89542-5
Centromere protein B Ab [Presence] in Cerebral spinal fluid by Line blot
Active
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Part Description
LP71684-2 Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. PMID: 25942623 Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. PMID: 17210244
Source: Regenstrief LOINC
, UniProt: P07199
Fully-Specified Name
- Component
- Centromere protein B Ab
- Property
- PrThr
- Time
- Pt
- System
- CSF
- Scale
- Ord
- Method
- Line blot
Additional Names
- Long Common Name
- Centromere protein B Ab [Presence] in Cerebral spinal fluid by Line blot
- Short Name
- Centromere B Ab CSF Ql Line blot
- Display Name
- Centromere protein B Ab Line blot Ql (CSF)
- Consumer Name Alpha Get Info
- Centromere Protein B antibody, Spinal fluid
Example Answer List: LL744-4
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
Detected | LA11882-0 | ||
Not detected | LA11883-8 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64 (ADD)
- Order vs. Observation
- Both
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG29561-4 | Centromere protein B Ab| |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Πρωτεΐνη κεντρομερούς Β Αντίσωμα: Synonyms: B PrThr Κεντρομερίδιο Πρωτεΐνη Πρωτεΐνη κεντρομερούς Β |
es-ES | Spanish (Spain) | Proteína B del centrómero Anticuerpos: |
es-MX | Spanish (Mexico) | Centrómero de proteína B Ab: |
fr-FR | French (France) | Centromère protéine B anticorps: |
fr-CA | French (Canada) | Centromère protéine B, Ac: |
it-IT | Italian (Italy) | Centromero, proteina B Ab: Synonyms: anticorpo Liquido cerebrospinale Presenza o Soglia Proteina B del centromero Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant |
nl-NL | Dutch (Netherlands) | centromeereiwit B As: Synonyms: antistof; |
zh-CN | Chinese (China) | 着丝点蛋白 B 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=89542-5
LOINC Copyright
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