95649-0

Chikungunya virus neutralizing antibody [Titer] in Specimen by Neutralization test

Active

Part Descriptions

LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP21132-3 Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3 Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Chikungunya virus Ab.Neut:Titr:Pt:XXX:SemiQn:Neut
Long Common Name: Chikungunya virus neutralizing antibody [Titer] in Specimen by Neutralization test
Short Name: CHIKV NAb Titr Spec Nt
Display Name: CHIKV neut ab Neut test (Specimen) [Titer]
Consumer Name Alpha Get Info: Chikungunya virus neutralizing antibody, Specimen

Part Model Get Info

Component
Chikungunya virus Ab.Neut
LP430336-0
- Analyte
  Chikungunya virus Ab.Neut
  LP430336-0
  - Component Numerator
    Chikungunya virus Ab.Neut
    LP430336-0
    - Component Numerator Core
      Chikungunya virus
      LP21132-3
    - Component Numerator Core Suffix
      Ab.Neut
      LP207365-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Titr
LP6881-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
XXX
LP7735-6
- System Core
  XXX
  LP7735-6
- Super System
  NULL
Scale
SemiQn
LP436123-6
Method
Neut
LP6416-4

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.75 (MAJ)
Change Reason: Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG51028-5	Chikungunya virus

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus Chikungunya Ab.neutralizační:Arbitrární koncentrace (titr):Časový bod:XXX:Semikvantitativní:Neutralizační test
el-GR	Greek (Greece)	Ιός Chikungunya Ab.Neut:Titr:Pt:XXX:Ημιποσοτική:Ουδετερόφιλα Synonyms: Ab.Neut MICRO Pt Titr XXX Αντίσωμα Ημιποσοτική Ιός Ιός Chikungunya Ουδετερόφιλα
es-ES	Spanish (Spain)	Virus Chikungunya Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:XXX:Semicuantitativo:Prueba de neutralización Synonyms: Semicuantitativo
es-MX	Spanish (Mexico)	Virus de Chikungunya Ab:Título:Punto temporal:XXX:Cuantitativo:Prueba de neutralización
fr-FR	French (France)	Chikungunya virus Ac neutralisant:Titre:Ponctuel:Milieux divers:Semi-Quantitatif:Neutralisation
fr-CA	French (Canada)	Virus Chikungunya Ac.neut:Titre:Temps ponctuel:XXX:SemiQn:Test de neutralisation
it-IT	Italian (Italy)	Chikungunya virus Ab.Neut:Titr:Pt:XXX:SemiQn:Neut Synonyms: anticorpo CHIK Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo
nl-NL	Dutch (Netherlands)	Chikungunya-virus As.neutraliserend:titer:moment:XXX:semikwantitatief:neutralisatietest Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Wirus Chikungunya Ab.Neutralizujące:miano:punkt w czasie:XXX:półilościowy:test neutralizacji Synonyms: Przeciwciała do wirusa Chikungunya Przeciwciała neutralizujące do wirusa Chikungunya Wirus Chikungunya
zh-CN	Chinese (China)	基孔肯亚病毒抗体.中和:滴定度:时间点:XXX:半定量型:中和试验 Synonyms: Ab;自身抗体 CHIKV Ab CHIKV 抗体不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项中和试验;中和抗体;中和传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体基孔肯亚病毒 Ab 基孔肯雅病毒 Ab 基孔肯雅病毒抗体奇昆古尼亚病毒;基孔肯雅病毒;CHIKV 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数时刻;随机;随意;瞬间

Example Units

Unit	Source
{titer}	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.