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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.

Part Description

LP71684-2   Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. PMID: 25942623 Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. PMID: 17210244 Source: Regenstrief LOINC, UniProt: P07199

LOINC Names Get Info

Fully-Specified Name
Centromere protein B Ab:PrThr:Pt:CSF:Ord:Line blot
Long Common Name
Centromere protein B Ab [Presence] in Cerebrospinal Fluid by Line blot
Short Name
Centromere B Ab CSF Ql Line blot
Display Name
Centromere protein B Ab Line blot Ql (CSF)
Consumer Name Alpha Get Info
Centromere Protein B antibody, Spinal fluid

Part Model Get Info

  • Component
    Centromere protein B Ab
    LP71684-2
    • Analyte
      Centromere protein B Ab
      LP71684-2
      • Component Numerator
        Centromere protein B Ab
        LP71684-2
        • Component Numerator Core
          Centromere protein B
          LP71685-9
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL744-4

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
DetectedLA11882-0
Not detectedLA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG29561-4Centromere protein B Ab|PrThr|Pt|CSF

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Centromera protein B Ab:Přítomnost nebo práh:Časový bod:Mozkomíšní mok:Ordinální:Line blot
el-GRGreek (Greece)Πρωτεΐνη κεντρομερούς Β Αντίσωμα:PrThr:Pt:ΕΝΥ:Ord:Γραμμή κηλίδωσης
Synonyms: B Ord PrThr Pt SERO Αντίσωμα Γραμμή κηλίδωσης ΕΝΥ Κεντρομερίδιο Πρωτεΐνη Πρωτεΐνη κεντρομερούς Β
es-ESSpanish (Spain)Proteína B del centrómero Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot
es-MXSpanish (Mexico)Centrómero de proteína B Ab:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
fr-FRFrench (France)Centromère protéine B Ac:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
fr-CAFrench (Canada)Centromère protéine B, Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
it-ITItalian (Italy)Centromero, proteina B Ab:PrThr:Pt:LCS:Ord:Line blot
Synonyms: anticorpo Liquido cerebrospinale Presenza o Soglia Proteina B del centromero Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)centromeereiwit B As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Białko centromerowe B Ab:granica wykrywalności:punkt w czasie:płyn mózgowo-rdzeniowy:uporządkowany:line blot
Synonyms: CENP-B Przeciwciała do antygenu B Przeciwciała do centromerowego białka F
zh-CNChinese (China)着丝点蛋白 B 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
Synonyms: Ab;自身抗体 B 型 B型抗体 CRST 综合征;着丝粒;动粒 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 着丝粒蛋白 B;动粒蛋白 B 线点杂交技术;线点杂交法;线条状印迹法 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89542-5