ser Ql Line blot

Display Name

Ganglioside GT1b IgG+IgM Line blot Ql (S)

Consumer Name Alpha Get Info

Ganglioside GT1b IgG+IgM, Blood

Part Model Get Info

• Component

  Ganglioside GT1b Ab.IgG+IgM
  LP228513-0

  • Analyte

    Ganglioside GT1b Ab.IgG+IgM
    LP228513-0

    • Component Numerator

      Ganglioside GT1b Ab.IgG+IgM
      LP228513-0

      • Component Numerator Core

        Ganglioside GT1b
        LP99341-7

      • Component Numerator Core Suffix

        Ab.IgG+IgM
        LP32404-3

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  PrThr
  LP217195-9

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Ser
  LP7567-3

  • System Core

    Ser
    LP7567-3

  • Super System

    NULL
     

• Scale

  Ord
  LP7751-3

• Method

  Line blot
  LP266806-1

Example Answer List: LL744-4

Basic Attributes

Class

SERO

Type

Laboratory

First Released

Version 2.64

Last Updated

Version 2.64 (ADD)

Order vs. Observation

Both

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• GT1b Ganlg
• Immune globulin G
• Immune globulin M
• Immunoglobulin G
• Immunoglobulin M
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Serology
• Serum
• SR
• Trisialoganglioside

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89516-9

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.