Version 2.78

Part Description

LP212220-0   Microsatellite markers exhibiting instability
Microsatellite instability (MSI) is a change in the number of repeats of a specific DNA marker in cancer cells compared to the number of repeats present in non-cancerous cells of the same patient. Different tumor types are associated with different MSI markers, and both the presence of MSI in specific markers as well as the the number of distinct markers demonstrating MSI is important. Tumor cells are classified as being stable, having high instability (MSI-H), or having low instability (MSI-L) based on the number of markers demonstrating MSI. MSI analysis may help guide therapy and be a prognostic indicator. Specific MSI markers include BAT25, BAT26, D2S123, D5S346, D17S2720, NR21, NR24 and MONO27. MSI has been most studied in colorectal cancer, and colorectal tumors that are MSI-H are more likely to be carcinomas than adenomas. MSI has also been studied in other types of cancer, including gastric cancer, breast cancer, lung cancer and Wilms tumor. Source: Regenstrief LOINC

Fully-Specified Name

Component
Microsatellite markers exhibiting instability
Property
Num
Time
Pt
System
Cancer specimen
Scale
Qn
Method

Additional Names

Short Name
MSI mark found Ca spec
Display Name
Microsatellite markers exhibiting instability (Cancer specimen) [#]
Consumer Name Alpha Get Info
Microsatellite markers exhibiting instability, Cancer specimen

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.61
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because MSI testing is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85905-8 Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols
81711-4 Microsatellite instability marker panel - Cancer specimen

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Marcadores de inestabilidad de microsatelites:Número (recuento):Punto temporal:Muestra de cancer:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Marcadores de microsatélites que presentan inestabilidad:Número (recuento):Punto temporal:Espécimen de cáncer:Cuantitativo:
it-IT Italian (Italy) Marcatori di microsatelliti che dimostrano instabilità:Num:Pt:Campione tumore:Qn:
Synonyms: Campione di tumore Neoplasia maligna Numero (conta) Patologia Punto nel tempo (episodio)
zh-CN Chinese (China) 表现不稳定性的微卫星标记:数量(计数):时间点:癌标本:定量型:
Synonyms: 个数;数量;数量或计数（非负整数）;计数 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 受检物 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 表现（展现、体现、显现、显示、存在）不稳定性的微卫星标记 试样

Example Units

Unit Source
{#} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81709-8