Version 2.78

Part Descriptions

LP19492-5   Thiopurine methyltransferase
Thiopurine methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs including 6-mercatptopurine, thioguanine, and azathioprine (AZA). These drugs are used to treat acute lymphoblastic leukemia, inflammatory bowel disease, rheumatoid arthritis, and organ transplant rejection. Patients with low or absent TPMT activity are at increased risk for toxicity due to increased accumulation of unmetabolised drug. Information from Current Clinical Pharmacology. 2006;1:119-128. Source: Regenstrief Institute

LP270162-3   Production of 6-Methylmercaptopurine
6-Methylmercaptopurine (6MMP) is a metabolite of thiopurine drugs including including 6-mercatptopurine, thioguanine, and azathioprine. Levels of 6-methylthioguanine are indicative of thiopurine S-methyltransferase (TPMT) activity. PMID: 23962279 Source: Regenstrief LOINC

Fully-Specified Name

Component
Thiopurine methyltransferase
Property
CCnc
Time
Pt
System
RBC
Scale
Qn
Method
Production of 6-Methylmercaptopurine

Additional Names

Short Name
TPMT RBC production of 6-MMP-cCnc
Display Name
Thiopurine methyltransferase production of 6-MMP (RBC) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Thiopurine methyltransferase, Red blood cells

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.65
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
91139-6 Thiopurine methyltransferase activity panel - Red Blood Cells

Member of these Groups Get Info

LOINC Group Group Name
LG50142-5 Thiopurine methyltransferase|CCnc|Pt|RBC

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Tiopurina metiltransferasa:Concentración Catalítica:Punto temporal:Glóbulos rojos:Qn:Producción de 6-metil-mercaptopurina
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Tiopurina metiltransferasa:Concentración catalítica:Punto temporal:Eritrocitos:Cuantitativo:Producción de 6-metilmercaptopurina
fr-FR French (France) Thiopurine méthyltransférase:Catalytique/Volume:Ponctuel:Érythrocytes:Numérique:Production de 6-méthylmercaptopurine
it-IT Italian (Italy) Tiopurina metiltransferasi:CCnC:Pt:RBC:Qn:Produzione di 6-Metilmercaptopurina
Synonyms: Chimica Concentrazione Catalitica Globuli rossi Punto nel tempo (episodio)
zh-CN Chinese (China) 硫嘌呤甲基转移酶:催化浓度:时间点:红细胞:定量型:6-甲基巯基嘌呤生成法
Synonyms: 6-甲基巯基嘌呤（6-甲基巯嘌呤、6-甲基-巯嘌呤、6-甲基-巯基嘌呤）生成法（产生法、产量法） RBC;RBCS;红血球;红血细胞;赤血球 TPMT;巯嘌呤甲基转移酶 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 转甲基酶

Example Units

Unit Source
nmol/mL/h Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=91141-2