Version 2.78

Term Description

Detects mutations in the Hepatitis C genotype 1 BS5b gene that are associated with resistance to nucleotide analog NS5b polymerase inhibitors such as sofosbuvir. The answer list contains three examples of the NS5b gene mutations.
Source: Regenstrief LOINC

Part Description

LP220303-4   Hepatitis C virus genotype 1 NS5b gene
Nonstructural protein 5B (NS5b) is a viral protein found in hepatitis C virus (HCV), and has the main function of replicating the HCV viral RNA by using the viral positive RNA strand as its template and catalyzing the polymerization of ribonucleoside triphosphates (rNTP). PMID: 22303022 The S282T mutation has been identified as the common variant that can confer resistance to sofosbuvir, however, this mutation is not generally present in untreated patients with HCV. PMID: 24883006 Source: Regenstrief LOINC

Fully-Specified Name

Component
Hepatitis C virus genotype 1 NS5b gene mutations detected
Property
Prid
Time
Pt
System
Isolate
Scale
Nom
Method
Genotyping

Additional Names

Short Name
HCV Genotyp 1 NS5b Mut Det Islt
Display Name
HCV genotype 1 NS5b gene mutations detected Genotyping Nom (Isol)
Consumer Name Alpha Get Info
Hepatitis C virus (HCV) genotype 1 NS5b gene variant analysis

Example Answer List: LL4044-5

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
S282T LA26381-6
L320F LA26389-9
C223H/Y LA26390-7
NoneCopyright http://snomed.info/sct ID:260413007 None (qualifier value)

Screen time

 LA137-2

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
14758

Member of these Panels

LOINC Long Common Name
82525-7 Hepatitis C virus genotype and drug resistance panel

Member of these Groups Get Info

LOINC Group Group Name
LG32754-0 Hepatitis C virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Hepatitis-C-Virus Genotyp 1 NS5b-Gen Mutationen entdeckt:Nachweis oder Identität:Zeitpunkt:Isolat:Nominal:Genotypisierung
es-ES Spanish (Spain) Gen NS5b del genotipo 1 del virus de la Hepatitis C Detección de mutaciones:Presencia o identidad:Punto temporal:Aislado:Nom:Susceptibilidad al genotipo viral
es-MX Spanish (Mexico) Se detectaron mutaciones en el gen NS5b del genotipo 1 del virus de la hepatitis C:Presencia o identidad:Punto temporal:Aislado:Nominal:Susceptibilidad del genotipo viral
fr-FR French (France) Hépatite C virus génotype 1 NS5b gène mutations détectées:Identification:Ponctuel:Isolat:Résultat nominal:Génotypage
it-IT Italian (Italy) Epatite C virus, genotipo 1 gene NS5b, mutazioni identificate:Prid:Pt:Isolato:Nom:Genotipizzazione
Synonyms: Gene NS5b genotipo 1 virus dell''epatite C Genotipo 1 virus dell''epatite C Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici Suscettibilità al genotipo virale Virus dell''epatite C
nl-NL Dutch (Netherlands) Hepatitis C-virus genotype 1 NS5b gen gedetecteerde mutaties:identificator:moment:isolaat:nominaal:genotypering
pl-PL Polish (Poland) Gen NS5b HCV, genotyp 1 wykryte mutacje:wykrycie lub identyfikacja:punkt w czasie:izolat:cecha:genotypowanie
Synonyms: Genotyp wirusa zapalenia wątroby typu C Wykryto mutacje genu NS5b wirusa zapalenia wątroby typu C genotypu 1
zh-CN Chinese (China) 丙型肝炎病毒基因型 1 NS5b 基因 已检出的突变:存在与否或特征标识:时间点:分离株:名义型:基因分型
Synonyms: Ⅰ C 型;丙;丙型 HCV;Hep C;丙型肝炎;丙肝;丙肝病毒;肝炎病毒 C 型 I 丙型肝炎病毒（C 型肝炎病毒、HCV、Hep C、丙肝病毒、肝炎病毒 C 型）基因型 1 丙型肝炎病毒（C 型肝炎病毒、HCV、Hep C、丙肝病毒、肝炎病毒 C 型）基因型 1 NS5b 基因 传染性肝炎 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 存在;存在与否;特征标识;身份;身份标识 已发现的突变 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 突变 突变类;基因突变 肝 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82381-5