89528-4
Nucleosome Ab [Presence] in Cerebral spinal fluid by Line blot
Active
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC
Part Description
LP31804-5 Nucleosome
The nucleosome is the structural unit of chromatin and consists of a segment of dsDNA coiled around a histone core. Anti-chromatin autoantibodies, such as those found in patients with systemic lupus erythematosus (SLE) fall in to two categories: those directed against individual components of chromatin, such as DNA and histone, and those directed against the intact nucleosome. Traditionally anti-dsDNA antibodies have been among the ones used for diagnosis and monitoring of SLE, however, studies have shown that for some patients, the nucleosome is the primary antigen in SLE, and anti-nucleosome antibodies may provide a better reflection of disease activity. A subset of patients who are positive for anti-nucleosome antibodies but negative for anti-dsDNA antibodies may have a milder course of SLE that does not involve the kidneys. PMID: 25193804
Source: Regenstrief LOINC, PMID: 25193804
Fully-Specified Name
- Component
- Nucleosome Ab
- Property
- PrThr
- Time
- Pt
- System
- CSF
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- Nucleosome Ab CSF Ql Line blot
- Display Name
- Nucleosome Ab Line blot Ql (CSF)
- Consumer Name Alpha Get Info
- Nucleosome antibody, Spinal fluid
Example Answer List: LL744-4
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG26742-3 | Nucleosome Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Nucleosoma Anticuerpos: |
| es-MX | Spanish (Mexico) | Ab nucleosoma: |
| fr-FR | French (France) | Nucléosomes anticorps: |
| fr-CA | French (Canada) | Nucléosome, Ac: |
| it-IT | Italian (Italy) | Nucleosoma Ab: Synonyms: anticorpo Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | nucleosoom As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Nukleosom Ab: Synonyms: Przeciwciała do nukleosomów |
| zh-CN | Chinese (China) | 核小体 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=89528-4
LOINC Copyright
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