Version 2.77

Term Description

Qualitative detection of one or more carbapenemase resistance genes. To report the resistance gene(s) found, the carbapenem resistance genes identified term [LOINC: 63368-5] can be used.
Source: Regenstrief LOINC

Part Description

LP113695-3   Carbapenem resistance genes
Carbapenems are stable to AmpC β-lactamases and extended-spectrum-β-lactamases. Carbapenemases are a diverse group of b-lactamases that are active not only against the oxyimino-cephalosporins and cephamycins but also against the carbapenems. Aztreonam is stable to the metallo-β-lactamases but many IMP and VIM producers are resistant, owing to other mechanisms. Carbapenemases were formerly believed to derive only from classes A, B, and D, but a class C carbapenemase has been described.

IMP-type carbapenemases (one of the metallo-β-lactamases)(class B): Plasmid-mediated IMP-type carbapenemases, 17 varieties of which are currently known, found in enteric Gram-negative organisms, Pseudomonas and Acinetobacter species.

VIM (Verona integron-encoded metallo-β-lactamase): A second growing family of carbapenemases, the VIM family, VIM enzymes occur mostly in P. aeruginosa, also P. putidaand, very rarely, Enterobacteriaceae.

Both IMP and VIM hydrolyse all β-lactams except monobactams, and evade all β-lactam inhibitors.

OXA (oxacillinase) group of β-lactamases (Class D): The OXA group of β-lactamases occur mainly in Acinetobacter species and are divided into two clusters. OXA carbapenemases hydrolyse carbapenems very slowly in vitro, and the high MICs seen for some Acinetobacter hosts (>64 mg/L) may reflect secondary mechanisms. They are sometimes augmented in clinical isolates by additional resistance mechanisms, such as impermeability or efflux. OXA carbapenemases also tend to have a reduced hydrolytic efficiency towards penicillins and cephalosporins.

KPC (K. pneumoniae carbapenemase) (Class A): A few class A enzymes, most noted the plasmid-mediated KPC enzymes, are effective carbapenemases as well. Ten variants, KPC-2 through KPC-11 are known, and they are distinguished by one or two amino-acid substitutions

The class A Klebsiella pneumoniae carbapenemase (KPC) is currently the most common carbapenemase.

CMY (Class C): The first class C carbapenemase was described in 2006 and was isolated from a virulent strain of Enterobacter aerogenes. It is carried on a plasmid, pYMG-1, and is therefore transmissible to other bacterial strains. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Carbapenem resistance genes
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
CPR genes Islt/Spm Ql
Display Name
Carbapenem resistance genes Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Carbapenemresistance genes

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Carbapenem-Resistenzgene:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Genes de resistencia a carbapenamos:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Genes de resistencia a carbapenémicos:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR French (France) Carbapénèmases résistances gènes:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
fr-CA French (Canada) Gènes bactérien de résistance à la vancomycine vanA & vanB & vanC1 & vanC2:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
it-IT Italian (Italy) Geni carbapenem resistenti:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Geni carbapenem resistenti Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) carbapenemresistentie-genen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 碳青霉烯类耐药基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学 - 基因类 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 受检物 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 碳青霉烯类（碳青霉烯类抗生素、碳青霉烯）耐药基因;碳青霉烯酶（碳青黴烯酶、碳青霉烯水解酶）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）基因;碳青霉烯酶耐药基因类;碳青霉烯酶耐药基因 碳青霉烯类;碳青霉烯类抗生素 耐性 试样 阻力

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