Version 2.78

Part Description

LP247955-0   Glandular differentiation
The degree of glandular differentiation or tubule formation in breast carcinoma is one component of the Nottingham histologic grade (NHG) [LOINC: 44648-4], which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are nuclear pleomorphism [LOINC: 44645-0] and mitotic activity [LOINC: 85300-2]. Less aggressive cancers have more tubule formation, with scores assigned as follows:
1 = greater than 75% of the tumor area contains tubular or glandular structures
2 = 10 to 75% of the tumor area contains tubular structures
3 = less than 10% of the tumor area contains tubular structures
PMID: 11865000 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glandular differentiation
Property
Score
Time
Pt
System
Breast cancer specimen
Scale
SemiQn
Method
Nottingham

Additional Names

Long Common Name
Glandular differentiation [Score] in Breast cancer specimen by Nottingham
Short Name
Gland diff Score Br ca spec Nottingham
Display Name
Glandular differentiation Nottingham (Breast cancer specimen) [Score]
Consumer Name Alpha Get Info
Glandular differentiation, Breast cancer specimen

Normative Answer List: LL4380-3

Source: College of American Pathologists
Answer Code Score Answer ID
Score 1: >75% of tumor area forming glandular/tubular structures 1 LA27216-3
Score 2: 10% to 75% of tumor area forming glandular/tubular structures 2 LA27217-1
Score 3: <10% of tumor area forming glandular/tubular structures 3 LA27218-9
Only microinvasion present (not graded) 0 LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapy 0 LA27220-5
Score cannot be determined 0 LA27221-3

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.75
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) difeencacion glandular:Puntuación:Punto temporal:Muestra de cancer de mama:Semicuantitativo:Nottingham
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Diferenciación glandular:Puntaje:Punto temporal:Muestra de cáncer de mama:Ordinal:Nottingham
it-IT Italian (Italy) Differenziazione ghiandolare:Punteggio:Pt:Tumore della mammella, campione:SemiQn:Nottingham
Synonyms: Campione di tumore Campione di tumore della mammella Neoplasia maligna Patologia Petto Punto nel tempo (episodio)
zh-CN Chinese (China) 腺体分化:评分:时间点:乳腺癌标本:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺癌（乳癌）标本（样本、样品、试样） 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分值;得分;分数 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85321-8