94855-4
carBAMazepine hypersensitivity genotype panel - Blood or Tissue
Active
57979-7 HLA-B*15:02 [Presence]
Part Descriptions
LP97940-8 HLA-B*15:02
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Antiepileptics with an aromatic ring, for example carbamazepine and phenytoin, interact with HLA-B*15:02 and alter the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as Stevens-Johnson syndrome or toxic epidermal necrolysis. PMID: 23695185 PMID: 25099164. See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- HLA-B*15:02
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
Additional Names
- Short Name
- HLA-B*15:02 Ql
- Display Name
- HLA-B*15:02 Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- HLA-B*15:02, Blood or tissue specimen
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.29
- Last Updated
- Version 2.73
- Change Reason
- This test is commonly performed on cells found in saliva and buccal swabs as well as blood specimens. Changed specimen from 'Bld' to 'Bld/Tiss' to represent both specimen types.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 15170
Preferred Answer List LL360-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94855-4 | carBAMazepine hypersensitivity genotype panel - Blood or Tissue |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | HLA-B * 15: |
| es-ES | Spanish (Spain) | HLA-B*15: |
| et-EE | Estonian (Estonia) | HLA-B*1502: Synonyms: Järgarvuline Juhuslik Kude Veri Veri või koematerjal |
| fr-CA | French (Canada) | HLA-B*15: |
| fr-BE | French (Belgium) | HLA-B*1502: |
| fr-FR | French (France) | HLA-B*15: |
| it-IT | Italian (Italy) | HLA-B*15: Synonyms: HLA tipizzazione tissutale antigeni-anticorpi Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | HLA-B*1502: |
| pt-BR | Portuguese (Brazil) | HLA-B*1502: Synonyms: Human Leukocyte Antigen; |
| ru-RU | Russian (Russian Federation) | HLA-B*1502: Synonyms: Кровь Кровь или Ткань Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | HLA-B*1502: Synonyms: Mevcut |
| zh-CN | Chinese (China) | HLA-B*15: Synonyms: B 型 HLA 抗原; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
79712-6 HLA-A*31:01 [Presence] in Blood or Tissue
Part Descriptions
LP203038-7 HLA-A*31:01
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Antiepileptics with an aromatic ring, for example carbamazepine and phenytoin, interact with HLA-B*31:01 and alter the repertoire of self peptides that are presented to T lymphocytes, which activates an immune reaction known as Stevens-Johnson syndrome or toxic epidermal necrolysis. PMID: 23695185 PMID: 25099164 See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- HLA-A*31:01
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
Additional Names
- Short Name
- HLA-A*31:01 Bld/T Ql
- Display Name
- HLA-A*31:01 Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- HLA-A*31:01, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Preferred Answer List LL360-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94855-4 | carBAMazepine hypersensitivity genotype panel - Blood or Tissue |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | HLA-A * 31: |
| es-ES | Spanish (Spain) | HLA-A*31: |
| fr-FR | French (France) | HLA-A*31: |
| it-IT | Italian (Italy) | HLA-A*31: Synonyms: Farmacogenomica Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | HLA-A*31: |
| tr-TR | Turkish (Turkey) | HLA-A*31: Synonyms: Mevcut |
| zh-CN | Chinese (China) | HLA-A*31: Synonyms: A 型 HLA 抗原; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
93308-5 Genetic variation's effect on risk of adverse drug reaction
Term Description
The predicted risk of an adverse drug reaction based on the variant(s) detected. For example, a patient who is HLA-B*57:01 positive has a significant risk of abacavir hypersensitivity reactions (HSR). For individuals taking pazopanib and found to be HLA-B*57:01 carriers, they have an increased risk of elevated alanine aminotransferase (ALT) levels when taking pazopanib.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Risk of adverse drug reaction sequence variation interpretation
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nar
- Method
Additional Names
- Short Name
- Adverse drug seq var interp Bld/T-Imp
- Display Name
- Risk of adverse drug reaction sequence variation interpretation Nar (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- Risk of adverse drug reaction sequence variation interpretation, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.67
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94855-4 | carBAMazepine hypersensitivity genotype panel - Blood or Tissue |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Riesgo de interpretación de la variación de la secuencia de reacciones adversas al fármaco: |
| es-ES | Spanish (Spain) | Riesgo de interpretación de variación de secuencia de reacción adversa al fármaco: |
| fr-FR | French (France) | Risque de variation de la séquence des effets indésirables d'un médicament interprétation: |
| it-IT | Italian (Italy) | Rischio di interpretazione della variazione della sequenza di reazione avversa al farmaco: Synonyms: Farmacogenomica Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| zh-CN | Chinese (China) | 药物不良反应序列变异风险解释: Synonyms: React Rxn 不良药物反应史 全血或组织; |