1751-7 Albumin [Mass/volume] in Serum or Plasma

Part Descriptions

LP6118-6   Albumin
A non-glycosylated protein that is synthesized in the liver parenchymal cells, regulated by colloid osmotic pressure from interstitial fluid surrounding hepatocytes, and catabolized in nearly all organs. Albumin comprises >50% of plasma proteins in plasma, CSF and urine, and therefore is a key contributor to intravascular oncotic pressure and regulating fluid concentration in tissues. Albumin also binds and transports a variety of endogenous substances and medications. Serum albumin measurement is a reflection of hydration and nutritional status, blood oncotic pressure, liver and kidney function, and other chronic diseases, and the ratio of albumin in the CSF and serum can be used to evaluate blood brain barrier disorders. [Tietz] Urine albumin of less than 30 mg/day is considered normal. Microalbuminuria is defined as urine albumin of 30-300 mg/day and is an early sign of kidney damage from disorders such as diabetes or hypertension. Albuminuria is urine albumin >300 mg/day and is associated with overt kidney disease. PMID: 25512779 Source: Regenstrief LOINC

Observation ID in Form

CMS-2728_Aa1

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Albumin

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

39

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Related Names

• Alb
• Chemistry
• Hepatology
• Kidney
• Level
• Liver
• Mass Concentration
• Nephrology
• Pl
• Plasma
• Plsm
• Point in time
• Protein.albumin
• QNT
• Quan
• Quant
• Quantitative
• Random
• Renal
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• UniversalLabOrders

Example Units

49049-0 Collection time of Specimen

Observation Required in Panel

Conditional

Fully-Specified Name

Component

Collection time

Property

TmStp

Time

Pt

System

^Specimen

Scale

Qn

Method

Basic Attributes

Class

SPEC

Type

Laboratory

First Released

Version 2.21

Last Updated

Version 2.73 (MIN)

Change Reason

Release 2.68: SYSTEM: Updated for consistency across terms

Order vs. Observation

Observation

Common Test Rank Get Info

1396

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Related Names

• Coll
• Collect
• Collect Tme
• Collected
• Date and time
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Spec
• Time stamp
• Timestamp

Example Units

68900-0 Albumin Lab Method

Observation ID in Form

CMS-2728_Aa3

Observation Required in Panel

Optional

Fully-Specified Name

Component

Albumin lab method

Property

Type

Time

Pt

System

Ser/Plas

Scale

Nom

Method

Long Common Name

Albumin lab method

Basic Attributes

Class

SURVEY.ESRD

Type

Surveys

First Released

Version 2.38

Last Updated

Version 2.42 (MIN)

Normative Answer List LL1902-7

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Related Names

• Alb
• ESRD
• ESRD survey
• Meth
• Method of
• Nominal
• Pl
• Plasma
• Plsm
• Point in time
• Protein.albumin
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• Survey
• Typ

2160-0 Creatinine [Mass/volume] in Serum or Plasma

Part Descriptions

LP14355-9   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Observation ID in Form

CMS-2728_Ab

Observation Required in Panel

Required

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Creatinine

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

4

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Related Names

• Chemistry
• CR
• Crea
• Creat
• Kidney
• Level
• Mass concentration
• Nephrology
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Renal
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• UniversalLabOrders

Example Units

718-7 Hemoglobin [Mass/volume] in Blood

Reference Information

Observation ID in Form

CMS-2728_Ac

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Hemoglobin

Property

MCnc

Time

Pt

System

Bld

Scale

Qn

Method

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

17

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Related Names

• Blood
• Haemoglobin
• Hb
• HEMATOLOGY/CELL COUNTS
• Hgb
• Level
• Mass concentration
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• UniversalLabOrders
• WB
• Whole blood

Example Units

Related Codes

4548-4 Hemoglobin A1c/Hemoglobin.total in Blood

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Reference Information

Observation ID in Form

CMS-2728_Ad

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Hemoglobin A1c/Hemoglobin.total

Property

MFr

Time

Pt

System

Bld

Scale

Qn

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Change Reason

Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.; Previous Releases: Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.

Order vs. Observation

Both

Common Test Rank Get Info

88

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Related Names

• Blood
• Chemistry
• Endocrine
• Endocrinology
• GHb
• Glycated hemoglobin
• Glycohaemogolobin
• Glycohemogolobin
• Glycosylated hemoglobin
• HA1c
• Haemoglobin
• Hb
• HbA1c
• Hgb
• Hgb A1c
• Mass fraction
• Percent
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Tot
• Totl
• WB
• Whole blood

Example Units

Related Codes

2093-3 Cholesterol [Mass/volume] in Serum or Plasma

Part Descriptions

LP15493-7   Cholesterol
Cholesterol is a lipidic, waxy alcohol found in the cell membranes and transported in the blood plasma of all animals. It is an essential component of mammalian cell membranes where it establishes proper membrane permeability and fluidity. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Cholesterol is classified as a sterol. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Cholesterol

Observation ID in Form

CMS-2728_Ae

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Cholesterol

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

61

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Related Names

• Cardio
• Cardiology
• Chemistry
• Chol
• Choles
• Cholest
• Cholesterol total
• Cholesterols
• Heart Disease
• Level
• Lipid
• Mass concentration
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• UniversalLabOrders

Example Units

13457-7 Cholesterol in LDL [Mass/volume] in Serum or Plasma by calculation

Observation ID in Form

CMS-2728_Ae

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Cholesterol.in LDL

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Calculated

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0j-a

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Observation

Common Test Rank Get Info

76

Formula (Readable)

Total cholesterol - HDL - (Triglyceride/5)

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Related Names

• Calc
• Calculation
• Cardio
• Cardiology
• Chemistry
• Chol
• Choles
• Cholest
• Cholesterol total
• Cholesterols
• Heart Disease
• LDLc
• LDL-C
• Level
• Lipid
• Low density lipoprotein cholesterol
• Low density lipoprotein cholesterols
• Mass concentration
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR

Example Units

2085-9 Cholesterol in HDL [Mass/volume] in Serum or Plasma

Part Descriptions

LP15489-5   Cholesterol.in HDL
Cholesterol is an essential lipid present in all cells. Cholesterol is needed in order to construct hormones, metabolites, and Vitamin D. Cholesterol travels throughout the bloodstream with the aid of two lipoproteins: high-density lipoprotein (HDL) and low-density lipoprotein (LDL). LDL carries cholesterol from the liver to other parts of the body and HDL carries cholesterol from other parts of the body to the liver where it can be broken down. HDL is considered "good cholesterol" because it removes excess cholesterol from the blood and into the liver where it can be disposed of properly. A higher level of HDL can decrease the risk for heart disease and atherosclerosis. When observing the blood HDL levels, less than 40 mg/dL is too low (high risk for heart disease), 40-59 mg/dL is average, and 60 mg/dL or higher is optimal (low risk for heart disease). Source: Regenstrief LOINC

Observation ID in Form

CMS-2728_Ae

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Cholesterol.in HDL

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

63

Member of these Panels

Member of these Groups Get Info

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Related Names

• Cardio
• Cardiology
• Chemistry
• Chol
• Choles
• Cholest
• Cholesterol total
• Cholesterols
• HDLc
• HDL-C
• Heart Disease
• High density lipoprotein cholesterols
• Level
• Lipid
• Mass concentration
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• TCHHDL
• UniversalLabOrders

Example Units

2571-8 Triglyceride [Mass/volume] in Serum or Plasma

Part Descriptions

LP15275-8   Triglyceride
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. There are many triglycerides, depending on the oil source, some are highly unsaturated, some less so. Triglycerides are the main constituents of vegetable oil (typically more unsaturated) and animal fats (typically more saturated). In humans, triglycerides are a mechanism for storing unused calories, and their high concentrations in blood correlates with the consumption of starchy and fatty foods. High levels of triglycerides in the bloodstream have been linked to atherosclerosis and, by extension, the risk of heart disease and stroke. Diets high in carbohydrates, with carbohydrates accounting for more than 60% of the total energy intake, can increase triglyceride levels. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Triglyceride (Wikipedia)

Observation ID in Form

CMS-2728_Ae

Observation Required in Panel

Optional

Type of Entry

Question expects user entry - requires response [Q]

Fully-Specified Name

Component

Triglyceride

Property

MCnc

Time

Pt

System

Ser/Plas

Scale

Qn

Method

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73 (MIN)

Order vs. Observation

Both

Common Test Rank Get Info

66

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Cardio
• Cardiology
• Chemistry
• Heart Disease
• Level
• Mass concentration
• Pl
• Plasma
• Plsm
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• SR
• Tg
• Trig
• Trigly
• Triglycerides
• Triglycrides
• UniversalLabOrders

Example Units

Related Codes