718-7 Hemogloblin (gm/dL)

Reference Information

Observation ID in Form

H11b

Fully-Specified Name

Component

Hemoglobin

Property

MCnc

Time

Pt

System

Bld

Scale

Qn

Method

Additional Names

Short Name

Hgb Bld-mCnc

Display Name

Hemoglobin (Bld) [Mass/Vol]

Consumer Name Alpha Get Info

Hemoglobin, Blood

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

17

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Blood
• Haemoglobin
• Hb
• HEMATOLOGY/CELL COUNTS
• Hgb
• Level
• Mass concentration
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• UniversalLabOrders
• WB
• Whole blood

Example Units

Related Codes

20570-8 Hematocrit (%)

Part Descriptions

LP15101-6   Hematocrit
The volume of packed red blood cells in a blood sample. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, in anemia the volume is low and in polycythemia it is high. Source: National Library of Medicine, MeSH 2006

Reference Information

Observation ID in Form

H12b

Fully-Specified Name

Component

Hematocrit

Property

VFr

Time

Pt

System

Bld

Scale

Qn

Method

Additional Names

Short Name

Hct VFr Bld

Display Name

Hematocrit (Bld) [Volume fraction]

Consumer Name Alpha Get Info

Hematocrit, Blood

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 1.0m

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

40

Member of these Panels

Language Variants Get Info

Related Names

• Blood
• Hct
• HEMATOLOGY/CELL COUNTS
• PCV
• Percent
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• UniversalLabOrders
• Volfr
• Volume fraction
• WB
• Whole blood

Example Units

Related Codes

26464-8 WBC (K/mm3)

Part Descriptions

LP14419-3   Leukocytes
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010) Source: Regenstrief LOINC

Reference Information

Observation ID in Form

H13b

Fully-Specified Name

Component

Leukocytes

Property

NCnc

Time

Pt

System

Bld

Scale

Qn

Method

Additional Names

Short Name

WBC # Bld

Display Name

WBC (Bld) [#/Vol]

Consumer Name Alpha Get Info

White blood cell (WBC) count, Blood

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 2.00

Last Updated

Version 2.73

Change Reason

Changed Order_Obs from 'Observation Only' to fit the current order use cases.

Order vs. Observation

Both

Common Test Rank Get Info

68

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• #
• ABS
• absolute
• absolutes
• Blood
• Cnt
• Count
• Count/volume
• CT
• HEMATOLOGY/CELL COUNTS
• Leuc
• Leuk
• Leukocyte
• Lkcs
• Number concentration
• Number Concentration (count/vol)
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• UniversalLabOrders
• WB
• WBC
• WBCs
• White blood cell
• White blood cells
• Whole blood

Example Units

4548-4 HbA1c (%)

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Reference Information

Observation ID in Form

H14b

Fully-Specified Name

Component

Hemoglobin A1c/Hemoglobin.total

Property

MFr

Time

Pt

System

Bld

Scale

Qn

Method

Additional Names

Short Name

HbA1c MFr Bld

Display Name

HbA1c (Bld) [Mass fraction]

Consumer Name Alpha Get Info

HbA1c/Total Hgb, Blood

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Change Reason

Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.; Previous Releases: Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.

Order vs. Observation

Both

Common Test Rank Get Info

88

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Blood
• Chemistry
• Endocrine
• Endocrinology
• GHb
• Glycated hemoglobin
• Glycohaemogolobin
• Glycohemogolobin
• Glycosylated hemoglobin
• HA1c
• Haemoglobin
• Hb
• HbA1c
• Hgb
• Hgb A1c
• Mass fraction
• Percent
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Tot
• Totl
• WB
• Whole blood

Example Units

Related Codes