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Term Description

Detects mutations in the Hepatitis C genotype 1 BS5b gene that are associated with resistance to nucleotide analog NS5b polymerase inhibitors such as sofosbuvir. The answer list contains three examples of the NS5b gene mutations.

Part Description

LP220303-4   Hepatitis C virus genotype 1 NS5b gene
Nonstructural protein 5B (NS5b) is a viral protein found in hepatitis C virus (HCV), and has the main function of replicating the HCV viral RNA by using the viral positive RNA strand as its template and catalyzing the polymerization of ribonucleoside triphosphates (rNTP). PMID: 22303022 The S282T mutation has been identified as the common variant that can confer resistance to sofosbuvir, however, this mutation is not generally present in untreated patients with HCV. PMID: 24883006 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Hepatitis C virus genotype 1 NS5b gene mutations detected:Prid:Pt:Isolate:Nom:Genotyping
Long Common Name
Hepatitis C virus genotype 1 NS5b gene mutations detected [Identifier]
Short Name
HCV Genotyp 1 NS5b Mut Det Islt
Display Name
HCV genotype 1 NS5b gene mutations detected Genotyping Nom (Isol)
Consumer Name Alpha Get Info
Hepatitis C virus (HCV) genotype 1 NS5b gene variant analysis

Part Model Get Info

  • Component
    Hepatitis C virus genotype 1 NS5b gene mutations detected
    LP220264-8
    • Analyte
      Hepatitis C virus genotype 1 NS5b gene mutations detected
      LP220264-8
      • Component Numerator
        Hepatitis C virus genotype 1 NS5b gene mutations detected
        LP220264-8
        • Component Numerator Core
          Hepatitis C virus genotype 1 NS5b gene
          LP220303-4
        • Component Numerator Core Suffix
          mutations detected
          LP32420-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Isolate
    LP7370-2
    • System Core
      Isolate
      LP7370-2
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Genotyping
    LP28723-2

Example Answer List: LL4044-5

Source: Quest Diagnostics Inc.
AnswerCodeScoreAnswer ID
S282TLA26381-6
L320FLA26389-9
C223H/YLA26390-7
NoneCopyright http://snomed.info/sct ID:260413007 None (qualifier value)LA137-2

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
14758

Member of these Panels

LOINCLong Common Name
82525-7Hepatitis C virus genotype and drug resistance panel

Member of these Groups Get Info

LOINC GroupGroup Name
LG32754-0Hepatitis C virus

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hepatitida C virus genotyp 1 gen NS5b detekované mutace:Přítomnost nebo identita:Časový bod:Izolát:Nominální:Genotypizace
de-DEGerman (Germany)Hepatitis-C-Virus Genotyp 1 NS5b-Gen Mutationen entdeckt:Nachweis oder Identität:Zeitpunkt:Isolat:Nominal:Genotypisierung
el-GRGreek (Greece)Ιός ηπατίτιδας C, γονότυπος 1 γονίδιο NS5b ανιχνευθείσες μεταλλάξεις:Prid:Pt:Απομονωμένο στέλεχος:Nom:Γονοτύπηση
Synonyms: ABXBACT C Nom Prid Pt ανιχνευθείσες μεταλλάξεις Απομονωμένο στέλεχος Γονίδιο Γονοτύπηση Ιός Ιός ηπατίτιδας C Ιός ηπατίτιδας C, γονότυπος 1 Ιός ηπατίτιδας C, γονότυπος 1 γονίδιο NS5b Μεταλλάξεις
es-ESSpanish (Spain)Gen NS5b del genotipo 1 del virus de la Hepatitis C Detección de mutaciones:Presencia o identidad:Punto temporal:Aislado:Nom:Susceptibilidad al genotipo viral
es-MXSpanish (Mexico)Se detectaron mutaciones en el gen NS5b del genotipo 1 del virus de la hepatitis C:Presencia o identidad:Punto temporal:Aislado:Nominal:Susceptibilidad del genotipo viral
fr-FRFrench (France)Hépatite C virus génotype 1 NS5b gène mutations détectées:Identification:Ponctuel:Isolat:Résultat nominal:Génotypage
it-ITItalian (Italy)Epatite C virus, genotipo 1 gene NS5b, mutazioni identificate:Prid:Pt:Isolato:Nom:Genotipizzazione
Synonyms: Gene NS5b genotipo 1 virus dell''epatite C Genotipo 1 virus dell''epatite C Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici Suscettibilità al genotipo virale Virus dell''epatite C
nl-NLDutch (Netherlands)Hepatitis C-virus genotype 1 NS5b gen gedetecteerde mutaties:identificator:moment:isolaat:nominaal:genotypering
pl-PLPolish (Poland)Gen NS5b HCV, genotyp 1 wykryte mutacje:obecność lub identyfikacja:punkt w czasie:izolat:skala nominalna:genotypowanie
Synonyms: Genotyp wirusa zapalenia wątroby typu C Wykryto mutacje genu NS5b wirusa zapalenia wątroby typu C genotypu 1 wynik kategorialny
zh-CNChinese (China)丙型肝炎病毒基因型 1 NS5b 基因 已检出的突变:存在与否或特征标识:时间点:分离株:名义型:基因分型
Synonyms: Ⅰ C 型;丙;丙型 HCV;Hep C;丙型肝炎;丙肝;丙肝病毒;肝炎病毒 C 型 I 丙型肝炎病毒（C 型肝炎病毒、HCV、Hep C、丙肝病毒、肝炎病毒 C 型）基因型 1 丙型肝炎病毒（C 型肝炎病毒、HCV、Hep C、丙肝病毒、肝炎病毒 C 型）基因型 1 NS5b 基因 传染性肝炎 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 存在;存在与否;特征标识;身份;身份标识 已发现的突变 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 突变 突变类;基因突变 肝 遗传基因;遗传因子;吉恩;生物基因

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82381-5