81630-6
Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells
Active
81628-0 Methotrexate monoglutamate [Moles/volume] in Red Blood Cells
Part Descriptions
LP212193-9 Methotrexate monoglutamate
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate monoglutamate
- Property
- SCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 16345
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Μεθοτρεξάτη μονογλουταμική: Synonyms: SCnc Μεθοτρεξάτη Μεθοτρεξάτη μονογλουταμική |
es-ES | Spanish (Spain) | Metotrexato-monoglutamato: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Monoglutamato de metotrexato: |
fr-FR | French (France) | Méthotrexate monoglutamate: |
it-IT | Italian (Italy) | Methotrexate monoglutammato: Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
zh-CN | Chinese (China) | 氨甲喋呤单谷氨酸: Synonyms: C20H22N8O5; |
Example Units
Unit | Source |
---|---|
nmol/L{RBCs} | Example UCUM Units |
81627-2 Methotrexate diglutamate [Moles/volume] in Red Blood Cells
Part Descriptions
LP212194-7 Methotrexate diglutamate
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate diglutamate
- Property
- SCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 16344
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Μεθοτρεξάτη διγλουταμινική: Synonyms: SCnc Μεθοτρεξάτη Μεθοτρεξάτη διγλουταμινική |
es-MX | Spanish (Mexico) | Diglutamato de metotrexato: |
es-ES | Spanish (Spain) | Metotrexato-diglutamato: Synonyms: Cuantitativo |
fr-FR | French (France) | Méthotrexate diglutamate: |
it-IT | Italian (Italy) | Methotrexate diglutammato: Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
pl-PL | Polish (Poland) | Diglutaminian metotreksatu: Synonyms: Diglutaminian metotreksatu |
zh-CN | Chinese (China) | 氨甲喋呤二谷氨酸: Synonyms: C20H22N8O5; |
Example Units
Unit | Source |
---|---|
nmol/L{RBCs} | Example UCUM Units |
81626-4 Methotrexate triglutamate [Moles/volume] in Red Blood Cells
Part Descriptions
LP212195-4 Methotrexate triglutamate
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate triglutamate
- Property
- SCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 16343
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Μεθοτρεξάτη τριγλουταμινική: Synonyms: SCnc Μεθοτρεξάτη Μεθοτρεξάτη τριγλουταμινική |
es-MX | Spanish (Mexico) | Triglutamato de metotrexato: |
es-ES | Spanish (Spain) | Metotrexato-triglutamato: Synonyms: Cuantitativo |
fr-FR | French (France) | Méthotrexate triglutamate: |
it-IT | Italian (Italy) | Methotrexate triglutammato: Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
zh-CN | Chinese (China) | 氨甲喋呤三谷氨酸: Synonyms: C20H22N8O5; |
Example Units
Unit | Source |
---|---|
nmol/L{RBCs} | Example UCUM Units |
81625-6 Methotrexate tetraglutamate [Moles/volume] in Red Blood Cells
Part Descriptions
LP212196-2 Methotrexate tetraglutamate
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate tetraglutamate
- Property
- SCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 14415
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Μεθοτρεξάτη τετραγλουταμική: Synonyms: SCnc Μεθοτρεξάτη Μεθοτρεξάτη τετραγλουταμική |
es-MX | Spanish (Mexico) | Tetraglutamato de metotrexato: |
es-ES | Spanish (Spain) | Metotrexato-tetraglutamato: Synonyms: Cuantitativo |
fr-FR | French (France) | Méthotrexate tétraglutamate: |
it-IT | Italian (Italy) | Methotrexate tetraglutammato: Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
zh-CN | Chinese (China) | 氨甲喋呤四谷氨酸: Synonyms: C20H22N8O5; |
Example Units
Unit | Source |
---|---|
nmol/L{RBCs} | Example UCUM Units |
81624-9 Methotrexate pentaglutamate [Moles/volume] in Red Blood Cells
Part Descriptions
LP212197-0 Methotrexate pentaglutamate
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate pentaglutamate
- Property
- SCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 16342
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Μεθοτρεξάτη πενταγλουταμινική: Synonyms: SCnc Μεθοτρεξάτη Μεθοτρεξάτη πενταγλουταμινική |
es-MX | Spanish (Mexico) | Pentaglutamato de metotrexato: |
es-ES | Spanish (Spain) | Metotrexato-pentaglutamato: Synonyms: Cuantitativo |
fr-FR | French (France) | Méthotrexate pentaglutamate: |
it-IT | Italian (Italy) | Methotrexate pentaglutammato: Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
zh-CN | Chinese (China) | 氨甲喋呤五谷氨酸: Synonyms: C20H22N8O5; |
Example Units
Unit | Source |
---|---|
nmol/L{RBCs} | Example UCUM Units |
76351-6 Methotrexate polyglutamates [Moles/volume] in Red Blood Cells
Part Descriptions
LP188434-7 Methotrexate polyglutamates
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate polyglutamates
- Property
- SCnc
- Time
- Pt
- System
- RBC
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- Added 's' to "polyglutamate" since result is based on multiple PGs (e.g. triglutamate, tetraglutamate, etc.)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 14042
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Πολυγλουταμινική μεθοτρεξάτη: Synonyms: SCnc Μεθοτρεξάτη Πολυγλουταμινική μεθοτρεξάτη |
es-MX | Spanish (Mexico) | Poliglutamatos de metotrexato: |
es-ES | Spanish (Spain) | Metotrexato poliglutamato: Synonyms: Cuantitativo |
fr-FR | French (France) | Méthotrexate polyglutamates: |
it-IT | Italian (Italy) | Metotrexato poliglutammati: Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | methotrexaat-polyglutamaat: Synonyms: rode bloedcellen |
tr-TR | Turkish (Turkey) | Metotreksat poliglutamat: Synonyms: RBC |
zh-CN | Chinese (China) | 氨甲蝶呤多聚谷氨酸: Synonyms: C20H22N8O5; |
Example Units
Unit | Source |
---|---|
nmol/L{RBCs} | Example UCUM Units |
81631-4 Methotrexate polyglutamates [Interpretation] in Red Blood Cells Narrative
Term Description
The overall interpretation of methotrexate polyglutamates (MTX-PGs) measurement results in red blood cells. Results are used to guide treatment planning and evaluation for various diseases, including rheumatoid arthritis.
Part Descriptions
LP188434-7 Methotrexate polyglutamates
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700
Source: Regenstrief LOINC
, PMID: 15677700
Fully-Specified Name
- Component
- Methotrexate polyglutamates
- Property
- Imp
- Time
- Pt
- System
- RBC
- Scale
- Nar
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.56 (ADD)
- Order vs. Observation
- Observation
Member of these Panels
LOINC | Long Common Name |
---|---|
81630-6 | Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Πολυγλουταμινική μεθοτρεξάτη: Synonyms: Imp Μεθοτρεξάτη Πολυγλουταμινική μεθοτρεξάτη |
es-ES | Spanish (Spain) | Metotrexato poliglutamato: |
es-MX | Spanish (Mexico) | Poliglutamatos de metotrexato: |
fr-FR | French (France) | Méthotrexate polyglutamates: |
it-IT | Italian (Italy) | Metotrexato poliglutammati: Synonyms: Globuli rossi Impressione/interpretazione di studio Livelli farmacologici e tossicologia Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | methotrexaat-polyglutamaat: Synonyms: rode bloedcellen |
tr-TR | Turkish (Turkey) | Metotreksat poliglutamat: Synonyms: RBC |
zh-CN | Chinese (China) | 氨甲蝶呤多聚谷氨酸: Synonyms: C20H22N8O5; |