Version 2.70

97965-8Dermatophagoides pteronyssinus recombinant (rDer p) 1 IgG4 Ab [Mass/volume] in SerumActive

Part Descriptions

LP265996-1   Dermatophagoides pteronyssinus recombinant (rDer p) 1
Dermatophagoides pteronyssinus is one of thirteen species of dust mites that are found in temperate climates worldwide, and is a major source of mite allergen. The three most common dust mites include Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei. Dust mites feed on skin scales and other organic debris. Their feces and bodies are the source of many of the allergens that affect humans. House dust mite allergens are divided into 13 groups that are based on their biochemical structure, sequence homology, and molecular weight. Each allergen is designated by the first three letters of the genus of house mite with which it is associated, then the first letter of the species name, and finally a number that indicates the order in which the allergen was isolated. Group 1 allergens are glycoproteins that originally lined the intestinal tract of the mite and possess cysteine protease activity. The epitope Der p 1 increases allergenicity by its ability to split both the CD23 IgE receptor found on the membrane of human B cells, and the CD25 subunit of the T-cell IL-2 receptor. [PMID: 11242601] Source: Regenstrief LOINC

LP32397-9   Ab.IgG4
IgG4 is the least common subtype of IgG, and it has a variety of functions. In the context of allergic disease it is thought to have an immune-inhibitory role in preventing anaphylaxis and is commonly known as a “blocking” antibody. IgG4 binding to an allergen can compete with IgE-mediated binding, thereby inhibiting the activation of mast cells and basophils and IgE-mediated presentation to T-cells. Measuring IgG4 and its ratio to IgE has a role in monitoring allergen specific immunotherapy [PMID: 26023323] . IgG4 is also thought to have a role in autoimmunity and be involved in a less defined entity known as IgG4-Related Disease, a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses .[https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/igg4-related-disease/igg4-related-disease] Source: Regenstrief LOINC

Fully-Specified Name

Dermatophagoides pteronyssinus recombinant (rDer p) 1 Ab.IgG4

Additional Names

Short Name
D pteronyss (rDer p) 1 IgG4-mCnc
Display Name
European house dust mite recombinant (rDer p) 1 IgG4 (S) [Mass/Vol]
Consumer Name Alpha
European house dust mite recombinant (rDer p) 1 IgG4 antibody

Basic Attributes

First Released
Version 2.70
Last Updated
Version 2.70
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
屋尘螨 重组 (rDer p) 1 抗体.IgG4:质量浓度:时间点:血清:定量型:
it-ITItalian (Italy)
Dermatophagoides pteronyssinus, ricombinante (rDer p) 1 , Ab.IgG4:MCnc:Pt:Siero:Qn:
es-ESSpanish (Spain)
Dermatophagoides farinae recombinante (rDer f) 2 IgG4:Concentración de masa:Punto temporal:Suero:Qn:

Example Units

Unit Source
mg/L Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info