Version 2.78

83082-8 Cancer Ag 125 [Units/volume] in Serum or Plasma by Immunoassay

Term Description

This term was created for, but is not limited in use to, bioMerieux's VIDAS CA 125 II assay, which is intended for the quantitative measurement of the OC
125 antigenic determinants in human serum or plasma.
Source: Regenstrief LOINC

Part Descriptions

LP14543-0   Cancer Ag 125
CA 125 is an antigenic determinant associated with a mucin-like glycoprotein, molecular weight exceeding 500,000 Daltons. This determinant is recognized by the murine monoclonal antibody OC 125, which reacts with over 80% of epithelial ovarian cancers. Elevated CA 125 levels have been reported in subjects with serous, endometrioid, clear cell, and undifferentiated ovarian carcinoma adenocarcinoma of the endometrium or fallopian tube, as well as some nongynocologic malignancies and certain nonmalignant conditions. Elevated levels also have been observed in pregnant women, most often during the first trimester. CA 125 levels may have significant value in monitoring ovarian carcinoma patients. A persistently rising CA 125 value may be associated with progressive malignant disease and poor therapeutic response. A declining CA 125 value is indicative of favorable prognosis and good response to treatment. CA 125 levels may help predict whether an invasive second-look procedure such as laparoscopy or laparotomy is required after treatment for epithelial ovarian cancer.
I.A. KOELMA, M. NAP, C.J. RODENBURG, G.J. FLEUREN (1987) The value of tumour marker CA 125 in surgical pathology
Histopathology 11 (3) , 287-294 doi:10.1111/j.1365-2559.1987.tb02633. Source: Regenstrief Institute

Fully-Specified Name

Component
Cancer Ag 125
Property
ACnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Short Name
Cancer Ag125 SerPl IA-aCnc
Display Name
Cancer Ag 125 IA Qn
Consumer Name Alpha Get Info
Cancer Ag 125, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
18720

Member of these Panels

LOINC Long Common Name
104551-7 Ovarian malignancy (ROMA) panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG108-7 Cancer Ag 125|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Cancer Antigen 125:Arbiträre Konzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Immunoassay
Synonyms: CA 125
el-GR Greek (Greece) Καρκινικό αντιγόνο 125:Αυθαίρετη συγκέντρωση:Χρονική στιγμή:Ορός/Πλάσμα:Ποσοτική:IA
Synonyms: CA 125
es-MX Spanish (Mexico) Cáncer Ag 125:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
es-ES Spanish (Spain) Ag de cáncer 125:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Kasvajaantigeen CA 125:Acnc:Pt:S/P:Qn:IA
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Ag carbohydraté 125:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-FR French (France) Carbohydrate antigène 125:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
fr-BE French (Belgium) Ag carbohydraté 125:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
Synonyms: Ca 125
it-IT Italian (Italy) Cancro, Ag 125:ACnc:Pt:Siero/Plasma:Qn:IA
Synonyms: Antigene 125 di cancro Chimica Concentrazione Arbitraria Immunoassay Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) CA125:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay
Synonyms: IA kanker Ag 125
pl-PL Polish (Poland) CA 125 Ag:stężenie w jednostkach umownych:punkt w czasie:surowica lub osocze:ilościowy:metoda immunologiczna
Synonyms: Antygen CA 125
ru-RU Russian (Russian Federation) Раковый Аг 125:ПроизвКонц:ТчкВрм:Сыв/Плаз:Колич:IA
Synonyms: Количественный Плазма Произвольная концентрация Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Kanser Ag 125:SçKons:Zmlı:Ser/Plaz:Kant:İA
Synonyms: İmmünölçüm, immünoassay
zh-CN Chinese (China) 癌抗原 125:任意型浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: CA CA 125;OC125;癌 Ag 125;癌抗原 125（Cancer Antigen 125，CA 125） 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 癌 癌 Ag 癌症抗原 血清或血浆

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

55180-4 Human epididymis protein 4 [Moles/volume] in Serum or Plasma

Part Descriptions

LP93517-8   Human epididymis protein 4
Human epididymis protein 4 (known as HE4, or as WAP four-disulfide core domain protein 2) is a protein that in humans is encoded by the WFDC2 gene and belongs to the family of whey acidic four-disulfide core (WFDC) proteins. HE4 is overexpressed in both ovarian and endometrial cancers and is an important biomarker that complements CA 125 in discriminating between benign and malignant pelvic masses, monitoring response to treatment, and detecting recurrences of both ovarian and endometrial cancer. The risk of ovarian malignancy algorithm (ROMA) includes CA 125, HE4, and menopausal status to distinguish benign from malignant adnexal masses. HE4 may augment the sensitivity of CA 125 for detecting early-stage ovarian cancer. PMID: 23909069 Source: Regenstrief LOINC, PMID: 23909069

Reference Information

Type Source Reference
Fda 510K Regenstrief Help FDA_510k

Fully-Specified Name

Component
Human epididymis protein 4
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
HE4 SerPl-sCnc
Display Name
Human epididymis protein 4 [Moles/Vol]
Consumer Name Alpha Get Info
Human epididymis protein 4, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.27
Last Updated
Version 2.73
Change Reason
System changed from serum to fit the updated procedures.
Order vs. Observation
Both
Common Test Rank Get Info
4718

Member of these Panels

LOINC Long Common Name
104551-7 Ovarian malignancy (ROMA) panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG51042-6 Human epididymis protein 4|Pt|Ser/Plas
LG22449-9 Human epididymis protein 4|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: HE4
es-ES Spanish (Spain) Proteína 4 del epidídimo humano:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Proteína 4 del epidídimo humano:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Kasvajaantigeen HE4:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Protéine 4 épididyme humaine:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-BE French (Belgium) Protéine 4. épididyne humain:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Protéine HE4:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Epididimo umano, proteina 4:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Proteina 4 dell''epididimo umano Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) Humaan epididymis proteïne 4:mol/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Proteína humana epidídimo 4:#N/A:Pt:Soro:Qn:
Synonyms: ; Prot; PR; HE4; Substance concentration; Level; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Человеческий придаток яичка протеин 4:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Белок Белок 4 эпидидимиса человека Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Human epididymis protein 4:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 人附睾蛋白 4:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 人类附睾蛋白 4;HE4;Human epididymal protein 4;人附睾上皮分泌蛋白 4;人附睾分泌蛋白 4 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

Unit Source
pmol/L Example UCUM Units

69570-0 Risk of ovarian malignancy algorithm score in Serum or Plasma --postmenopausal

Term Description

In the formula for the ROMA score, the HE4 is in units of pmol/L and the CA125 is in units of "U/ml". (Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 3, Pages 521-525)
According to Abbott website, the formula can be used ONLY with results determined using the ARCHITECT method due to variability conferred by reagents/method. (http://www.abbottdiagnostics.com.au/Products/Instruments_by_Platform/roma.cfm#form).
Source: Regenstrief LOINC

Part Descriptions

LP140230-6   Risk of ovarian malignancy algorithm score
The Risk of Ovarian Malignancy Algorithm (ROMA) is a qualitative serum test that combines the results of human epididymis protein 4 (HE4) by EIA, testing for cancer Ag 125 and the patient's menopausal status into a numerical score. The ROMA score is intended to aid in assessing whether a premenopausal or postmenopausal woman who presents with an ovarian adnexal mass is at a low or high likelihood of finding malignancy at surgery. ROMA is indicated for women who meet the following criteria: over age 18; ovarian adnexal mass present for which surgery is planned, and not yet referred to an oncologist. The ROMA score must be interpreted in conjunction with an independent clinical and radiological assessment. Source: LOINC partner 1

Fully-Specified Name

Component
Risk of ovarian malignancy algorithm score^postmenopausal
Property
Score
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
ROMA score postmen SerPl
Display Name
Risk of ovarian malignancy algorithm score postmenopausal [Score]
Consumer Name Alpha Get Info
Risk of ovarian malignancy algorithm score Postmenopausal, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
8219

Formula (Readable)

Postmenopausal calculation = Predictive Index (PI) = -8.09 + 1.04 *LN(HE4) + 0.732 * LN(CA125) ROMA = exp(PI) / [1 + exp(PI)] *10

Member of these Panels

LOINC Long Common Name
104551-7 Ovarian malignancy (ROMA) panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: ROMA Index postmeno.
es-MX Spanish (Mexico) Puntuación del algoritmo de riesgo de malignidad ovárica ^ posmenopáusica:Puntaje:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Algoritmo de puntuación para el riesgo de malignidad ovárica^post menopausia:Puntuación:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Risque de malignité ovarienne score Post-ménopause:Score:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Algoritmo di rischio di malignità ovarica, punteggio^post menopausa:Punteggio:Pt:Siero/Plasma:Qn:
Synonyms: Chimica dopo menopausa Plasma Punteggio di rischio di malignità ovarica Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) risico voor ovariële maligniteit algoritmescore^postmenopausaal:score:moment:serum of plasma:kwantitatief:
tr-TR Turkish (Turkey) Over malignansi algoritma skoru riski^postmenapozal:Skor:Zmlı:Ser/Plaz:Kant:
Synonyms: Puan
zh-CN Chinese (China) 卵巢恶性肿瘤风险算法评分^绝经后:评分:时间点:血清/血浆:定量型:
Synonyms: 分值;分数;得分 分值;得分;分数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 卵巢恶性肿瘤风险算法评分（分数、分值、得分）;卵巢肿瘤风险算法评分 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 恶性程度;恶性肿瘤 时刻;随机;随意;瞬间 绝经后的;绝经期 血清或血浆

Example Units

Unit Source
{score} Example UCUM Units

69569-2 Risk of ovarian malignancy algorithm score in Serum or Plasma --premenopausal

Term Description

In the formula for the ROMA score, the HE4 is in units of pmol/L and the CA125 is in units of "U/ml". (Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 3, Pages 521-525)
According to Abbott website, the formula can be used ONLY with results determined using the ARCHITECT method due to variability conferred by reagents/method. (http://www.abbottdiagnostics.com.au/Products/Instruments_by_Platform/roma.cfm#form).
Source: Regenstrief LOINC

Part Descriptions

LP140230-6   Risk of ovarian malignancy algorithm score
The Risk of Ovarian Malignancy Algorithm (ROMA) is a qualitative serum test that combines the results of human epididymis protein 4 (HE4) by EIA, testing for cancer Ag 125 and the patient's menopausal status into a numerical score. The ROMA score is intended to aid in assessing whether a premenopausal or postmenopausal woman who presents with an ovarian adnexal mass is at a low or high likelihood of finding malignancy at surgery. ROMA is indicated for women who meet the following criteria: over age 18; ovarian adnexal mass present for which surgery is planned, and not yet referred to an oncologist. The ROMA score must be interpreted in conjunction with an independent clinical and radiological assessment. Source: LOINC partner 1

Fully-Specified Name

Component
Risk of ovarian malignancy algorithm score^premenopausal
Property
Score
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
ROMA score premen SerPl
Display Name
Risk of ovarian malignancy algorithm score premenopausal [Score]
Consumer Name Alpha Get Info
Risk of ovarian malignancy algorithm score Premenopausal, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
9029

Formula (Readable)

Premenopausal calculation = Predictive Index (PI) = -12.0 + 2.38 *LN(HE4) + 0.0626 * LN(CA125) ROMA = exp(PI) / [1 + exp(PI)] *10

Member of these Panels

LOINC Long Common Name
104551-7 Ovarian malignancy (ROMA) panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: ROMA Index prämeno.
es-MX Spanish (Mexico) Puntuación del algoritmo de riesgo de malignidad de ovario ^ premenopáusicas:Puntaje:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Algoritmo de puntuación para el riesgo de malignidad ovárica^premenopausia:Puntuación:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Risque de malignité ovarienne score ROMA préménopause:Score:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Algoritmo di rischio di malignità ovarica, punteggio^pre menopausa:Punteggio:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Plasma prima di menopausa Punteggio di rischio di malignità ovarica Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) risico voor ovariële maligniteit algoritmescore^premenopausaal:score:moment:serum of plasma:kwantitatief:
tr-TR Turkish (Turkey) Over malignansi algoritma skoru riski^premenopozal:Skor:Zmlı:Ser/Plaz:Kant:
Synonyms: Puan
zh-CN Chinese (China) 卵巢恶性肿瘤风险算法评分^绝经前:评分:时间点:血清/血浆:定量型:
Synonyms: 分值;分数;得分 分值;得分;分数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 卵巢恶性肿瘤风险算法评分（分数、分值、得分）;卵巢肿瘤风险算法评分 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 恶性程度;恶性肿瘤 时刻;随机;随意;瞬间 绝经期前;绝经前期的;绝经前期 血清或血浆

Example Units

Unit Source
{score} Example UCUM Units