95809-0
Carbapenem resistance genes [Presence] by Molecular method
Active
Term Description
Qualitative detection of one or more carbapenemase resistance genes. To report the resistance gene(s) found, the carbapenem resistance genes identified term LOINC 63368-5 can be used.
Part Description
LP113695-3 Carbapenem resistance genes
Carbapenems are stable to AmpC β-lactamases and extended-spectrum-β-lactamases. Carbapenemases are a diverse group of b-lactamases that are active not only against the oxyimino-cephalosporins and cephamycins but also against the carbapenems. Aztreonam is stable to the metallo-β-lactamases but many IMP and VIM producers are resistant, owing to other mechanisms. Carbapenemases were formerly believed to derive only from classes A, B, and D, but a class C carbapenemase has been described.
IMP-type carbapenemases (one of the metallo-β-lactamases)(class B): Plasmid-mediated IMP-type carbapenemases, 17 varieties of which are currently known, found in enteric Gram-negative organisms, Pseudomonas and Acinetobacter species.
VIM (Verona integron-encoded metallo-β-lactamase): A second growing family of carbapenemases, the VIM family, VIM enzymes occur mostly in P. aeruginosa, also P. putidaand, very rarely, Enterobacteriaceae.
Both IMP and VIM hydrolyse all β-lactams except monobactams, and evade all β-lactam inhibitors.
OXA (oxacillinase) group of β-lactamases (Class D): The OXA group of β-lactamases occur mainly in Acinetobacter species and are divided into two clusters. OXA carbapenemases hydrolyse carbapenems very slowly in vitro, and the high MICs seen for some Acinetobacter hosts (>64 mg/L) may reflect secondary mechanisms. They are sometimes augmented in clinical isolates by additional resistance mechanisms, such as impermeability or efflux. OXA carbapenemases also tend to have a reduced hydrolytic efficiency towards penicillins and cephalosporins.
KPC (K. pneumoniae carbapenemase) (Class A): A few class A enzymes, most noted the plasmid-mediated KPC enzymes, are effective carbapenemases as well. Ten variants, KPC-2 through KPC-11 are known, and they are distinguished by one or two amino-acid substitutions
The class A Klebsiella pneumoniae carbapenemase (KPC) is currently the most common carbapenemase.
CMY (Class C): The first class C carbapenemase was described in 2006 and was isolated from a virulent strain of Enterobacter aerogenes. It is carried on a plasmid, pYMG-1, and is therefore transmissible to other bacterial strains.
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Source: Wikipedia,
Wikipedia
LOINC Names Get Info
- Fully-Specified Name
- Carbapenem resistance genes:
PrThr: Pt: Isolate/Specimen: Ord: Molgen - Long Common Name
- Carbapenem resistance genes [Presence] by Molecular method
- Short Name
- CPR genes Islt/Spm Ql
- Display Name
- Carbapenem resistance genes Molgen Ql (Islt/Spec)
- Consumer Name Alpha Get Info
- Carbapenemresistance genes
Part Model Get Info
- Component
- Carbapenem resistance genes
LP113695-3
- Analyte
- Carbapenem resistance genes
LP113695-3
- Component Numerator
- Carbapenem resistance genes
LP113695-3
- Component Numerator Core
- Carbapenem resistance genes
LP113695-3
- Component Numerator Core Suffix
- NULL
- Component Denominator
- NULL
- Component Denominator Core
- NULL
- Component Denominator Core Suffix
- NULL
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- PrThr
LP217195-9
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- Isolate/Specimen
LP266970-5
- System Core
- Isolate/Specimen
LP266970-5
- Super System
- NULL
- Scale
- Ord
LP7751-3
- Method
- Molgen
LP6404-0
Example Answer List: LL744-4
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- ABXBACT
- Type
- Laboratory
- First Released
- Version 2.69
- Last Updated
- Version 2.69 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 104991-5 | Bacterial resistance panel |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Karbapenem geny rezistence: |
| de-DE | German (Germany) | Carbapenem-Resistenzgene: |
| el-GR | Greek (Greece) | Γονίδια ανθεκτικότητας στη καρβαπενέμη: Synonyms: ABXBACT Ord PrThr Pt Απομονωθέν στέλεχος/Δείγμα Απομονωμένο στέλεχος Γονίδια ανθεκτικότητας στη καρβαπενέμη Δείγμα Καρβαπενέμη Μοριακή γενετική |
| es-ES | Spanish (Spain) | Genes de resistencia a carbapenamos: |
| es-MX | Spanish (Mexico) | Genes de resistencia a carbapenémicos: |
| fr-FR | French (France) | Gènes de résistance aux carbapénèmases: |
| fr-CA | French (Canada) | Gène de résistance à Carbapénème: |
| it-IT | Italian (Italy) | Geni carbapenem resistenti: Synonyms: Genetica molecolare Geni carbapenem resistenti Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici |
| nl-NL | Dutch (Netherlands) | carbapenemresistentie-genen: Synonyms: isolaat/specimen molgen |
| pl-PL | Polish (Poland) | Geny oporności na karbapenemy: Synonyms: Antybiotyk karbapenemowy diagnostyka molekularna Geny warunkujące oporność na karbapenemy |
| zh-CN | Chinese (China) | 碳青霉烯类耐药基因: Synonyms: 供检查用的材料; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://