Version 2.78

Part Description

LP15884-7   Tetrahydrodeoxycortisol
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. PMID: 16984984, PMID: 15522937, PMID: 15272911. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tetrahydrodeoxycortisol

Fully-Specified Name

Component
Tetrahydrodeoxycortisol
Property
Zscore
Time
24H
System
Urine
Scale
Qn
Method

Additional Names

Short Name
TH-DC 24h Z-score Ur
Display Name
Tetrahydrodeoxycortisol (24H U) [Z-score]
Consumer Name Alpha Get Info
Tetrahydrodeoxycortisol, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
95556-7 Adrenal cancer risk assessment and urine steroid fractions panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Tetrahidrodesoxicortisol:Puntuación Z:24 horas:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Tetrahidrodesoxicortisol:Puntuación Z:24H:Orina:Cuantitativo:
fr-FR French (France) Tétrahydro-11-déoxycortisol:Z score:24H:Urine:Numérique:
it-IT Italian (Italy) Tetraidrodeossicortisolo:Zscore:24h:Urine:Qn:
Synonyms: 24 Ore Chimica Z-score
nl-NL Dutch (Netherlands) tetrahydrodeoxycortisol:Z-score:24 uur:urine:kwantitatief:
Synonyms: 24U
ru-RU Russian (Russian Federation) Тетрагидродеоксикортизол:Z-тест:24 часа:Моча:Колич:
Synonyms: Z-тест Фишера Количественный Тетрагидродезоксикортизол
tr-TR Turkish (Turkey) Tetrahidrodeoksikortizol:Zskoru:24Sa:İdrar:Kant:
zh-CN Chinese (China) 四氢脱氧皮质醇:Z评分:24小时:尿液:定量型:
Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 TH-DC;四氢-11-脱氧皮质醇;四氢脱氧皮质甾醇;四氢脱氧皮醇 Z分;Z分值;Z分数;Z得分;Z-评分;Z评分（分值、得分、分数） 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉

Example Units

Unit Source
{Zscore} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95578-1