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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.

Part Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

LOINC Names Get Info

Fully-Specified Name
SCL-70 extractable nuclear Ab:PrThr:Pt:CSF:Ord:Line blot
Long Common Name
SCL-70 extractable nuclear Ab [Presence] in Cerebrospinal Fluid by Line blot
Short Name
ENA Scl70 Ab CSF Ql Line blot
Display Name
SCL-70 extractable nuclear Ab Line blot Ql (CSF)
Consumer Name Alpha Get Info
SCL-70 extractable nuclear antibody, Spinal fluid

Part Model Get Info

  • Component
    SCL-70 extractable nuclear Ab
    LP39721-3
    • Analyte
      SCL-70 extractable nuclear Ab
      LP39721-3
      • Component Numerator
        SCL-70 extractable nuclear Ab
        LP39721-3
        • Component Numerator Core
          SCL-70 extractable nuclear
          LP16758-2
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL744-4

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
DetectedLA11882-0
Not detectedLA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG26773-8SCL-70 extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Antinukleární protilátky SCL-70 extrahovatelné:Přítomnost nebo práh:Časový bod:Mozkomíšní mok:Ordinální:Line blot
el-GRGreek (Greece)Εκχυλίσιμα πυρηνικά SCL-70 Αντίσωμα:PrThr:Pt:ΕΝΥ:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt SERO Αντίσωμα Γραμμή κηλίδωσης Εκχυλίσιμα πυρηνικά Εκχυλίσιμα πυρηνικά SCL-70 ΕΝΥ Πυρηνικό
es-ESSpanish (Spain)Antígeno nuclear extraíble SCL-70 Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot
es-MXSpanish (Mexico)Ab nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
fr-FRFrench (France)SCL-70 Ac:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
fr-CAFrench (Canada)SCL-70 nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
it-ITItalian (Italy)Nucleare estraibile SCL-70 Ab:PrThr:Pt:LCS:Ord:Line blot
Synonyms: anticorpo ENA Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)SCL-70 extraheerbare nucleaire As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)SCL-70 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:płyn mózgowo-rdzeniowy:uporządkowany:line blot
Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
zh-CNChinese (China)SCL-70 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
Synonyms: Ab;自身抗体 ANA CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 皮硬化症 硬皮病 硬皮病（Scleroderma，SCL） 硬皮症 线点杂交技术;线点杂交法;线条状印迹法 细胞核 Ab 胞核 Ab 胞核抗体 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89533-4