94565-9 SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with non-probe detection

Term Description

Qualitative results for the detection of SARS coronavirus 2 (SARS-CoV-2) in nasopharyngeal specimens by nucleic acid amplification with non-probe based detection, such as melt curve analysis. Results may be based on multiple assays to determine the presence of the virus in a specimen. Testing is performed for the diagnosis of Coronavirus Disease 2019 (COVID-19).

Part Descriptions

LP417540-4   SARS coronavirus 2
The 2019 Novel Coronavirus (2019-nCoV) is a coronavirus first identified as the cause of a respiratory illness outbreak in Wuhan, China. Initially, the outbreak was linked to a large seafood and animal market and thought to only be spread by animal to person contact. Within a short time, a growing number of patients who had not been exposed to animal markets were diagnosed with the infection, indicating person-to-person transmission. As of January 2020, infections with 2019-nCoV had been reported internationally due to confirmed cases in travelers from Wuhan. Overall, clinical symptoms appear milder than SARS Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome (MERS) Coronavirus (MERS-CoV) infections as do the fatality rate and transmissibility. PMID: 31953166 Reported illnesses range from minor or no respiratory symptoms to severe acute respiratory illness and death.

The full genome of the 2019-nCoV was first posted by Chinese health authorities in GenBank, the NIH genetic sequence database, and in the Global Initiative on Sharing All Influenza Data (GISAI) portal. This facilitated detection of the virus globally with subsequent sequences being nearly identical, suggesting a single, recent emergence from a virus related to bat coronaviruses and the SARS coronavirus. Source: LOINC

Fully-Specified Name

Component

SARS coronavirus 2 RNA

Property

PrThr

Time

Pt

System

Nph

Scale

Ord

Method

Non-probe.amp.tar

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.68

Last Updated

Version 2.82 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

1132

Example Answer List LL3713-6

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 2019 Novel Coronavirus
• 2019-nCoV
• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• Corona virus
• COVID19
• COVID-19
• DNA NUCLEIC ACID PROBE
• DNA probe
• ID
• II
• Infectious Disease
• InfectiousDisease
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Microbiology
• NAA+n-prb
• NAA+probe
• NAAT
• NASBA
• Nasopharynx
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Ribonucleic acid
• SARS Coronavirus 1
• SARS-CoV
• SARS-CoV-1
• SARS-CoV-2
• Screen
• SDA
• Severe Acute Respiratory Syndrome
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification
• Viral Pneumonias
• Wuhan coronavirus

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82175-1 Rhinovirus+Enterovirus RNA [Presence] in Nasopharynx by NAA with non-probe detection

Term Description

Qualitative detection of nucleic acid sequences in rhinovirus and enterovirus RNA in nasopharyngeal swabs by target amplification and non-probe detection methods, such as melt curve analysis. This assay does not distinguish between the two picornaviruses. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Respiratory Panel (RP) v1.7.

Part Descriptions

LP35705-0   Rhinovirus+Enterovirus
Human rhinoviruses (HRVs) can be categorized into three genetically distinct HRV groups, designated groups A, B, and C, within the genus Enterovirus and the family Picornaviridae. HRVs are positive-sense, single-stranded-RNA (ssRNA) viruses of approximately 7,200 bp. HRVs, which are the cause of more than one-half of cold like illnesses, are commonly associated with upper respiratory tract infection, otitis media, and sinusitis. PCR testing for respiratory virus detection has led to the recognition of HRV as a lower respiratory tract pathogen as well, especially in patients with asthma, infants, elderly patients, and immunocompromised individuals. At this time there are no approved antiviral therapies, and treatment is primarily supportive. Source: Regenstrief LOINC, PMCID: PMC3553670

LP35705-0   Rhinovirus+Enterovirus
Enteroviruses are small, non-enveloped, single stranded RNA viruses in the picornavirus family and include coxsackievirus, rhinovirus, echovirus, and poliovirus species. They are the most common viral pathogen worldwide, and clinical manifestations range from mild, cold-like symptoms to severe infections, including encephalitis, aseptic (viral) meningitis, and myocarditis. Enterovirus infection has also been associated with the onset of type I diabetes mellitus. PMID: 23764548 Source: Regenstrief LOINC, PMID: 23764548

Fully-Specified Name

Component

Rhinovirus+Enterovirus RNA

Property

PrThr

Time

Pt

System

Nph

Scale

Ord

Method

Non-probe.amp.tar

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.56

Last Updated

Version 2.82 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

1672

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• DNA NUCLEIC ACID PROBE
• DNA probe
• Entero virus
• EV
• EV-PCR
• HRV
• ID
• Infectious Disease
• InfectiousDisease
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Microbiology
• NAA+n-prb
• NAA+probe
• NAAT
• NASBA
• Nasopharynx
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Rhino virus
• RHV
• Ribonucleic acid
• RV+EV
• RV+EV RNA
• Screen
• SDA
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification

82166-0 Influenza virus A RNA [Presence] in Nasopharynx by NAA with non-probe detection

Term Description

Qualitative detection of nucleic acid sequences in Influenza virus A RNA in nasopharyngeal swabs by target amplification and non-probe detection methods, such as melt curve analysis. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Respiratory Panel (RP) v1.7.

Part Descriptions

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. PMID: 20542248 ] PMID: 25812763
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component

Influenza virus A RNA

Property

PrThr

Time

Pt

System

Nph

Scale

Ord

Method

Non-probe.amp.tar

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.56

Last Updated

Version 2.82 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

1673

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• Avian influenza
• Bird flu
• DNA NUCLEIC ACID PROBE
• DNA probe
• FLUA
• FLUAV
• FLUV
• Fowl plague
• ID
• Infectious Disease
• InfectiousDisease
• Influ
• Influenza A
• Influenza A virus
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Microbiology
• NAA+n-prb
• NAA+probe
• NAAT
• NASBA
• Nasopharynx
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Ribonucleic acid
• Screen
• SDA
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification

82170-2 Influenza virus B RNA [Presence] in Nasopharynx by NAA with non-probe detection

Term Description

Qualitative detection of nucleic acid sequences in Influenza virus B RNA in nasopharyngeal swabs by target amplification and non-probe detection methods, such as melt curve analysis. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Respiratory Panel (RP) v1.7.

Part Descriptions

LP14240-3   Influenza virus B
Influenza virus from the family Orthomyxoviridae are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C viruses are medically relevant to humans. Influenza A and B viruses have a similar structure whereby these viruses each contain eight discrete single-stranded RNA gene segments, each encoding at least one protein. While having a close phylogenetic relationship, influenza virus types A and B manifest very differently. While IAV infects birds, humans and other mammals, influenza B only infects humans and seals. Although both viruses cause human respiratory infection seasonally in temperate climate regions and more continually in the tropics, influenza B is normally less prevalent and causes less severe disease than IAV viruses. Research is ongoing to determine the evolutionary and epidemiological factors that shape the genetic diversity of influenza B virus. PMID: 25812763 [CDC:flu/about/viruses/types] Source: Regenstrief LOINC

Fully-Specified Name

Component

Influenza virus B RNA

Property

PrThr

Time

Pt

System

Nph

Scale

Ord

Method

Non-probe.amp.tar

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.56

Last Updated

Version 2.82 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

1669

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• DNA NUCLEIC ACID PROBE
• DNA probe
• FLUB
• FLUBV
• FLUV
• ID
• Infectious Disease
• InfectiousDisease
• Influ
• Influenza B
• Influenza B virus
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Microbiology
• NAA+n-prb
• NAA+probe
• NAAT
• NASBA
• Nasopharynx
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Ribonucleic acid
• Screen
• SDA
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification

82176-9 Respiratory syncytial virus RNA [Presence] in Nasopharynx by NAA with non-probe detection

Term Description

Qualitative detection of nucleic acid sequences in Respiratory syncytial virus RNA in nasopharyngeal swabs by target amplification and non-probe detection methods, such as melt curve analysis. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Respiratory Panel (RP) v1.7.

Part Descriptions

LP14244-5   Respiratory syncytial virus
Human respiratory syncytial virus (RSV), a negative-sense, single-stranded RNA virus of the family Paramyxoviridae, causes upper respiratory tract infections and bronchiolitis, an infection of the small airways that can cause wheezing and respiratory distress. Infants, especially those that were born prematurely, are particularly susceptible, and RSV bronchiolitis is a common cause of hospitalization for infants during the winter months. Certain groups of high-risk infants may be given palivizumab, a recombinant monoclonal antibody to RSV, as prophylaxis against RSV infection. Source: Regenstrief LOINC

LP39551-4   Respiratory syncytial virus RNA
The respiratory syncytial virus (RSV) is a member of the Paramyxoviridae family and is an enveloped pleomorphic virus. RSV is spread through contact with respiratory droplets, contact with the patient and contact with contaminated surfaces. The rate of transmission is affected by outside temperature, humidity and precipitation. RSV infection spreads faster when the temperature is low and the humidity is high in temperate zones and when rainfall levels are high in tropical climates. RSV causes severe lower respiratory infections in infants and young children. Infants born prematurely are particularly susceptible. Symptoms of RSV infection include cough, low-grade fever and rhinorrhea. High risk adult populations including patients in residential facilities, those with heart and lung diseases and immunocompromised patients are susceptible to severe RSV infection and significant morbidity.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component

Respiratory syncytial virus RNA

Property

PrThr

Time

Pt

System

Nph

Scale

Ord

Method

Non-probe.amp.tar

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.56

Last Updated

Version 2.82 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

1638

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• DNA NUCLEIC ACID PROBE
• DNA probe
• HRSV
• ID
• Infectious Disease
• InfectiousDisease
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Lung
• Microbiology
• NAA+n-prb
• NAA+probe
• NAAT
• NASBA
• Nasopharynx
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• Pulmonary
• Pulmonology
• QBR
• QL
• Qual
• Qualitative
• Random
• Respiratory
• Ribonucleic acid
• RSV
• Screen
• SDA
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification