Version 2.78

88874-3 Mycobacterium tuberculosis complex DNA [Presence] in Isolate or Specimen by Molecular genetics method

Part Descriptions

LP39079-6   Mycobacterium tuberculosis complex DNA
The Mycobacterium tuberculosis complex (MTBC) is a taxonomic group of Mycobacterium that includes M. tuberculosis, M. bovis, M Bovis BCG, M. africanum, M caprae, M. microti, M canettii, M pinnipedii, M mungi, and M orygis. Their nucleotide sequences only differ from each other by .01 to .03% and though they are so genetically similar they differ widely in epidemiology.[Manual of Clinical Microbiology p538]. To differentiate the species of mycobacterium polymerase chain reaction (PCR) is used to analyze the presence or absence of the regions of difference (RD) of the genomes. There are 16 regions of difference that have been identified and can be analyzed to determine the species of the mycobacterium. In one study, initial screenings of isolates only required analysis of RD1, RD9 and RD10. If the results of the RD1, RD9 and RD10 were all negative, then RD3, RD5 and RD11 were tested and able to identify the remaining species. PMID: 12089245 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex DNA
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
M TB Cmplx DNA Islt/Spm Ql
Display Name
M. tuberculosis complex DNA Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis complex

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
5458

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
89371-9 MTB complex DNA and rpoB RIF resistance mutation panel [Presence]
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method
94053-6 Mycobacterium tuberculosis complex resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium-tuberculosis-Komplex DNA:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Complejo micobacterim tuberculosis ADN:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) ADN del complejo Mycobacterium tuberculosis:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-CA French (Canada) Mycobacterium tuberculosis complex, ADN:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
fr-FR French (France) Mycobacterium complexe tuberculosis ADN:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis complex DNA:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Complesso di micobatteri della tubercolosi Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Microbiologia Presenza o Soglia Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis complex DNA:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
uk-UA Ukrainian (Ukraine) Mycobacterium tuberculosis комплекс ДНК:Наявність або Поріг:МоментЧасу:Ізолят/Зразок:Порядково:Молекулярна генетика
Synonyms: Acid Fast; Acid Fast Bacilli; Acid fast bacillus; AFB; Compx; Deoxyribonucleic acid; ID; Infectious Disease; InfectiousDisease; Islt; Islt/Spm; Isol; M tb; M TB Cmplx; M tuberculosis; Microbiology; Molecular genetics; Mtb; MTBC; Myco; Mycobact; Mycobacterium tuberculosum; Ordinal; PCR; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Spec; TB; Tuberculosis
zh-CN Chinese (China) 结核分枝杆菌复合菌群 DNA:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 受检物 复合体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 时刻;随机;随意;瞬间 样品 样本 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分支杆菌复合体 DNA 结核分支杆菌复合群 DNA 结核分支杆菌复合菌群 DNA 结核分枝杆菌复合体 DNA 结核分枝杆菌复合物 DNA 结核分枝杆菌复合菌群（复合群、复合菌、复合体、复合物）;结核分支杆菌复合体;结核分支杆菌复合群;结核分支杆菌复合菌群;结核分枝杆菌复合体;结核分枝杆菌复合物;结核分枝杆菌结核菌群;结核杆菌复合菌群 结核分枝杆菌结核菌群 DNA 结核杆菌复合菌群 DNA 结核病 肺结核 试样

89372-7 Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation [Presence] by Molecular method

Part Descriptions

LP267160-2   Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
MTB rpoB RIF resist mut Islt/Spm Ql
Display Name
M. tuberculosis complex rpoB gene rifAMPin resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
7128

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
89371-9 MTB complex DNA and rpoB RIF resistance mutation panel [Presence]
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicin-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mycobacterium tuberculosis complex rpoB gen mutación de resistencia a rifAMPin:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-CA French (Canada) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
Synonyms: #REF!
fr-FR French (France) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis complex, gene rpoB rifampina resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Complesso di micobatteri della tubercolosi Gene rpoB di complesso di micobatteri della tuberc Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB RIF;甲哌力复霉素 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 受检物 复合体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌复合菌群（复合群、复合菌、复合体、复合物）;结核分支杆菌复合体;结核分支杆菌复合群;结核分支杆菌复合菌群;结核分枝杆菌复合体;结核分枝杆菌复合物;结核分枝杆菌结核菌群;结核杆菌复合菌群 结核分枝杆菌复合菌群（结核分支杆菌复合体、结核分支杆菌复合群、结核分支杆菌复合菌群、结核分枝杆菌复合体、结核分枝杆菌复合物、结核分枝杆菌结核菌群、结核杆菌复合菌群）基因利福平（甲哌力复霉素、利福霉素、立复霉素、立放平）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

48175-4 Mycobacterium tuberculosis katG + inhA gene isoniazid resistance mutation [Presence] by Molecular method

Fully-Specified Name

Component
Mycobacterium tuberculosis katG+inhA genes isoniazid resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
MTB katG+inhA INH h res mut Islt/Spm Ql
Display Name
M. tuberculosis katG + inhA genes isoniazid resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis katG+inhA genes isoniazid resistance mutation

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.21
Last Updated
Version 2.65
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Component to reflect that katG and inhA are native genes in which a mutation causes fluoroquinolone resistance, System from "XXX", and Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: M.tuberculosis-INH-Resistenz PCR /SM
de-DE German (Germany) Mycobacterium tuberculosis katG + inhA-Gene Isoniazid-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Genes de Mycobacterium tuberculosis resistente a isoniazida (katG+inhA):PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mycobacterium tuberculosis genes katG + inhA mutación de resistencia a isoniazida:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-CA French (Canada) Mutation aux gènes de résistance au isoniazide katG + inhA de Mycobacterium tuberculosis:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
fr-FR French (France) Mycobacterium tuberculosis résistance à l'isoniazide katG+inhA mutations gènes:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis, geni katG + inhA isoniazide resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Geni katG + inhA di Mycobacterium tuberculosis iso Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis isoniazide-resistentie (katG + inhA) gen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis.isoniazida resistente:ACnc:Pt:XXX:Ord:Sonda com limite de detecção da amplificação de alvo
Synonyms: ; TB; M TB INHr; Mycobacterium tuberculosum; M tuberculosis; Mtb; Isoniaz; Isoniazide; INH; Nudrazod; Hyzyd; Arbitrary concentration; Point in time; Random; Misc; Miscellaneous; Unspecified; Other; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Acid Fast Bacilli; Mycobact; Myco; AFB; Acid fast bacillus; ANTIBIOTIC SUSCEPTIBILITIES
zh-CN Chinese (China) 结核分枝杆菌 katG+inhA 基因异烟肼耐药突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB C6H7N3O;INH;雷米封 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学 - 基因类 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 受检物 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌异烟肼耐药 (katG + inhA) 基因;M TB INHr;结核分支杆菌.异烟肼耐药型;结核分枝杆菌.异烟肼耐药型;结核分枝杆菌（结核分支杆菌、结核杆菌、结核菌） katG+inhA 基因异烟肼（雷米封）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 阻力

46244-0 Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified by Molecular method

Term Description

Mycobacterium rpoB region gene mutation for Rifampim resistance
Source: Regenstrief LOINC

Part Descriptions

LP267160-2   Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation identified
Property
Prid
Time
Pt
System
Isolate/Specimen
Scale
Nom
Method
Molgen

Additional Names

Short Name
MTB cmplx rpoB RIF mut Islt/Spm
Display Name
M. tuberculosis complex rpoB gene rifAMPin resistance mutation identified Molgen Nom (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation test

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.67
Change Reason
Release 2.67: COMPONENT: Updated Component to reflect that rpoB is a native gene in which a mutation causes rifampin resistance [Approved by LOINC Laboratory Committee in June 2018].; METHOD_TYP: Update Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].; SYSTEM: Updated System from "Isolate" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium tuberculosis-Komplex rpoB-Gen Rifampicin-Resistenz-Mutation identifiziert:Nachweis oder Identität:Zeitpunkt:Isolat oder Probenmaterial:Nominal:Molekulargenetisch
es-ES Spanish (Spain) Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis identificado:Presencia o identidad:Punto temporal:Muestra aislada:Nom:Genética molecular
es-MX Spanish (Mexico) Se identificó una mutación de resistencia a rifAMPina del complejo de Mycobacterium tuberculosis rpoB:Presencia o identidad:Punto temporal:Aislado o espécimen:Nominal:Genética molecular
fr-CA French (Canada) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation, Identifiés:Présence ou identité:Temps ponctuel:Isolat/Échantillon:Nominal:Molgen
Synonyms: #REF!
fr-FR French (France) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation identifiée:Identification:Ponctuel:Isolat/échantillon:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis complex, gene rpoB rifampina resistente, identificato:Prid:Pt:Isolato/Campione:Nom:Molgen
Synonyms: Complesso di micobatteri della tubercolosi Gene rpoB di complesso di micobatteri della tuberc Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie geïdentificeerd:identificator:moment:isolaat of monster:nominaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis DNA.rpoB:Ident:Pt:Isolado:Nom:Sonda com limite de detecção da amplificação de alvo
Synonyms: ; TB; M TB rpoB; Mycobacterium tuberculosum; M tuberculosis; Mtb; Deoxyribonucleic acid; Identity or presence; Point in time; Random; Islt; Isol; Nominal; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Acid Fast Bacilli; Mycobact; Myco; AFB; Acid fast bacillus; ANTIBIOTIC SUSCEPTIBILITIES
zh-CN Chinese (China) 结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变 已鉴定的:存在与否或特征标识:时间点:分离株/标本:名义型:分子遗传学类实验室方法
Synonyms: AFB RIF;甲哌力复霉素 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离出的;分离的;已分离的;检出的;经分离的;经过分离的;经过鉴定的;经鉴定的;鉴定的 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 劳瘵 受检物 复合体 存在;存在与否;特征标识;身份;身份标识 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌复合菌群（复合群、复合菌、复合体、复合物）;结核分支杆菌复合体;结核分支杆菌复合群;结核分支杆菌复合菌群;结核分枝杆菌复合体;结核分枝杆菌复合物;结核分枝杆菌结核菌群;结核杆菌复合菌群 结核分枝杆菌复合菌群（结核分支杆菌复合体、结核分支杆菌复合群、结核分支杆菌复合菌群、结核分枝杆菌复合体、结核分枝杆菌复合物、结核分枝杆菌结核菌群、结核杆菌复合菌群）基因利福平（甲哌力复霉素、利福霉素、立复霉素、立放平）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

46246-5 Mycobacterium tuberculosis katG gene isoniazid high level resistance mutation [Identifier] by Molecular method

Part Descriptions

LP40304-5   Mycobacterium tuberculosis katG gene isoniazid high level resistance mutation
Mycobacterium katG region gene mutation for INH resistance Source: Regenstrief Institute

Fully-Specified Name

Component
Mycobacterium tuberculosis katG gene isoniazid high level resistance mutation
Property
Prid
Time
Pt
System
Isolate/Specimen
Scale
Nom
Method
Molgen

Additional Names

Short Name
M TB katG INH high res mut Islt/Spm
Display Name
M. tuberculosis katG gene INH high level resistance mutation Molgen Nom (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis katG gene isoniazid high level resistance mutation

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.65
Change Reason
Updated Component to reflect that katG is a native gene in which a mutation causes fluoroquinolone resistance, System from "Isolate", and Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium tuberculosis katG-Gen hohe Isoniazid-Resistenz-Mutation:Nachweis oder Identität:Zeitpunkt:Isolat oder Probenmaterial:Nominal:Molekulargenetisch
es-ES Spanish (Spain) Gen katG de alta resistencia a isoniazida de Mycobacterium tuberculosis:Presencia o identidad:Punto temporal:Muestra aislada:Nom:Genética molecular
es-MX Spanish (Mexico) Mutación de resistencia de alto nivel a isoniazida del gen katG de Mycobacterium tuberculosis:Presencia o identidad:Punto temporal:Aislado o espécimen:Nominal:Genética molecular
fr-CA French (Canada) Mutation au gène de forte résistance au isoniazide katG de Mycobacterium tuberculosis:Présence ou identité:Temps ponctuel:Isolat/Échantillon:Nominal:Molgen
fr-FR French (France) Mycobacterium tuberculosis résistance à l'isoniazide à concentration élevée katG mutation gène:Identification:Ponctuel:Isolat/échantillon:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis, gene katG alto livello resistenza isoniazide:Prid:Pt:Isolato/Campione:Nom:Molgen
Synonyms: Gene katG di Mycobacterium tuberculosis con alto l Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis isoniazide hoog niveau resistentie (katG) gen:identificator:moment:isolaat of monster:nominaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis DNA.katG:Ident:Pt:Isolado:Nom:Sonda com limite de detecção da amplificação de alvo
Synonyms: ; TB; M TB katG; Mycobacterium tuberculosum; M tuberculosis; Mtb; Deoxyribonucleic acid; Identity or presence; Point in time; Random; Islt; Isol; Nominal; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Acid Fast Bacilli; Mycobact; Myco; AFB; Acid fast bacillus; ANTIBIOTIC SUSCEPTIBILITIES
zh-CN Chinese (China) 结核分枝杆菌 katG 基因异烟肼高水平耐药突变:存在与否或特征标识:时间点:分离株/标本:名义型:分子遗传学类实验室方法
Synonyms: AFB C6H7N3O;INH;雷米封 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 劳瘵 受检物 存在;存在与否;特征标识;身份;身份标识 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 程度 等级 级 级别 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌异烟肼高水平耐药 (katG) 基因;结核分枝杆菌 DNA.katG;M TB katG;结核杆菌 DNA.katG;结核分枝杆菌（结核分支杆菌、结核杆菌、结核菌） katG 基因异烟肼（雷米封）高水平（高度）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

63072-3 Mycobacterium tuberculosis inhA gene isoniazid low level resistance mutation [Presence] by Molecular method

Fully-Specified Name

Component
Mycobacterium tuberculosis inhA gene isoniazid low level resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
MTB inhA INH low res mut Islt/Spm Ql
Display Name
M. tuberculosis inhA gene INH low level resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis inhA gene isoniazid low level resistance mutation

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.36
Last Updated
Version 2.65
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Component to reflect that inhA is a native gene in which a mutation causes fluoroquinolone resistance, System from "Isolate", and Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium tuberculosis inhA-Gen geringe Isoniazid-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Gen de baja resistencia a isoniacida de Mycobacterium tuberculosis (inhA):PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mycobacterium tuberculosis gen inhA mutación de resistencia de bajo nivel a isoniazida:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-CA French (Canada) Mutation au gène de faible résistance au isoniazide inhA de Mycobacterium tuberculosis:Présence-Seuil:Temps ponctuel:Isolat/Échantillon:Ordinal:Molgen
fr-FR French (France) Mycobacterium tuberculosis résistance à l'isoniazide à faible concentration inhA mutation gène:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis, gene inhA basso livello resistenza isoniazide:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Gene inhA di Mycobacterium tuberculosis con basso Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis isoniazide laag niveau resistentie (inhA) gen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 结核分枝杆菌 katG 基因异烟肼低水平耐药突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB C6H7N3O;INH;雷米封 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 程度 等级 级 级别 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌异烟肼低水平耐药 (katG) 基因;结核分枝杆菌 DNA.katG;M TB katG;结核杆菌 DNA.katG;结核分枝杆菌 katG 基因异烟肼（雷米封）低水平（低度）耐药（抗性）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

89489-9 rifAMPin [Susceptibility] by Genotype method

Fully-Specified Name

Component
rifAMPin
Property
Susc
Time
Pt
System
Isolate
Scale
Ord
Method
Genotyping

Additional Names

Short Name
rifAMPin Islt Genotyp
Display Name
rifAMPin Genotyping [Susc]
Consumer Name Alpha Get Info
Susceptibility to rifAMPin

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.69
Change Reason
Release 2.69: SYSTEM: Updated System to "Isolate" since this concept is about the susceptibility of the viral isolate to the drug, not the susceptibility of the specimen to the drug.;
Order vs. Observation
Both

Example Answer List LL3666-6

Answer Code Score Answer ID
Resistant LA6676-6
Susceptible LA24225-7

Member of these Panels

LOINC Long Common Name
92254-2 Microorganism identification and resistance pattern determination panel by Molecular genetics method
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method
89486-5 Mycobacterial susceptibility panel Qualitative by Genotype method
94053-6 Mycobacterium tuberculosis complex resistance panel by Molecular genetics method

Member of these Groups Get Info

LOINC Group Group Name
LG41103-9 RifampinSusc|Isolate

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Rifampicin:Empfindlichkeit (Mikroorganismen):Zeitpunkt:Isolat:Ordinal:Genotypisierung
es-MX Spanish (Mexico) rifAMPin:Susceptibilidad (microorganismos):Punto temporal:Aislado:Ordinal:Susceptibilidad del genotipo viral
es-ES Spanish (Spain) Rifampicina:Susceptibilidad:Punto temporal:Aislado:Ord:Susceptibilidad al genotipo viral
et-EE Estonian (Estonia) Rifampiin:Susc:Pt:Is:Ord:Genotüpiseerimine
Synonyms: Isolaat Järgarvuline Juhuslik Tundlikkus
fr-CA French (Canada) Rifampicine:Susceptibilité:Temps ponctuel:Isolat:Ordinal:Génotypage
Synonyms: #REF!
fr-BE French (Belgium) Rifampicine:Susceptibilité:Temps ponctuel:Isolat:Ordinal:Génotypage
fr-FR French (France) Rifampicine:Sensibilité:Ponctuel:Isolat:Qualitatif:Génotypage
it-IT Italian (Italy) Rifampicina:Susc:Pt:Isolato:Ord:Genotipizzazione
Synonyms: Punto nel tempo (episodio) Sensibilità (microrganismi) Suscettibilità agli antibiotici Suscettibilità al genotipo virale
nl-NL Dutch (Netherlands) rifampicine:gevoeligheid:moment:isolaat:ordinaal:genotypering
ru-RU Russian (Russian Federation) Рифампин:Чув:ТчкВрм:Изолят:Пор:Генотипирование
Synonyms: Вирусного генотипа чувствительность Порядковый Точка во времени;Момент Чувствительность (микроорганизмов)
tr-TR Turkish (Turkey) Rifampin:Duyr:Zmlı:İzolat:Srl:Genotipleme
zh-CN Chinese (China) 利福平:抗生素敏感性:时间点:分离株:序数型:基因分型
Synonyms: RIF;甲哌力复霉素 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分离物;分离菌;分离菌株;隔离种群 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 抗生素敏感性(微生物);敏感性;某种抗微生物制剂对于某个分离株的影响;药物敏感性;药物敏感性(微生物) 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间

89488-1 Isoniazid [Susceptibility] by Genotype method

Part Descriptions

LP15831-8   Isoniazid
Isoniazid (also called isonicotinyl hydrazine or isonicotinic acid hydrazide) is often abbreviated INH. Isoniazid is a first-line antituberculous medication used in the prevention and treatment of tuberculosis. It is available in tablet, syrup, and injectable forms (given intramuscularly or intravenously), available world-wide, inexpensive to produce and is generally well tolerated. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Isoniazid (Wikipedia)

LP15831-8   Isoniazid
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component
Isoniazid
Property
Susc
Time
Pt
System
Isolate
Scale
Ord
Method
Genotyping

Additional Names

Short Name
Isoniazid Islt Genotyp
Display Name
Isoniazid Genotyping [Susc]
Consumer Name Alpha Get Info
Susceptibility to Isoniazid

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.69
Change Reason
Release 2.69: SYSTEM: Updated System to "Isolate" since this concept is about the susceptibility of the viral isolate to the drug, not the susceptibility of the specimen to the drug.;
Order vs. Observation
Both

Example Answer List LL3666-6

Answer Code Score Answer ID
Resistant LA6676-6
Susceptible LA24225-7

Member of these Panels

LOINC Long Common Name
92254-2 Microorganism identification and resistance pattern determination panel by Molecular genetics method
89876-7 MTB complex rifAMPin and isoniazid resistance panel by Molecular genetics method
89486-5 Mycobacterial susceptibility panel Qualitative by Genotype method
94053-6 Mycobacterium tuberculosis complex resistance panel by Molecular genetics method

Member of these Groups Get Info

LOINC Group Group Name
LG41063-5 IsoniazidSusc|Isolate

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Isoniazid:Empfindlichkeit (Mikroorganismen):Zeitpunkt:Isolat:Ordinal:Genotypisierung
es-ES Spanish (Spain) Isoniazida:Susceptibilidad:Punto temporal:Aislado:Ord:Susceptibilidad al genotipo viral
es-MX Spanish (Mexico) Isoniazida:Susceptibilidad (microorganismos):Punto temporal:Aislado:Ordinal:Susceptibilidad del genotipo viral
et-EE Estonian (Estonia) Isoniasiid:Susc:Pt:Is:Ord:Genotüpiseerimine
Synonyms: Isolaat Järgarvuline Juhuslik Tundlikkus
fr-CA French (Canada) Isoniazide:Susceptibilité:Temps ponctuel:Isolat:Ordinal:Génotypage
fr-BE French (Belgium) Isoniazide:Susceptibilité:Temps ponctuel:Isolat:Ordinal:Génotypage
Synonyms: INH
fr-FR French (France) Isoniazide:Sensibilité:Ponctuel:Isolat:Qualitatif:Génotypage
it-IT Italian (Italy) Isoniazide:Susc:Pt:Isolato:Ord:Genotipizzazione
Synonyms: Punto nel tempo (episodio) Sensibilità (microrganismi) Suscettibilità agli antibiotici Suscettibilità al genotipo virale
nl-NL Dutch (Netherlands) isoniazide:gevoeligheid:moment:isolaat:ordinaal:genotypering
ru-RU Russian (Russian Federation) Изониазид:Чув:ТчкВрм:Изолят:Пор:Генотипирование
Synonyms: Вирусного генотипа чувствительность Порядковый Точка во времени;Момент Чувствительность (микроорганизмов)
tr-TR Turkish (Turkey) İzoniazid:Duyr:Zmlı:İzolat:Srl:Genotipleme
zh-CN Chinese (China) 异烟肼:抗生素敏感性:时间点:分离株:序数型:基因分型
Synonyms: C6H7N3O;INH;雷米封 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分离物;分离菌;分离菌株;隔离种群 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 抗生素敏感性(微生物);敏感性;某种抗微生物制剂对于某个分离株的影响;药物敏感性;药物敏感性(微生物) 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间