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Part Description

LP247955-0   Glandular differentiation
The degree of glandular differentiation or tubule formation in breast carcinoma is one component of the Nottingham histologic grade (NHG) LOINC 44648-4, which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are nuclear pleomorphism LOINC 44645-0 and mitotic activity LOINC 85300-2. Less aggressive cancers have more tubule formation, with scores assigned as follows:
1 = greater than 75% of the tumor area contains tubular or glandular structures
2 = 10 to 75% of the tumor area contains tubular structures
3 = less than 10% of the tumor area contains tubular structures
PMID: 11865000 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Glandular differentiation:Score:Pt:Breast cancer specimen:SemiQn:Nottingham
Long Common Name
Glandular differentiation [Score] in Breast cancer specimen by Nottingham
Short Name
Gland diff Scre Br ca spec Nottingham
Display Name
Glandular differentiation Nottingham (Breast cancer specimen) [Score]
Consumer Name Alpha Get Info
Glandular differentiation, Breast cancer specimen

Part Model Get Info

  • Component
    Glandular differentiation
    LP247955-0
    • Analyte
      Glandular differentiation
      LP247955-0
      • Component Numerator
        Glandular differentiation
        LP247955-0
        • Component Numerator Core
          Glandular differentiation
          LP247955-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Score
    LP185820-0
  • Time
    Pt
    LP6960-1
  • System
    Breast cancer specimen
    LP247851-1
    • System Core
      Breast cancer specimen
      LP247851-1
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Nottingham
    LP248063-2

Normative Answer List: LL4380-3

Source: College of American Pathologists
AnswerCodeScoreAnswer ID
Score 1: >75% of tumor area forming glandular/tubular structures1LA27216-3
Score 2: 10% to 75% of tumor area forming glandular/tubular structures2LA27217-1
Score 3: <10% of tumor area forming glandular/tubular structures3LA27218-9
Only microinvasion present (not graded)0LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapy0LA27220-5
Score cannot be determined0LA27221-3

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.82 (MIN)
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
85904-1Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Žlázy diferenciace:Skóre:Časový bod:Vzorek karcinomu prsu:Semikvantitativní:Nottinghamská klasifikace
el-GRGreek (Greece)Αδενική διαφοροποίηση:Βαθμολογία:Pt:Δείγμα καρκίνου του μαστού:Ημιποσοτική:Nottingham
Synonyms: Nottingham PATH Pt Αδενική διαφοροποίηση Βαθμολογία Δείγμα Δείγμα καρκίνου Δείγμα καρκίνου του μαστού Ημιποσοτική Καρκίνος Μαστός
es-ESSpanish (Spain)difeencacion glandular:Puntuación:Punto temporal:Muestra de cancer de mama:Semicuantitativo:Nottingham
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Diferenciación glandular:Puntaje:Punto temporal:Muestra de cáncer de mama:Ordinal:Nottingham
it-ITItalian (Italy)Differenziazione ghiandolare:Punteggio:Pt:Tumore della mammella, campione:SemiQn:Nottingham
Synonyms: Campione di tumore Campione di tumore della mammella Neoplasia maligna Patologia Petto Punto nel tempo (episodio)
zh-CNChinese (China)腺体分化:评分:时间点:乳腺癌标本:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺癌（乳癌）标本（样本、样品、试样） 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分值;得分;分数 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85321-8