4548-4Hemoglobin A1c/Hemoglobin.total in BloodActive
- Component
- Hemoglobin A1c/Hemoglobin.total
- Property
- MFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Additional Names
- Short Name
- Hgb A1c MFr Bld
- Display Name Beta
- HbA1c (Bld) [Mass fraction]
- Consumer Name Alpha
- HbA1c, Blood
Part Description
LP16413-4 Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:
1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least
Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.
Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as “HPLC”, “electrophoresis” or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.
A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:
-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol – no decimals) and NGSP derived units (percentage – one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)
Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent – i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.
LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.
These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.
The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.
Source: Regenstrief Help
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.66
- Change Reason
- Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.
- Order vs. Observation
- Both
- Common US Lab Results Rank
- 81
- Common SI Lab Results Rank
- 81
- Common Orders Rank
- 48
- CDISC Lab Test
- Yes
Reference Information
| Type | Source | Reference |
|---|---|---|
| Mapping Guidance | Regenstrief Help | Today, all US HbA1c measurements reported in the US and many other countries are standardized to the NGSP protocol and that has been true for years. This code [LOINC: 4548-4] should be used for reporting the HbA1c in the US. Other countries may report HbA1c measured by the IFCC protocol [LOINC: 59261-8], a protocol with results reported in units of mmol/mol. In Japan and parts of Spain it may be measured using the Japanese protocol. All three protocols produce different numeric values. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations |
| Webcontent | Lab Tests Online®Copyright Copyright 2001-2019 American Association for Clinical Chemistry. | Hemoglobin A1c |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 52743-2 | Continuity Assessment Record and Evaluation (CARE) tool - Acute Care |
| 52748-1 | Continuity Assessment Record and Evaluation (CARE) tool - Home Health Admission |
| 52746-5 | Continuity Assessment Record and Evaluation (CARE) tool - Interim |
| 52744-0 | Continuity Assessment Record and Evaluation (CARE) tool - Post Acute Care (PAC) - Admission |
| 52745-7 | Continuity Assessment Record and Evaluation (CARE) tool - Post Acute Care (PAC) - Discharge |
| 55399-0 | Diabetes tracking panel |
| 67868-0 | End Stage Renal Disease (ESRD) Medical Evidence Report, Medicare Entitlement AndOr Patient Registration - OMB CMS form 2728 |
| 54037-7 | HEDIS 2009 panel |
| 57820-3 | HEDIS 2010 panel |
| 60442-1 | HEDIS 2011 panel |
| 67767-4 | HEDIS 2012 panel |
| 72199-3 | HEDIS 2013 panel |
| 74234-6 | HEDIS 2014 Value Sets |
| 75868-0 | HEDIS 2015 Value Sets |
| 79544-3 | HEDIS 2016 Value Sets |
| 82955-6 | HEDIS 2017 Value Sets |
| 87625-0 | HEDIS 2018 Value Sets |
| 90766-7 | HEDIS 2019 Value Sets |
| 43150-2 | Hemoglobin A1c measurement device panel |
Language Variants Get Info
- zh-CNChinese (China)
- 血红蛋白 A1c/血红蛋白.总计:
质量分数: 时间点: 全血: 定量型: - nl-NLDutch (Netherlands)
- hemoglobine A1c/hemoglobine.totaal:
massafractie: moment: bloed: kwantitatief: - et-EEEstonian (Estonia)
- Hemoglobiin A1c/hemoglobiin.üld:
MFr: Pt: B: Qn: - fr-BEFrench (Belgium)
- Hémoglobine A1c/Hémoglobine.totale:
Fraction de masse: Temps ponctuel: Sang: Quantitatif: - fr-CAFrench (Canada)
- Hémoglobine A1c/Hémoglobine.totale:
Fraction de masse: Temps ponctuel: Sang: Quantitatif: - fr-FRFrench (France)
- Hemoglobin A1c/Hemoglobin.total:
MFr: Pt: Bld: Qn: - fr-CHFrench (Switzerland)
- Sg--hémoglobine A1c;
fraction de l'hémoglobine - de-ATGerman (Austria)
- Hämoglobin A1c
- de-DEGerman (Germany)
- Hämoglobin A1c/Hämoglobin.total:
SFr: Pkt: Blut: Qn: - de-CHGerman (Switzerland)
- B--Hämoglobin A1c;
Hämoglobinfraktion - it-ITItalian (Italy)
- Emoglobina A1c/Emoglobina.totale:
MFr: Pt: Sangue: Qn: - it-CHItalian (Switzerland)
- Sg--emoglobina A1c;
frazione dell'emoglobina - ko-KRKorean (Korea, Republic of)
- 혈색소 A1C/총혈색소:
질량분획: 검사시점: 전혈: 정량: - pt-BRPortuguese (Brazil)
- Hemoglobina A1c/Hemoglobina.total:
SFr: Pt: SgTotal: Qn: - ru-RURussian (Russian Federation)
- Гемоглобин А1с/Гемоглобин.общий:
МассДол: ТчкВрм: Кр: Колич: - es-ARSpanish (Argentina)
- hemoglobina A1c/hemoglobina.total:
fracción de masa: punto en el tiempo: sangre: cuantitativo: - es-ESSpanish (Spain)
- Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total:
Fracción de masa: Punto temporal: Sangre: Qn: - es-CHSpanish (Switzerland)
- Sg--hemoglobina A1c;
fracción de la hemoglobina - tr-TRTurkish (Turkey)
- Hemoglobin A1c/Hemoglobin.total:
KütlFr: Zmlı: Kan: Kant:
Example Units
| Unit | Source |
|---|---|
| % | eCHN |
| % | Example UCUM Units |
| % | Original Submission |
| % | REGENSTRIEF |
| % Hgb | REGENSTRIEF |
Units and Range
- Range
- %:[3.8,6.4];
- Unit Type
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=4548-4
LOINC Copyright
Copyright © 2019 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright