93726-8
Dermatan sulfate and heparan sulfate and keratan sulfate panel - Serum or Plasma
Active
2203-8 Dermatan sulfate [Mass/volume] in Serum or Plasma
Part Descriptions
LP15532-2 Dermatan sulfate
Dermatan sulfate is a derived disaccharide that accumulates in lysosomes, extracellular matrix, and body fluids of people with mucopolysaccharidoses (MPSs). MPSs are rare disorders caused by a deficiency of enzymes that break down glycosaminoglycans (GAGs). Symptoms of MPS vary due to which storage product accumulates and the level of enzymatic function or concentration that remains. Symptoms include musculoskeletal, airway, cardiac, and central nervous system disorders. Treatments include hematopoietic stem cell transplantation for the more critical forms of MPS and intravenous enzyme replacement therapy for the others. Treatment is most effective when it is initiated before irreversible tissue damage has occurred. Because MPS is so rare and the symptoms so variable, it is difficult to diagnose in its earliest stages. A solution to that problem is the development of newborn screening assays that can detect dermatan sulfate, though the levels in the dried blood spot samples do not appear to predict the severity of disease. The pattern of dermatan and heparan sulfate can help distinguish between the different MPSs. PMID: 23084433
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Dermatan sulfate
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.34 (MIN)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 93726-8 | Dermatan sulfate and heparan sulfate and keratan sulfate panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Θειική δερματάνη: Synonyms: MCnc |
| es-AR | Spanish (Argentina) | dermatán sulfato: |
| es-ES | Spanish (Spain) | Dermatan sulfato: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sulfato de dermatán: |
| et-EE | Estonian (Estonia) | Dermataansulfaat: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | Dermatane sulfate: |
| fr-FR | French (France) | Dermatane sulfate: |
| fr-BE | French (Belgium) | Dermatane-sulfate: Synonyms: SO4 |
| it-IT | Italian (Italy) | Dermatan solfato: Synonyms: Chimica Concentrazione di Massa Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| ko-KR | Korean (Korea, Republic Of) | 더마탄 황산염: |
| nl-NL | Dutch (Netherlands) | dermatansulfaat: |
| pt-BR | Portuguese (Brazil) | Sulfato de dermatan: Synonyms: SO4-2; |
| ru-RU | Russian (Russian Federation) | Дерматан сульфат: Synonyms: Дерматансульфат Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Dermatan sülfat: |
| zh-CN | Chinese (China) | 硫酸皮肤素: Synonyms: SO4; |
93725-0 Heparan sulfate [Mass/volume] in Serum or Plasma
Part Descriptions
LP15629-6 Heparan sulfate
Heparan sulfate is a derived disaccharide that accumulates in lysosomes, extracellular matrix, and body fluids of people with mucopolysaccharidoses (MPSs). MPSs are rare disorders caused by a deficiency of enzymes that break down glycosaminoglycans (GAGs). Symptoms of MPS vary due to which storage product accumulates and the level of enzymatic function or concentration that remains. Symptoms include musculoskeletal, airway, cardiac, and central nervous system disorders. Treatments include hematopoietic stem cell transplantation for the more critical forms of MPS and intravenous enzyme replacement therapy for the others. Treatment is most effective when it is initiated before irreversible tissue damage has occurred. Because MPS is so rare and the symptoms so variable, it is difficult to diagnose in its earliest stages. A solution to that problem is the development of newborn screening assays that can detect heparan sulfate, though the levels in the dried blood spot samples do not appear to predict the severity of disease. The pattern of dermatan and heparan sulfate can help distinguish between the different MPSs. PMID: 23084433
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Heparan sulfate
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.67 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 93726-8 | Dermatan sulfate and heparan sulfate and keratan sulfate panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Θειική ηπαράνη: Synonyms: MCnc Θειικά άλατα Θειική ηπαράνη |
| es-MX | Spanish (Mexico) | Sulfato de Heparán: |
| es-ES | Spanish (Spain) | Heparán sulfato: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Heparaansulfaat: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | Héparane sulfate: |
| fr-FR | French (France) | Héparane sulfate: |
| fr-BE | French (Belgium) | Héparane-sulfate: Synonyms: SO4 |
| it-IT | Italian (Italy) | Eparan solfato: Synonyms: Chimica Concentrazione di Massa Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| nl-NL | Dutch (Netherlands) | heparansulfaat: |
| ru-RU | Russian (Russian Federation) | Гепаран сульфат: Synonyms: Гепарансульфат Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Heparan sülfat: |
| zh-CN | Chinese (China) | 硫酸类肝素: Synonyms: SO4; |
Example Units
| Unit | Source |
|---|---|
| ng/mL | Example UCUM Units |
93724-3 Keratan sulfate [Mass/volume] in Serum or Plasma
Part Descriptions
LP14490-4 Keratan sulfate
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
Source: National Library of Medicine, MeSH 2006
LP14490-4 Keratan sulfate
Keratan sulfate (KS) is one of the glycosaminoglycans found primarily in the cornea, nervous tissue, and bone. When the enzyme that breaks down KS is deficient or absent, KS accumulates in lysosomes which results in cell, tissue, and organ dysfunction. The lysosomal storage disorders are known as mucopolysaccharidoses (MPS) and can involve impaired enzymatic function that blocks the catabolism of any of the glycosaminoglycans, including dermatan sulfate, heparin sulfate, keratan sulfate, chondroitin sulfate, or hyaluronan. MPS due to the accumulation of any one or more glycosaminoglycans have many symptoms in common including a chronic or progressive course, multisystem involvement, organomegaly, dysostosis multiplex, abnormal facies, affected hearing, affected vision, affected airway, cardiovascular issues, profound mental retardation, and joint mobility difficulties. MPS can be diagnosed by testing for the deficient or absent enzyme. Enzyme replacement therapy is used to monitor treatment.[https://ommbid.mhmedical.com/content.aspx?bookid=971§ionid=62642135]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Keratan sulfate
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.67 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 93726-8 | Dermatan sulfate and heparan sulfate and keratan sulfate panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG50938-6 | Keratan sulfate| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Θειική κερατάνη: Synonyms: MCnc Θειικά άλατα Θειική κερατάνη |
| es-ES | Spanish (Spain) | Queratán sulfato: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sulfato de queratán: |
| et-EE | Estonian (Estonia) | Kerataansulfaat: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-BE | French (Belgium) | Sulfate de kératane: Synonyms: SO4 |
| fr-FR | French (France) | Kératane sulfate: |
| fr-CA | French (Canada) | Sulfate de kératane: |
| it-IT | Italian (Italy) | Cheratan solfato: Synonyms: Chimica Concentrazione di Massa Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| nl-NL | Dutch (Netherlands) | keratansulfaat: |
| ru-RU | Russian (Russian Federation) | Кератансульфат: Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Keratan sülfat: |
| zh-CN | Chinese (China) | 硫酸角质素: Synonyms: SO4; |
Example Units
| Unit | Source |
|---|---|
| ng/mL | Example UCUM Units |