94586-5
Dermatan sulfate and heparan sulfate and keratan sulfate panel - DBS
Active
90233-8 Dermatan sulfate [Moles/volume] in DBS
Part Descriptions
LP15532-2 Dermatan sulfate
Dermatan sulfate is a derived disaccharide that accumulates in lysosomes, extracellular matrix, and body fluids of people with mucopolysaccharidoses (MPSs). MPSs are rare disorders caused by a deficiency of enzymes that break down glycosaminoglycans (GAGs). Symptoms of MPS vary due to which storage product accumulates and the level of enzymatic function or concentration that remains. Symptoms include musculoskeletal, airway, cardiac, and central nervous system disorders. Treatments include hematopoietic stem cell transplantation for the more critical forms of MPS and intravenous enzyme replacement therapy for the others. Treatment is most effective when it is initiated before irreversible tissue damage has occurred. Because MPS is so rare and the symptoms so variable, it is difficult to diagnose in its earliest stages. A solution to that problem is the development of newborn screening assays that can detect dermatan sulfate, though the levels in the dried blood spot samples do not appear to predict the severity of disease. The pattern of dermatan and heparan sulfate can help distinguish between the different MPSs. PMID: 23084433
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Dermatan sulfate
- Property
- SCnc
- Time
- Pt
- System
- Bld.dot
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94586-5 | Dermatan sulfate and heparan sulfate and keratan sulfate panel - DBS |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Θειική δερματάνη: Synonyms: SCnc Θειικά άλατα Θειική δερματάνη |
| es-ES | Spanish (Spain) | Dermatan sulfato: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sulfato de dermatán: |
| et-EE | Estonian (Estonia) | Dermataansulfaat: Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Veri |
| fr-FR | French (France) | Dermatane sulfate: |
| fr-CA | French (Canada) | Dermatane sulfate: |
| fr-BE | French (Belgium) | Dermatane-sulfate: Synonyms: SO4 |
| it-IT | Italian (Italy) | Dermatan solfato: Synonyms: Chimica Concentrazione di Sostanza Punto nel tempo (episodio) Sangue Spot sangue secco |
| nl-NL | Dutch (Netherlands) | dermatansulfaat: |
| ru-RU | Russian (Russian Federation) | Дерматан сульфат: Synonyms: Дерматансульфат Количественный Кровь Кровь сухая капля Молярность; |
| tr-TR | Turkish (Turkey) | Dermatan sülfat: |
| zh-CN | Chinese (China) | 硫酸皮肤素: Synonyms: SO4; |
Example Units
| Unit | Source |
|---|---|
| nmol/L | Example UCUM Units |
90235-3 Heparan sulfate [Moles/volume] in DBS
Part Descriptions
LP15629-6 Heparan sulfate
Heparan sulfate is a derived disaccharide that accumulates in lysosomes, extracellular matrix, and body fluids of people with mucopolysaccharidoses (MPSs). MPSs are rare disorders caused by a deficiency of enzymes that break down glycosaminoglycans (GAGs). Symptoms of MPS vary due to which storage product accumulates and the level of enzymatic function or concentration that remains. Symptoms include musculoskeletal, airway, cardiac, and central nervous system disorders. Treatments include hematopoietic stem cell transplantation for the more critical forms of MPS and intravenous enzyme replacement therapy for the others. Treatment is most effective when it is initiated before irreversible tissue damage has occurred. Because MPS is so rare and the symptoms so variable, it is difficult to diagnose in its earliest stages. A solution to that problem is the development of newborn screening assays that can detect heparan sulfate, though the levels in the dried blood spot samples do not appear to predict the severity of disease. The pattern of dermatan and heparan sulfate can help distinguish between the different MPSs. PMID: 23084433
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Heparan sulfate
- Property
- SCnc
- Time
- Pt
- System
- Bld.dot
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94586-5 | Dermatan sulfate and heparan sulfate and keratan sulfate panel - DBS |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Θειική ηπαράνη: Synonyms: SCnc Θειικά άλατα Θειική ηπαράνη |
| es-MX | Spanish (Mexico) | Sulfato de Heparán: |
| es-ES | Spanish (Spain) | Heparán sulfato: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Heparaansulfaat: Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Veri |
| fr-BE | French (Belgium) | Héparane-sulfate: Synonyms: SO4 |
| fr-CA | French (Canada) | Héparane sulfate: |
| fr-FR | French (France) | Héparane sulfate: |
| it-IT | Italian (Italy) | Eparan solfato: Synonyms: Chimica Concentrazione di Sostanza Punto nel tempo (episodio) Sangue Spot sangue secco |
| nl-NL | Dutch (Netherlands) | heparansulfaat: |
| ru-RU | Russian (Russian Federation) | Гепаран сульфат: Synonyms: Гепарансульфат Количественный Кровь Кровь сухая капля Молярность; |
| tr-TR | Turkish (Turkey) | Heparan sülfat: |
| zh-CN | Chinese (China) | 硫酸类肝素: Synonyms: SO4; |
Example Units
| Unit | Source |
|---|---|
| nmol/L | Example UCUM Units |
90236-1 Keratan sulfate [Moles/volume] in DBS
Part Descriptions
LP14490-4 Keratan sulfate
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
Source: National Library of Medicine, MeSH 2006
LP14490-4 Keratan sulfate
Keratan sulfate (KS) is one of the glycosaminoglycans found primarily in the cornea, nervous tissue, and bone. When the enzyme that breaks down KS is deficient or absent, KS accumulates in lysosomes which results in cell, tissue, and organ dysfunction. The lysosomal storage disorders are known as mucopolysaccharidoses (MPS) and can involve impaired enzymatic function that blocks the catabolism of any of the glycosaminoglycans, including dermatan sulfate, heparin sulfate, keratan sulfate, chondroitin sulfate, or hyaluronan. MPS due to the accumulation of any one or more glycosaminoglycans have many symptoms in common including a chronic or progressive course, multisystem involvement, organomegaly, dysostosis multiplex, abnormal facies, affected hearing, affected vision, affected airway, cardiovascular issues, profound mental retardation, and joint mobility difficulties. MPS can be diagnosed by testing for the deficient or absent enzyme. Enzyme replacement therapy is used to monitor treatment.[https://ommbid.mhmedical.com/content.aspx?bookid=971§ionid=62642135]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Keratan sulfate
- Property
- SCnc
- Time
- Pt
- System
- Bld.dot
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94586-5 | Dermatan sulfate and heparan sulfate and keratan sulfate panel - DBS |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Θειική κερατάνη: Synonyms: SCnc Θειικά άλατα Θειική κερατάνη |
| es-ES | Spanish (Spain) | Queratán sulfato: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sulfato de queratán: |
| et-EE | Estonian (Estonia) | Kerataansulfaat: Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Veri |
| fr-FR | French (France) | Kératane sulfate: |
| fr-BE | French (Belgium) | Sulfate de kératane: Synonyms: SO4 |
| fr-CA | French (Canada) | Sulfate de kératane: |
| it-IT | Italian (Italy) | Cheratan solfato: Synonyms: Chimica Concentrazione di Sostanza Punto nel tempo (episodio) Sangue Spot sangue secco |
| nl-NL | Dutch (Netherlands) | keratansulfaat: |
| ru-RU | Russian (Russian Federation) | Кератансульфат: Synonyms: Количественный Кровь Кровь сухая капля Молярность; |
| tr-TR | Turkish (Turkey) | Keratan sülfat: |
| zh-CN | Chinese (China) | 硫酸角质素: Synonyms: SO4; |
Example Units
| Unit | Source |
|---|---|
| nmol/L | Example UCUM Units |